Biomedical subjects

C Stoupis

Publications and source records attributed to C Stoupis.

26 records · Page 2Linked to original sources

PubMed1991

Clinical, radiologic and magnetic resonance monitoring for skeletal toxicity in pediatric patients with cystic fibrosis receiving a three-month course of ciprofloxacin.

Because of arthropathic toxicity observed in growing animals the quinolone antibiotics are not recommended for use in children. Recently, magnetic resonance imaging performed in juvenile animals was found to predict ciprofloxacin-induced cartilage damage at the knee joint. We conducted clinical, laboratory, radiologic and magnetic resonance imaging investigations in 13 prepubertal (age range, 6 to 13 years) and 5 postpubertal patients (age range, 14 to 24 years) with cystic fibrosis at the start and the end of a 3-month course of ciprofloxacin (30 mg/kg of body weight/day, administered orally in two equal doses) and at follow-up 4 to 6 months later. Our comprehensive monitoring gave no evidence for arthropathogenicity. Detailed physical skeletal function tests, height velocity values, laboratory studies of bone metabolism and conventional radiographs of both knees revealed no abnormalities. Moreover the serial magnetic resonance images of the left knee demonstrated lack of joint effusion, intact two-layer appearance of the cartilage and unaffected thickness of the articular cartilage measured at five anatomically different points. Our results together with the published data on quinolone use in pediatrics suggest that ciprofloxacin does not cause arthropathy in humans.

Adolescent↗

PubMedDate not supplied

Hemorrhagic lymphangioma mimicking hemoperitoneum: MR imaging diagnosis.

Omental cystic lymphangioma is an uncommon malformation that occurs in children. The authors report the magnetic resonance (MR) imaging findings in a case of hemorrhagic cystic abdominal lymphangioma, which clinically mimicked a recurrent hemoperitoneum. They demonstrate the superiority of MR imaging relative to computed tomography and ultrasound in diagnosing large hemorrhagic cystic masses and differentiating them from free intraperitoneal fluid with multiplanar imaging and fluid characterization. This enables precise tumor localization and extension, aiding surgical resection.

Child, Preschool↗

PubMedDate not supplied

Recurrent biliary cystadenoma: MR imaging appearance.

The authors report the case of a 37-year-old woman with a biliary cystadenoma that mimicked a liver cyst. The magnetic resonance (MR) imaging features of this rare lesion were correlated with the pathologic findings, showing the potential of MR imaging for depicting and aiding in the diagnosis of biliary cystadenoma and its recurrence.

Adenoma, Bile Duct↗

PubMedDate not supplied

Castleman disease mimicking an aggressive retroperitoneal neoplasm.

A case of Castleman disease of the retroperitoneum in a 26-year-old woman is presented. Sonography, computed tomography, and magnetic resonance imaging demonstrated a large retroperitoneal mass with somewhat heterogeneous imaging characteristics. Although a definitive preoperative diagnosis was not possible, magnetic resonance imaging was useful in delineating the extent of the tumor and defining the characteristics of surrounding soft tissues.

Adult↗

PubMedDate not supplied

Dose optimization of nonionic contrast agent in dynamic computed tomography scanning of the abdomen and pelvis.

A prospective, randomized study was performed to examine the image quality of varying reduced doses of an intravenous (IV) nonionic contrast agent (ioversol, 320 mg/ml organically bound iodine) compared with the quality obtained using the maximum permissible dose (150 ml) of the same agent. Forty-five patients referred for abdominal-pelvic computed tomography (CT) scan were randomized into five groups to receive contrast doses equivalent to 100, 75, 65, 50, or 30% of 150 ml of contrast agent. The images were scored for diagnostic image quality in eight anatomical regions of interest and, in addition, quantitative analysis of density measurements were performed in the abdominal aorta and inferior vena cava. There was no statistically significant difference in either image quality, in any anatomical region, or in vascular density measurements between the group receiving 100% and the group receiving 75% of 150 ml of nonionic contrast agent. Patients receiving 65% and lower doses demonstrated a statistically significant decrease in enhancement, although all scans were diagnostically adequate. This study demonstrates that dynamic abdominal and pelvic CT scans obtained using a reduced dose of nonionic IV contrast agent are equivalent in diagnostic image quality compared with those scans obtained with the higher permissible dose of the same agent.

