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Biomedical subjects

C Sturm

Publications and source records attributed to C Sturm.

22 records · Page 2Linked to original sources
PubMed1982

Impaired response of lymphocytes from non-insulin-dependent diabetics to staphage lysate and tetanus antigen.

We examined the blastogenic responses of lymphocytes to Staphylococcus aureus antigen in 49 uninfected non-insulin-dependent diabetic subjects and in 56 uninfected nondiabetic subjects. We found a significantly decreased response to this antigen in the diabetic patients (P less than 0.05). Diabetics whose blood sugar levels were less than 150 mg/dl showed significantly decreased responses, as did diabetics whose blood sugar levels were greater than 200 mg/dl. The use of fetal calf serum in place of autologous plasma did not correct the defect. In a smaller number of patients, we observed a decreased response to tetanus toxoid, which was significant (P less than 0.05). The response to phytohemagglutinin was not significantly different from normal controls (P greater than 0.4). These results indicated that non-insulin-dependent diabetics, as well as insulin-dependent diabetics (previously reported), show decreased responses to S. aureus antigen and to tetanus toxoid. This defect apparently is not related to blood glucose levels or other serum factors.

Adult↗
PubMedDate not supplied

Fluid mechanics of left ventricular assist system outflow housings.

Using the Novacor (Baxter Novacor, Oakland, CA) Left Ventricular Assist System (LVAS) as a test bed, phasic flow patterns were analyzed for three outflow valve housing designs: 1) a triple sinus; 2) an axisymmetric concentric sinus (CS); and 3) a modified triple sinus (MS). The 21 mm Carpentier-Edwards trileaflet pericardial heart valve prosthesis was used for all experiments done on the three housing designs. The LVAS was actuated by a laboratory model of the Novacor LVAS control console, and it was connected to a mock flow loop with an adjustable afterload system to provide physiologic pressures and flows (Pao, 120/80 mmHg; pump output [PO], 2-6 L/min). Laser illuminated flow visualization techniques were used to investigate the phasic flow patterns of the housings, and the visualization derived velocity was verified by laser Doppler velocimetry at several selected points in the field. Formation of vortices behind the leaflets during the LVAS ejection phase was observed in each of the housing designs. They were well organized, and they circulated with the greatest strength in MS. These vortices tended to lie in a plane parallel to the main flow axis, with the rotational velocity increasing with the stroke volume of the LVAS. In the CS and the MS housings, a circumferential flow that provided good washing of this region was observed behind the stents.

Biomechanical Phenomena↗