Diagnosis of mycobacterial mediastinal lymphadenopathy by transbronchial needle aspiration.
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Biomedical subjects
Publications and source records attributed to C Simecek.
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From 1987 to 1989 22 men and one woman with morphologically certified tumors of the lungs were symptomatically treated with cryocoagulation. The cryoequipment KNF 4/5 with 30 W freezing capacity was used. After treatment in 20 out of 22 patients an objective improvement could be observed. A significant increase of spirographically measured vital capacity was found. Control observations of the results after treatment using a densitographic investigation of the regional distribution of the ventilation included the advantage that valuable informations concerning the effect of the treatment were received without further burden for the patient.
Densitographic examination of the regional pulmonary ventilation is a non-pretentious and non-invasive method which can be used even in very young children, which when aspiration of a non-contrasting foreign body is suspected can confirm by revealing localized bronchial obstruction the presence of a foreign body and determine its localization in the tracheobronchial tree. By repeated records of adequate ventilation at rest in all pulmonary fields it is possible with a minimal radiation load to rule out the suspicion and the child need not be subjected to an endoscopic examination. In five children aged 19 months to 13 years the usefulness of this procedure for the diagnosis of aspiration of a non-contrasting foreign body was proved, as the physical and skiagraphic finding was not convincing, there was discrepancy of anamnestic data and results of repeated skiagraphic examinations, negative auscultation and negative X-ray examination after an anamnestically obvious cse of aspiration, it ws used, for a more accurate localization of the aspired object, and to confirm localized obstruction of pulmonary ventilation in a chronic foreign body of plant origin in the airways. Foreign bodies of plant origin, most frequently aspired by children, are dangerous because they are fragile, swell and exert toxic action on the bronchial mucosa and there is also the danger of rapid development of serious bronchopulmonary complications. Therefore early diagnosis of aspiration is essential in these frequently obscure situations. When the direct skiagraphic signs of their presence in the lower airways are lacking dynamic pulmonary densitography contributes greatly to the diagnosis.
A densitographic evaluation of regional lung ventilation represents a positive contribution also for the diagnosis of x-ray non-contrast foreign bodies aspiration, especially when both physical and skiagraphic findings are unconvincing. Dynamic lung densitography is a convenient undemanding method, that can be used even in the youngest children. In 5 adults and 4 children proven localized bronchial obstruction confirmed the suspicion of aspiration of non-contrast foreign body. In one patient with negative densitographic finding a following bronchoscopy excluded the presence of a foreign body in lower airways, too. Therefore no endoscopy was performed in another adult, as well as in one 19-month old child, who had no densitographic disturbance of regional ventilation. Densitographic examination of regional lung ventilation substantially attributes to early diagnosis of non-contrast foreign body aspiration. Such early diagnosis represents important prevention of the development of serious bronchopulmonary complications. Exclusion of the regional lung obstruction allows to avoid the otherwise indicated bronchoscopy, that does not represent, especially in elderly persons and youngest children, a simple and non risk examination.
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In a group of children aged 4 to 13 years with hypertrophic adenoid vegetation the pulmonary ventilation and mechanics of respiration were examined by global and regional spirography, incl. evaluation of VC, FEV1%, RV, IGV and V-V loops and in six children by whole-body plethysmography. While during global spirography a pathological finding was recorded in 31%, during regional spirographic examination pathological changes of the mentioned functional values were recorded in 86% of the children, which provides evidence that regional spirography combined with the densitographic method can reveal local disorders of pulmonary ventilation which cannot be detected by global spirography. In children under 10 years of age as compared with older children, more marked and more frequent changes of the investigated parameters were observed. Dispensarization of children where a pathological functional funding was present is essential as part of prevention of possible future development of chronic organic lesions of the lower respiratory pathways.
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A disseminated form of pulmonary adiaspiromycosis was estimated in a 48 year old miner. The origin of a hypersensitivity mainly of an immediate allergic type became evident during an immunological examination and was partly indicated also by the tissue reaction and by elevated level of serum IgE (480 I.U.). Of great interest was the finding of a coagulation necrosis in the bioptic material. An examination of functions disclosed signs of a moderate obstruction which was latent when first observed with normal value of lung diffusion capacity. Its activation during stress was indicated by an increase in the value both of the residual volume and the IGV to the upper border of their limits. No apparent changes occurred in the disease during our two-year-investigation. Neither the total state of the patient nor the x-ray picture reflected the effect of a prolonged treatment with antituberculotics.
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