Adult↗

PubMedDate not supplied

CT of abdominal barium intravasation.

We report a case of barium intravasation due to misplacement of the catheter tip during a barium enema examination, leading to vaginal laceration and barium sequestration within the reticuloendothelial system of a 57-year-old woman who survived this potentially fatal event. The radiologic appearance on CT, sonography, MR, and plain radiography is presented. Computed tomography demonstrated barium sequestered by the liver, spleen, and renal cortex. The portal veins were seen as branching radiolucent densities superimposed on a dense parenchymal background.

Barium Sulfate↗

PubMedDate not supplied

Improved technique for pancreatic MRI: value of oblique fat suppression imaging with oral barium administration.

PURPOSE: Our goal was to determine the efficacy of a dedicated protocol for pancreatic MRI using fat suppression, oblique plane orientation, and barium as an oral contrast agent. METHOD: Fifty-two patients were enrolled in our study. In each patient, the stomach and duodenum were opacified with 300 ml oral barium. In all patients conventional SE T1- and T2-weighted images and fat-suppressed axial and oblique T1-weighted images of the upper abdomen and the pancreas, respectively, were obtained. The different T1-weighted sequences were compared for visualization of the pancreas and for lesion conspicuity. Oblique images were obtained in a plane parallel to the overall axis of the pancreas. All sequences were qualitatively assessed by two independent blinded readers and statistically compared. RESULTS: The combination of fat suppression and oblique imaging significantly improved the visualization of the different anatomic portions of the normal pancreas as well as pathologic findings in the pancreas in 70-92% of the cases compared with conventional axial T1-weighted imaging (p < 0.001) and in 52-75% of the cases compared with axial fat-suppressed T1-weighted imaging (p < 0.001), respectively. Increased image noise and blurring artifacts resulted in slight image degradation after Gd-DTPA administration. Barium as a duodenal contrast agent was beneficial for delineation of the pancreatic head from the adjacent bowel structures. CONCLUSION: In pancreatic imaging, fat-suppressed T1-weighted imaging is superior to conventional T1-weighted imaging, and oblique imaging is superior to axial imaging. Intravenous Gd-DTPA administration was useful only in selected cases.

Adipose Tissue↗

PubMedDate not supplied

The Rocky liver: radiologic-pathologic correlation of calcified hepatic masses.

Although relatively uncommon in daily clinical practice, calcification may be found in inflammatory hepatic lesions and in benign and malignant liver neoplasms. The most common source of calcified hepatic lesions is inflammatory conditions such as granulomatous diseases (e.g., tuberculosis). The calcification typically involves the entire lesion and appears as a dense mass that can produce artifacts on computed tomographic (CT) scans. Echinococcus cysts have curvilinear or ring calcification. Hemangiomas, especially large ones, may contain large, coarse calcifications that are centrally located in areas of fibrosis; these may be seen at CT (20% of cases) or radiography (10%). In hepatocellular adenoma, calcifications may be solitary or multiple and are usually located eccentrically within a complex heterogeneous mass. Calcifications in fibrolamellar carcinoma have been reported in 15%-25% of cases at CT and occur in a wide variety of patterns. Calcifications in intrahepatic cholangiocarcinoma are typically accompanied by a desmoplastic reaction and are visible at CT in about 18% of cases. Calcified hepatic metastases are most frequently associated with mucin-producing neoplasms such as colon carcinoma. Knowledge of the pathologic features of each entity helps radiologists to better recognize the shape, size, density, number, location, and distribution of hepatic calcifications seen on images and to narrow the differential diagnosis.

Calcinosis↗