[True hexobarbital tolerance].
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Anesthesia, Intravenous↗
Biomedical subjects
C Stumpf
Publications and source records attributed to C Stumpf.
Drug action on the electrical activity of the hippocampus.
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Animals↗
Postpolio syndrome--response to deprenyl (selegiline).
Two patients with postpolio syndrome are presented. The first case developed mild Parkinson's syndrome, for which she was treated with a levodopa/carbidopa combination followed by the institution of deprenyl. An unexpected improvement in the symptoms of postpolio syndrome was noted. The second patient who was unaffected by Parkinson's syndrome was started on deprenyl alone and reported a similar improvement in symptomatology.
Carbamazepine↗
Release of interleukin-6 in cultured B-chronic lymphocytic leukaemia cells is associated with both activation and cell death via apoptosis.
BACKGROUND: There is growing evidence that some cytokines promote B cell survival, while others enhance cell death. Interleukin-6 was reported to induce proliferation of chronic lymphocytic leukaemia (B-CLL) cells, and to enhance survival of these cells through inhibition of spontaneous apoptosis. MATERIALS AND METHODS: To more clearly define the effects of an in vitro stimulation of B-CLL cells, lymphocytes from 13 patients with B-CLL and from 6 healthy individuals were incubated for 7 d with immunomodulators such as interleukin-6 (IL-6), pokeweed mitogen (PWM), lipopolysaccharides (LPS), and extracts from Viscum album L. (VAL; Helixor), which were recognised to induce apoptosis but also to induce a release of pro-inflammatory cytokines such as IL-1, IL-6, and tumour necrosis factor-alpha. RESULTS: Although both, IL-6 and PWM induced a release of IL-6 and expression of the activation markers CD25 and CD71 on the surface of B-CLL cells, IL-6 did not increase or accelerate the proliferation of these cells. In contrast, VAL extracts did not result in an upregulation of activation markers or proliferation of B-CLL cells but induced both, cell death via apoptosis and IL-6 release. In response to PWM, only few clones of leukemic B cells incorporated the thymidine-analogue 5-bromo-2'-deoxyuridine. Moreover, a remarkable response of B-CLL cells towards the immunomodulators was observed only in one patient with an advanced stage. CONCLUSIONS: These preliminary results do not support theoretical objections of a B-CLL stimulation via induction of IL-6 in vitro.
Aged↗
[Clinical experiences with intracervical prostaglandin E2 administration for labor induction].
From January 1, 1986 to December 31, 1987, 119 patients among a total number of 2309 were recorded prospectively, who needed induction of labour for mixed indications (Group A), for a premature rupture of the membrane (Group B) or for medical indication (Group C). Independently of the ripe of cervix the results were significantly better in the multiparae than nulliparae respecting the success of induction, the duration of labour and the rate of Caesarean sections. 66.4% (n = 79) of all cases could be delivered within 24 hours after the first gel-application. Statistically significant differences in the partial collectives A, B, and C were seen only by unripe cervix (A = 60.0%, B = 71.4%, C = 30.0%). Repeated tries of inductions led to statistically significant more rates of Caesarean sections, fever during labour and prolonged course of labour. The rate of Caesarean sections and the fetal post-partum results comparing to the other remaining deliveries in 1986/87 were statistically not different. Side effects induced by Prostaglandins were only founded in two cases concerning nausea. Uterine hyperactivities with pathological CTG-patterns being resistant to treatment with beta-mimetics were found in one case. As severe complication the only case with particular rupture of uterus must be seen. Based on our experience the intracervical PGE2-application for induction of labour is not disadvantageous for mother and fetus, if there are certain indications and fixed criteria.
Administration, Intravaginal↗
[Effect of risk factors on premature labor and neonatal condition following delivery].
The influence of risk factors on the course of pregnancy in cases of preterm delivery, and on the mortality and morbidity of the premature infants, was investigated in a retrospective study. Data of 574 patients who bore children weighing under 2500 g between 1976 and 1986, and of a control group of 574 patients who gave birth during the same period to infants weighing over 2500 g were statistically analyzed. In the preterm population there was a significantly higher incidence of previous treatment for sterility, repeated miscarriages and prior preterm births. Smoking doubles the risk of preterm birth. Pathologic Apgar scores and acidosis morbidity were found significantly more frequently among mothers who smoked. The mortality and morbidity of the neonate depend on its birthweight and the duration of pregnancy. A considerably better prognosis may be expected if the infant weighs over 2000 g and is born after the 32nd week of gestation.
Acid-Base Equilibrium↗