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Biomedical subjects

C Spinelli

Publications and source records attributed to C Spinelli.

At least 55 records · Page 3Linked to original sources
PubMed1989

A conjugate of prednisolone with albumin is pharmacologically active in macrophages.

In order to selectively deliver prednisolone to macrophages, this drug was coupled to human albumin. In experiments in vitro the conjugate entered into macrophages in much higher amounts than in fibroblasts; in the former cells it was pharmacologically active as demonstrated by the inhibition of prostaglandin E2 and thromboxane A2 production. Prednisolone-albumin conjugate might be useful in research on steroids; moreover in some pathological conditions it might produce the therapeutic effects of these drugs without causing their side effects.

Albumins↗
PubMed1988

The efficacy of PACE in the remediation of naming deficits.

This study compared the effects of PACE and traditional stimulation therapy in the remediation of naming deficits. The subject was a 66-year-old conduction aphasic. An ABCBC time-series design was employed. Greater gains were evidenced during the PACE phases of treatment on two types of probes--confrontation naming and picture description tasks.

Aged↗
PubMed1988

Correlation between 5-year survival of T1-T2N0 breast cancer and some pathological parameters.

In order to more clearly define the factors influencing prognosis, 113 cases of T1-T2N0 breast cancers, all operated on by means of radical mastectomy, were reviewed. The following pathologic parameters were analyzed in relation to 5 years survival: histological type, nuclear grading, vascular embolization, size and border of the tumour, and sinus histiocytosis, diffuse cortical hyperplasia and germinal center hyperplasia of axillary nodes. We observed a close correlation between the presence of sinus histiocytosis and prognosis, as many authors have reported. Diffuse cortical hyperplasia stands out from our data as the most unfavourable prognostic factor.

Adult↗
PubMed1987

[Bladder instability in patients with prostatic hypertrophy. Urodynamic study].

A urodynamic study was conducted in 37 patients with benign prostatic hypertrophy before and five months after transvesical prostatic adenomectomy. Prior to the operation, 17 patients had cystometric signs of unstable bladder which persisted after the operation in only two patients. Normal detrusor function was restored in the other 15 patients. The pathophysiological and clinical aspects of bladder neck obstruction in patients with prostatic hypertrophy are discussed.

Aged↗
PubMed1985

Leiomyosarcoma of the prostate in adults.

Three cases of prostatic leiomyosarcoma and a brief review of the literature are presented. The authors emphasize the differences in clinical features, management and prognosis between the sarcomas occurring in childhood and the rarest leiomyosarcoma of elderly patients.

Aged↗