PubMed Health⌕ Search

Biomedical subjects

C Stock

Publications and source records attributed to C Stock.

36 records · Page 2Linked to original sources
PubMed1976

[Double-blind study for the prevention of postoperative thrombosis].

In a double-blind study a randomized group of 96 patients with abdominal operations received a placebo, dipyridamol/acetylsalicylic acid or ASA alone. Thrombi were verified by the 125-I-fibrinogen test. In 38% of the placebo group deep venous thrombosis (DVT) was found, while only 10% of the dipyridamol/ASA group (P less than 0,05) and 28% of the ASA treated patients (not significant) showed radioactive thrombi. DVT were localized in 83.8% in the calf region. 48.6% of increasend activities were registered up to the end of the first postoperative day, 78.3% up to the third day. The results emphasize the importance of a general antithrombotic prophylaxis. Dipyridamol/ASA seems to be efficient in this regard for abdominal procedures.

Abdomen↗
PubMed1975

Microfilamentous system and secretion of enzyme in the exocrine pancreas. Effect of cytochalasin B.

The microfilaments in the acinar cell of the exocrine pancreas are essentially located in the apical part of the cell: thin microfilaments (50 A), cytochalasin B (CB)-sensitive, form the axis of the microvilli and a network lying beneath the apical membrane; thicker filaments (100 A), at least partly CB-insensitive, form bundles parallel to the plasma cell membrane and the desmosomal links. CB interaction with the acinar cell of the exocrine pancreas involves at least two sites: a membrane site involved in the inhibitory effect of CB on the monosaccharide transport and a less sensitive site at the filamentous level at least partly responsible for the inhibitory effect of CB in the secretion of the exportable enzyme from the pancreatic cell. CB did not alter the energy balance of the acinar cell nor the exchanges of 15-Ca between the extracellular medium and the pancreatic tissue. CB (2 times 10-minus 7 and 2 times 10-minus 6 M) has secretagogue properties whereas CB (2 times 10-minus 5 M) has inhibitory effect on stimulated secretion and secretagogue properties. The mechanism of these secretory effects is not yet explained. The analysis presented in this investigation affords strong evidence for the involvement of the microfilamentous network in the last steps of the secretory cycle in the acinar cell of the exocrine pancreas.

Adenosine Triphosphate↗
PubMed1975

[Renal preservation: comparative effectiveness of 2 simple perfusion technics].

The authors compare the efficacy of two perfusates, Collins' solution and Perfudex, for conservation of kidneys for short periods by perfusion and hypothermic immersion. 22 dog kidneys, removed by lombotomy, were preserved for 24 hours with one or other of these solutions and then re-implanted into their host. Radio-isotopic renography, the uptake of Hg 197 Cl3 and a hippuran renogram, used to assess the function of the transplants, suggested the functional superiority of kidneys preserved with Collins solutions. Histological controls carried out beyond the 10 th post-operative week, confirmed these results. The correlations observed between these various findings also assessed the reliability of radio-isotope examinations in the exploration of renal function.

Animals↗
PubMed1975

[Existence of cytoplasmic inclusions in acinic cells of the exocrine pancreas of the hyperglycemic obese mouse].

Peculiar cytoplasmic inclusions with crystalline pattern are described in the obese hyperglycaemic mouse pancreas acinar cells. They are generally associated with filamentous structures. However, crystalline and filamentous inclusions have also been observed in isolated forms. These inclusions are not digested by pronase. Since they have also been encountered in normal mice, it seems that the hyperglycaemic syndrome does not play a role in inducing their formation.

Acid Phosphatase↗
PubMedDate not supplied

T-lymphocyte subpopulations in rheumatoid arthritis. II. Definition by monoclonal antibodies.

Samples of peripheral blood of 27 patients with seropositive rheumatoid arthritis (RA) and 27 healthy age- and sex-matched controls were coded and studied for lymphocyte subpopulations. Monoclonal antibodies and indirect immunofluorescence were used to analyse subpopulations of purified T cells: OKT3 reacts selectively with all peripheral human T cells, OKT4 defines the helper/inducer subpopulation and OKT8 the suppressor/cytotoxic T cells. RA patients had a significantly lower relative lymphocyte count (p less than 0.001). whereas the percentage of all T cells was similar in patients and controls, RA patients had a significantly higher proportion of helper/inducer cells (62 +/- 1.3 vs. 56 +/- 1.0, p less than 0.005) and significantly decreased suppressors/cytotoxic cells (25 +/- 1.5 vs. 32 +/- 1.0; p less than 0.001). This resulted in an increased "immunoregulatory ratio" of helper to suppressor cells in RA patients (2.68 +/- 0.17) compared to their normal controls (1.83 +/- 0.10; p less than 0.001). The proportions of T cells expressing HLA-D-like antigens (defined by a monoclonal antibody to human Ia) was not different in patients and controls. These findings confirm conclusions derived from our previous study of T cell subsets defined by the expression of Fe-receptors (Tm and Tg), that in the peripheral blood of patients with RA, helper mechanisms predominate over suppressor mechanisms. This derangement of the immunoregulatory balance may have an important role in the pathogenesis of seropositive RA.

Adult↗