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C Smyth

Publications and source records attributed to C Smyth.

42 records · Page 3Linked to original sources
PubMed1984

Mitogenicity of Naegleria fowleri extract for murine T lymphocytes.

The whole-killed pathogenic free-living amoeba, Naegleria fowleri, contained mitogenic activity (NFM) for mouse spleen cells. Similar preparations from the non-pathogenic amoeba N. gruberi and the pathogenic Acanthamoeba culbertsoni lacked mitogenic activity. Fluids from N. fowleri cultures, containing amoeba antigens, also failed to cause proliferation of mouse spleen lymphocytes. Spleen cells from athymic nude mice failed to respond to NFM. In addition, nylon wool non-adherent, but not the adherent, spleen cell subpopulation proliferated in the presence of NFM. These results show that the factor(s) is mitogenic for T lymphocytes. The spleen cells from mice treated with cyclophosphamide doses known to deplete T suppressor cell activity from this organ failed to respond to NFM, indicating that NFM may be mitogenic for T suppressor cells.

Amoeba↗
PubMedDate not supplied

A case study of an abused older woman.

Because little is known about elder abuse, it is difficult to propose strategies for primary prevention or to select the most efficacious strategies to deal with abuse. Intervening is also complicated by personal and professional values that often have their origin in one's own family. Elder abuse is a complex challenge to health professionals, making assessment, diagnosis, treatment, and evaluation difficult. Using a case study approach, we illustrate these complexities, describe the dynamics, and apply a decision-making model to the management of a case of abuse. Theoretical research and background information are woven into the discussion of the case to explain further the dynamics.

Aged↗
PubMedDate not supplied

Linkage analysis of manic depression (bipolar affective disorder) in Icelandic and British kindreds using markers on the short arm of chromosome 18.

Attempts were made to follow up results of a previous linkage study which suggested that a locus-modifying susceptibility to bipolar and related unipolar affective disorder might be present in the pericentromeric region of the short arm of chromosome 18. Twenty-three multiply affected pedigrees collected from Iceland and the UK were genotyped using three highly polymorphic microsatellite markers at D18S37, D18S40 and D18S44 which span the region implicated. Lod score analyses under the assumption of heterogeneity and non-parametric linkage analyses were performed. The total lod scores obtained were strongly negative, and analysis allowing for heterogeneity did not suggest that any subgroup of the families was linked. Model-free linkage analysis using extended relative pair analysis and MFLINK also failed to detect any evidence for linkage. Our study provides no support for the presence of a locus-modifying genetic susceptibility to bipolar affective disorder in the pericentromeric region of chromosome 18q11. Further analyses in independent samples should help to reveal whether our negative results are due to locus heterogeneity or whether the original results were false-positive.

Alleles↗