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C Soderland

Publications and source records attributed to C Soderland.

5 recordsLinked to original sources
PubMed1977

HLA variants of cultured human lymphoid cells: evidence for mutational origin and estimation of mutation rate.

Variants of a diploid lymphoid cell line that show a loss of HLA-B27 antigen occur randomly in time and independently of exposure to the alloantiserum used for their isolation. From these and previous findings of variant stability, inducibility by mutagens, and the absence of linked variation, we colclude that most HLA variants arise by mutation. The mutation rate for HLA-B27 loss is 8 x 10(-7) per cell per generation.

B-Lymphocytes↗
PubMed1976

Isolation of stable and unstable ("suppressed") Beta2-microglobulin-deficient clones from a lymphoid cell line.

After selection with anti-Beta2m and C against a human lymphoid line, about 10% of surviving clones manifested decreased cytotoxic sensitivity to anti-Beta2m("suppression") which gradually reverted to normal after 35 to 55 cell doublings. Antiserum alone induced suppression. Exposure of suppressed clones to DMSO substantially reversed suppression. One clone, surviving selection, had a stable decrease in anti-Beta2m sensitivity; it possibly represents a Beta2m mutation.

Beta-Globulins↗