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Biomedical subjects

C Staiger

Publications and source records attributed to C Staiger.

41 records · Page 3Linked to original sources
PubMed1980

A rapid and sensitive method for the determination of phenazone (antipyrine) using gas-liquid-chromatography with nitrogen detection.

A simple and rapid method for the quantitative determination of antipyrine, using gas-liquid-chromatography with nitrogen detection, is described. Only one extraction step is needed, the recovery is 91.2% and the precision varies between 3.14--1.96%. The lower limit of quantitative assay reached 0.1 mg/l plasma. During routine handling the method was easy, quick and cheap.

Antipyrine↗
PubMed1980

[Influence of ranitidine on antipyrine metabolism (author's transl)].

Antipyrine kinetics were determined in 6 healthy volunteers before and after the end of a 1 week treatment period of ranitidine 150 mg twice a day. The mean antipyrine half-life (h) was before 12.6 +/- 4.6 h and after ranitidine treatment 12.0 +/- 2.6 h. Antipyrine clearance (ml/min) and volume of distribution (1) were not altered following ranitidine administration. The results suggest that ranitidine has no influence on antipyrine-metabolism in healthy volunteers.

Adult↗
PubMed1980

Biphasic initial phase of platelet aggregation inhibition after oral aspirin.

For one hour after the ingestion of 1 g aspirin the pharmacodynamics of acetylsalicylic acid with regard to the inhibition of platelet aggregation were studied in nine healthy male volunteers. Plasma salicylic acid (SA) and acetylsalicylic acid (ASA) levels were measured, and platelet aggregation was controlled by the collagen-induced aggregation. It took 12 - 24 minutes till the maximum of platelet aggregation inhibition was reached; maximal inhibition was only observed with ASA levels above 4.5 /microgram/ml and total ASA levels above 10 /microgram/ml. At that time already more than 50% of the total ASA were hydrolysed to minimally active SA. In spite of further increasing ASA levels inhibition of platelet aggregation decreased again. The different sensitivity of platelet- and vessel wall cyclooxygenase to aspirin does not explain our findings.

Administration, Oral↗