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Biomedical subjects

C Stuart

Publications and source records attributed to C Stuart.

10 recordsLinked to original sources
PubMed1992

Citrobacter diversus brain abscess: case reports and molecular epidemiology.

Citrobacter diversus brain abscess occurred in two infants in Aberdeen, 5 months apart. These are the first reported cases of this condition in the UK since 1976. Restriction endonuclease analysis with SacI enzyme showed blood and CSF isolates from both patients to be identical and different from 10 other clinical isolates of C. diversus and one C. amalonaticus strain. Furthermore, isolates of C. diversus from patients belonged to biotype "d" whereas control isolates were of biotypes "a" or "e". Because both infants attended the same central and peripheral maternity units, this raised suspicions of long term contamination of the hospital environment by this organism. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) patterns of whole-cell proteins and immunoblotting with normal human serum were remarkably homogeneous for all 13 C. diversus strains and thus were not useful for typing. However, the only C. amalonaticus strain was clearly differentiated from C. diversus strains by SDS-PAGE. Management of the infants included multiple intravenous antibiotic therapy for 4-6 weeks and repeated computerised tomography (CT) scanning and drainage of the abscess cavity. Both children survived albeit with some minor degree of brain damage.

Anti-Bacterial Agents↗
PubMed1987

The value of a combined study of carotid duplex ultrasound and oculopneumoplethysmography (OPG-Gee) in the diagnosis of carotid artery stenosis.

Two hundred consecutive carotid arteries were examined with the carotid duplex ultrasound and oculopneumoplethysmography (OPG-Gee) and compared with conventional arteriograms. The arteries were graded as normal, mildly stenotic (less than 50%), moderately stenotic (around 50%), severely stenotic (50% to 99%), or occluded. There was exact correlation between the duplex and the arteriogram as to disease severity in 70.5 per cent, good correlation in 25.5 per cent, and poor correlation in 4 per cent. When the carotid duplex was combined with an OPG-Gee, the exact correlation was 76.5 per cent, good correlation was 21 per cent, and poor correlation was 2.5 per cent. The diagnostic sensitivity of the carotid duplex alone was 95.6 per cent, diagnostic specificity was 84.3 per cent, false-positive rate was 16.2 per cent, false-negative rate was 4.2 per cent, and overall accuracy was 89.5 per cent. When the carotid duplex was combined with an OPG-Gee, the diagnostic sensitivity was 96.7 per cent, diagnostic specificity was 92.6 per cent, false-positive rate was 8.2 per cent, false-negative rate was 2.9 per cent, and overall accuracy rate was 94.5 per cent. In conclusion, when the carotid duplex was combined with an OPG-Gee, there was improvement in the exact correlation (70.5% to 76.5%), the overall accuracy (89.5% to 94.5%), and the diagnostic specificity (84.3% to 92%). The status of 15 arteries was also changed, either from moderate to mild stenosis or from possible occlusion to normal.

Arterial Occlusive Diseases↗
PubMed1979

[Farmer's lung: comparison of the teleradiographic images and computerized tomographic (CT) images].

A critical and comparative analysis between chest radiograms and CT pictures in pulmonary fibrosis of various degree, occurring in farmer's lung, reveal that the latter are apt to give a somewhat more diversified informations about pulmonary changes as simple radiography. This would prove useful in evaluating the extension and distribution of anatomical changes due to fibrotic process, although as far not able to allow an earlier diagnosis.

Aged↗
PubMed1979

Intrauterine hyperparathyroidism. Postmortem findings in two cases.

Intrauterine hyperparathyroidism is a self-limited condition seen in the neonate born of a mother with poorly controlled hypoparathyroidism. In this report, we describe the histologic findings in bone and parathyroids in twin infants with this condition who died from other causes. The skeleton showed osteopenia with evidence of increased bone turnover and defective mineralization, and there was parathyroid gland hyperplasia of the water-clear cell type. One twin died at birth, and the histologic findings were indistinguishable from those of infantile primary hyperparathyroidism; but the second twin, dying at 3 months of age, demonstrated noticeable improvement in the bone and parathyroid abnormalities.

Diseases in Twins↗
PubMedDate not supplied

[Evaluation by EMI CT 5005 Scanner of bone mineral contents variations. A proposed skeletal index for clinical use (author's transl)].

Two groups of subjects, ranging from 20 to 40 years of age the first and from 65 to 85 years the second, have been submitted to bone density measurements by EMI CT 5005 All-Purpose Scanner (140 kV; 28 mAs) and the average values compared. The difference between the average values of the two groups has been taken as a scale of points to evaluate the mineral contents of bone. By the group of older subjects the loss in trabecular bone (lumbar spine L2/L3) proved to be 59.51 EMI units, corresponding to the 47.6% of the mineral contents (p = < 0.01); the loss in compact bone (femur) was 6.6 EMI units corresponding to 5.28% of the mineral contents (p = < 5). The trabecular bone and compact bone average values added together give a whole-skeleton mineral contents index. This index applied to the group of older subjects showed a diminution of 65.81 EMI units indicating a 52.6% loss of mineral contents. Repeated measurements taken at a distance of time proved the method to be fairly reliable with acceptable degree of accuracy (+/- 5%). A tentative approach to clinical use of the skeletal index gave satisfying results.

Absorptiometry, Photon↗