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Biomedical subjects

C Simonetti

Publications and source records attributed to C Simonetti.

At least 37 records · Page 2Linked to original sources
PubMed1977

[Particular aspects of cardiomyopathy in Landouzy-Déjérine's progressive muscular dystrophy. Study of a family (author's transl)].

In the study of a family affected by progressive muscular dystrophy (DMP) of facio-scapulo-humeral type (f.s.o.) the myocardial involvement has been found to be constant and of moderate degree. The myocardial component has been found to appear in the adult age with initial and prevalent atrial involvement. In one case the myocardiopathy was not associated with appreciable clinical signs of skeletric myopathy. Possible causes of the pecuationship between the DPM type f.s.o. associated myocardiopathies and familial idiopathic cardiomyopathies are outlined.

Adult↗
PubMed1976

Physical, chemical and immunological studies on bovine factor VIII.

Highly purified bovine factor VII prepared according to our technique and having a specific activity of 500 U/mg protein has been studied. The chemical analysis of the preparation revealed it to be composed of amino acids, lipids (8-10%) and carbohydrates (7%). The lipid moiety can be removed by chromatography. Different mechanism of inactivation of bovine factor VII and the possible molecular changes induced by the inactivating agents were studied. EDTA and EGTA provoke a weakening of the bonds linking the structural elements of the molecule, which allows for the separation of two different components of the molecule by gel filtration. Upon treatment with thrombin, the carbohydrate content of bovine factor VIII decreases without any apparent degradation of the protein moiety of the molecule. The fact that precipitating and neutralizing antisera against factor VIII were obtained, shows that the molecules modified by EDTA and thrombin still have the antigenic properties of factor VIII. The inhibitor developed by hemophiliacs transfused with human factor VIII is bound to bovine factor VIII, forming a complex reveal that it is composed of bovine factor VIII and human gamma-globulin. Bovine factor VIII in the complex retains some antigenic determinants which bind rabbit antiserum against bovine factor VIII, as shown by neutralization of the antiserum and by precipitation studies.

Animals↗
PubMedDate not supplied

Popliteal artery entrapment: MR findings.

A 35-year-old woman with a history of claudication was examined by means of echodoppler, angiography, and MR imaging using gradient rephased sequences, performed at rest and during stress. Magnetic resonance imaging allowed the evaluation of the relationships between the gastrocnemius muscle and the popliteal artery at rest and the evidence of the occlusion during stress. This combined morphological and functional evaluation makes MR a procedure of choice for assessment of young adults with intermittent claudication.

Adult↗
PubMedDate not supplied

Pattern of anesthetic diffusion during peribulbar infiltration: a CT evaluation.

PURPOSE: The aim of this study was to evaluate the changes undergone by orbital structures during peribulbar anesthesia. METHODS: CT-thin slices were acquired and 8-9 ml of anesthetic, with a small part of low-density non-ionic water-soluble contrast medium were injected under CT guide once to follow extraconal spreading and diffusion to intraconal structures and above all, the surgically important structures such as recti muscles, orbicular and optic nerve sheath. Conjunctival sack involvement was assessed and conjunctival chemosis was rated. Induced ptosis was evaluated, verifying change before and after eyepressure. RESULTS: The results help in optimizing anesthetic technique, above all concerning the site, materials and quantity, and suggest the amount of anesthesia could be reduced. CONCLUSIONS: The peribulbar anesthetic technique proved effective and safe for patients.

Aged↗
PubMedDate not supplied

[Sleep disturbances in a case of Morvan's chorea (author's transl)].

Six nocturnal polygraphic recordings were carried out in a young man with fibrillary chorea of Morvan, during the acute period of the disease. Sleep was remarkably fragmented by numerous and brief awakenings but the total sleep time fluctuated between 157 and 312 mins.; the sleep structure was altered by the almost total absence of stages 3,4 and REM. During the day, the subject had one or two periods of sleep (1-2 hours) and complained of being tired. The nocturnal awakenings were correlated by the patient with pain and burning dysaesthesiae of distal distribution that were more severe than those occurring during the day. The patient improved gradually, and five month later both sleep disturbances and other signs of disease had disappeared.

Adult↗
PubMedDate not supplied

[Analysis of risk of biological accidents at a urban health area].

The makers have examined 455 fingerprint cards of accidents at biologic risk needed in a sanitary structure from the month of november 1995 to the month of december 1998. After they have described the protocol of the sanitary supervision applied, the procedure of the accidents, the qualifications, and the departments mainly interested by the subject of study event, they have pointed out the need of a greater vaccinable covering against the virus B, parvying attention to the "non responders" subjects, thinking also it's necessary bigger resources for the personnel, training and information.

Catchment Area, Health↗
PubMedDate not supplied

[Subarachnoid hemorrhage as initial manifestation of polyarteritis nodosa].

The polyarteritis nodosa (P.A.N.) is frequently responsible of neurological disorders, both central and peripheral. However an involvement of the Central Nervous System is unusual at the beginning of the disease. Such particular case is reported having occurred in a man aged 49, struck by a subarachnoidal hemorrhage, which was an initial symptom of P.A.N. The differential diagnosis is not always easy in such cases, since the clinical findings could be mistaken for those of a subarachnoidal hemorrhage due to a malformed vessel rupture.

Humans↗