Biomedical subjects

C Souchay

Publications and source records attributed to C Souchay.

3 recordsLinked to original sources

PubMed2005

Regulation of expression of galectin-7 in human nasal polyps by budesonide.

BACKGROUND: Nasal polyposis is a model for the study of inflammatory processes. We analyzed the expression of galectin-7, a growth regulator, in surface epithelium, glandular epithelium, and connective tissue in human nasal polyps, and examined the effect of the glucocorticoid budesonide on its expression in human nasal polyps ex vivo. METHODS: Using quantitative, computer-assisted microscopy and immunohistochemistry, we measured galectin-7 expression in nine nasal polyps obtained by surgical resection. Five polyps came from allergic patients and four came from non-allergic patients. RESULTS: Galectin-7 was expressed in all three polyp tissues analyzed. Treatment of polyps from allergic and non-allergic patients with 50 ng/ml budesonide increased the extent of galectin-7 expression in the connective tissue (p = 0.01). Conversely, budesonide at this concentration did not apparently affect galectin-7 expression in glandular epithelium; only a slight decrease in the percentage of the galectin-7-immunopositive cells was observed. In the surface epithelium of nasal polyps from non-allergic patients, the percentage of galectin-7-immunopositive cells was decreased (p = 0.03) by treatment with 250 ng/ml budesonide. In nasal polyps from allergic patients, this percentage was increased by treatment with 50 ng/ml budesonide (p = 0.0001). CONCLUSIONS: These data are consistent with a role for galectin-7 in the regulation of cell growth through a pro-apoptotic effect. Galectin-7 expression coincides with the degree of epithelial stratification, and is subject to upregulation in the connective tissue in response to treatment with 50 ng/ml budesonide. Budesonide modulates galectin-7 expression differently in the surface epithelia of polyps from allergic and non-allergic patients.

Anti-Inflammatory Agents↗

PubMed2002

[Metamemory and Parkinson's disease].

Metamemory is a multifaceted concept, which deals with the individual's knowledge and control of his or her own memory system. One metacognitive ability that has considerable importance in everyday life is the ability to control his or her own memory. In this study, we have examined whether Parkinson's disease affects the degree to which a person allocate study time. 17 Parkinson subjects and 18 older controls participated in this study. Parkinson subjects and control subjects made a readiness recall task in which subjects monitor themselves the learning procedure, allowing to measure metamemory control (study time by item). Control subjects were found to take more time in study than parkinson subjects. The lists were learned under two condition: a self-paced condition in which subjects could study each word as long as they would and an experimenter-paced condition. The analysis revealed that control subjects recalled more items than parkinson subjects only in the self-paced condition. These results suggested that Parkinson-related differences in the allocation of study time mediate a part of Parkinson-related differences in memory performance.

Aged↗

PubMed2000

Aging, episodic memory feeling-of-knowing, and frontal functioning.

Groups of normal old and young adults made episodic memory feeling-of-knowing (FOK) judgments and took 2 types of episodic memory tests (cued recall and recognition). Neuropsychological tests of executive and memory functions thought to respectively involve the frontal and medial temporal structures were also administered. Age differences were observed on the episodic memory measures and on all neuropsychological tests. Compared with young adults, older adults performed at chance level on FOK accuracy judgments. Partial correlations indicated that a composite measure of frontal functioning and FOK accuracy were closely related. Hierarchical regression analyses showed that the composite frontal functioning score accounted for a large proportion of the age-related variance in FOK accuracy. This finding supports the idea that the age-related decline in episodic memory FOK accuracy is mainly the result of executive or frontal limitations associated with aging.

Adult↗