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Biomedical subjects

C Strozzi

Publications and source records attributed to C Strozzi.

At least 55 records · Page 3Linked to original sources
PubMed1979

Therapeutic effects of pindolol and nifedipine in patients with stable angina pectoris and asymptomatic resting ischemia.

A single blind randomized parallel study designed to assess the anti-anginal efficacy of pindolol and nifedipine was carried out in 42 ambulatory coronary patients with stable angina pectoris. Drug efficacy was assessed in terms of (a) pain, (b) frequency of anginal episodes, (c) nitroglycerin consumption, (d) exercise tolerance and (e) ST-segment changes. The effect of these drugs on asymptomatic resting myocardial ischemia was also assessed by means of 24-h dynamic electrocardiography (DCG). All patients were checked at weekly intervals. At the end of a 4-wk placebo period, the patients were randomly assigned either to the pindolol or nifedipine group. The treatment lasted for 45 days. During the placebo period, ischemic ECG changes and symptoms of coronary insufficiency were detected in all patients. Furthermore, 12 out of 42 patients had asymptomatic myocardial ischemia at rest. One patient from each group was dropped because of tolerance. At the end of the 45-day study, pindolol and nifedipine were equi-effective on spontaneous and effort-related angina. There were, however, some differences: increased tolerance to exercise appeared earlier with pindolol: the pindolol group showed a slightly reduced while the nifedipine group showed a slightly increased heart rate. Furthermore, nifedipine reduced or eliminated asymptomatic myocardial ischemia in 6 out of 7 patients while only 1 out of 5 improved in the pindolol group.

Adult↗
PubMed1979

[Changes in precordial movements in non-ischaemic heart disease patients after i.v. administration of isoproterenol and dopamine. Comparison between normal and cardiopathic subjects (author's transl)].

18 patients with non-ischemic heart disease have been studied with reference to the kinetocardiographic changes before and after i.v. administration of dopamine (DOP) (Revivan) or Isoproterenol (ISP) (Aleudrin). For this purpose a simultaneous registration of ECG (lead D2), Kinetocardiogram (KCG) in K25 and K45 was performed. Volume curves were considered as a normal features of KCG, curves showing systolic outward movements during the ejection phase were classified as pathologic. The reduction or disappearance of the systolic movements during the drug administration, were considered as kinetic improvement, the increase of their site was judged as kinetic worsening. During the infusion, 17 KCGs maintained a normal morphological pattern; out of 19 pathological KCGs, 4 did not show any change, and 15, 5 reached a complete normalization. It is pointed out the overlap of the precordial kinetics in the ventricular hypertrophies and in the normal subjects (kinetic improvement), and the possibility to differentiate a systolic outward movement due to synergic contraction of hypertrophied ventricle from a systolic outward movement to be reffered to a diskynetic contraction in the myocardial ischemia (kinetic worsening).

Adolescent↗
PubMed1979

The therapeutic value of clonidine in patients with coronary heart disease.

11 coronary patients, 8 with mild hypertension, were treated with clonidine, at a dose of 75 micrograms b.i.d. per os for a week. The effect of the drug on coronary heart disease was assessed by means of a symptom-limited multistage exercise test on the cycloergometer. Clonidine was effective in reducing the exercise-induced increases in blood pressure (by 15.5 +/- 6.1%), the double product (by 34.8 +/- 20.8%) and the electrocardiographic ischemic changes. In 2/4 patients, effort related ventricular extrasystoles were reduced by greater than 50% after clonidine. The drug worsened the anginal pain in 3 and relieved the pain in 3 patients. However, it reduced the exercise-induced ST-T segment downsloping in 7 patients. The tolerance was good, since only 3/11 patients reported slight dry mouth, sedation and pyrosis. In view of the electrocardiographic effect, further studies with clonidine on myocardial ischemia should be performed.

Angina Pectoris↗
PubMed1978

Initial clinical experience of lorcainide (Ro 13-1042), a new antiarrhythmic agent.

Lorcainide is a promising antiarrhythmic agent that belongs to the class of local anesthetics. It was tested in 7 patients with malignant ventricular arrhythmias that were resistant to other antiarrhythmic agents. Lorcainide was effective in all cases (complete disappearance of arrhythmias in 6 cases and more than 50% disappearance in the 7th case), and the tolerance was within acceptable limits. The drug was effective at rest, as assessed by 24-h dynamic electrocardiographic monitoring, and during physical exercise. Longer studies with more patients are warranted, since the drug appears to be a promising antiarrhythmic agent.

Acetanilides↗
PubMed1978

[Hemodynamic and electrocardiographic effects caused by intravenous infusion of a tricyclic antidepressive agent dibenzepin].

The cardiovascular (blood pressure, heart rate, central venous pressure) and ECG changes caused by dibenzepine-infusion (720 mg/day for 48 hours) have been assessed. Mean blood pressure and heart rate did not show significant changes. In some patients, however, distinct changes in both variables were observed. Central venous pressure was not affected. The infusion elicited changes in the repolarisation phase of the ECG: it did not, however, alter either the automaticity or the conductivity of the heart. These results were obtained in 40 depressive patients, whose general conditions and cardiovascular state were excellent and must not be extrapolated for cardiopathic patients. The risks inherent in this therapeutic approach are discussed.

Adolescent↗
PubMed1977

The kinetocardiogram during the isoproterenol test for the assessment of coronary heart disease.

50 patients, 20 without heart disease and 30 with coronary heart disease (CHD), were studied by kinetocardiography (KCG), before and after administration of isoproterenol (initial dose 2 microgram/min, maximum dose 6 microgram/min). In the control subjects the KCG was unaffected by the drug. In contrast, in most of the patients with CHD isoproterenol induced the appearance or the increase of paradoxical systolic bulges, which are regarded as the expression of ventricular dyskinesia resulting from isoproterenol-induced transient regional ischemia. This test is recommended as a valuable noninvasive method for the diagnosis of ischemic ventricular dyskinesia.

Adolescent↗
PubMed1977

[Kinetocardiographic surveys in coronary heart disease patients during infusion of isoproterenol and dopamine. A contribution to the diagnosis of coronary insufficiency (author's transl)].

80 patients affected by coronary heart disease, with or without infarction, were studied by kinetocardiographic technique before and after infusion of isoproterenol (ISP) (40 patients) or dopamine (DOP) (40 patients). 40 healthy subjects served as controls (20 for ISP and 20 for DOP). Whereas the infusion of ISP or DOP caused no abnormalities in the healthy subjects, pathological changes of the kinetocardiogram (KCG) were often induced in patients with coronary heart disease. In particular, these changes demonstrated the appearance of paradoxical outward systolic movements, reduction or disappearance of the volume effect during the ejection phase, an increase of atrial waves expressed in per cent of the total amplitude of the KCG. The abnormalities observed during the intravenous infusion of ISP or DOP were interpreted as signs of ventricular dysfunction consequent to the myocardial ischaemia induced by these amines. The use of ISP or DOP together with KCG is recommended as a diagnostic method for coronary insufficiency.

Adolescent↗