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C Styles

Publications and source records attributed to C Styles.

8 recordsLinked to original sources
PubMed2006

Floppy iris behaviour during cataract surgery: associations and variations.

AIM: To assess the association of floppy iris behaviour during cataract surgery with use of alpha-1-antagonists and diabetes mellitus. METHODS: 1842 eyes of 1786 patients undergoing phacohoemulsification surgery were prospectively enrolled. The use of commonly prescribed alpha-1-antagonists and the presence or absence of diabetes mellitus were noted. The occurrence of any of the features of the intraoperative floppy iris syndrome (IFIS) was noted by surgeons blinded to the patient's history. RESULTS: 57% of patients receiving tamsulosin showed features of IFIS compared with 1% of the non-tamsulosin group (p<0.001). Of these, more than half the patients manifested the syndrome in an incomplete form. Only 1 of the 51 patients receiving other alpha-1-antagonists had IFIS. Diabetes was also not associated with IFIS (p = 1). CONCLUSIONS: Tamsulosin is significantly associated with floppy iris behaviour during cataract surgery. But not all of these patients will necessarily show all or any features of IFIS. The floppy iris syndrome is likely to represent a continuum of severity. Various undefined factors, diabetes not being one of them, may have a contributory role. Non-selective alpha-1-antagonists are unlikely to be associated with IFIS.

Adrenergic alpha-Antagonists↗
PubMed2002

MRI in the assessment of internal derangement and pain within the temporomandibular joint: a pictorial essay.

In this pictorial essay we aim to illustrate the normal temporomandibular joint (TMJ) and the common abnormalities of the osseous, cartilaginous and soft tissue components. These include disc (meniscus) displacement, deformities and perforations, abnormalities of disc and condylar movement, joint effusions, synovial proliferation, condylar deformity and erosions, degenerative change and abnormal retrodiscal enhancement.

Cartilage, Articular↗
PubMed2001

Calcification on the chest X-ray: a pictorial review.

There are numerous causes of calcification on the chest radiograph. Their striking appearance can lead to anxiety among junior medical staff. This article aims to categorize these appearances, and to give examples of the most common causes seen.

Calcinosis↗
PubMed1989

The distribution of bone metastases as shown on isotope scanning: proposed modes of spread.

Bone metastases may result from arterial, retrograde venous or direct spread. Three groups of patients; with carcinoma of lung, carcinoma of breast and carcinoma of prostate, each of approximately 50 individuals were studied to examine patterns of spread in order to relate this to the mechanism of seeding. Statistically significant differences (p less than 0.05) were observed in early bone spread in carcinoma of prostate (absence of skull involvement), carcinoma of lung (presence of posterior chest wall involvement) and carcinoma of breast (presence of anterior chest wall involvement). The results support retrograde venous reflux as being an important contributing mode of spread for carcinoma of prostate and local spread as being relevant in the early spread of carcinoma of lung and breast.

Bone Marrow Examination↗
PubMed1987

Multiple global regulators control HIS4 transcription in yeast.

Gene expression is dependent on the interaction of DNA binding factors with distinct promoter control elements to activate RNA synthesis. The expression of the HIS4 gene in yeast is under two different control systems. One of these, general amino acid control, involves a DNA binding protein, GCN4, that stimulates transcription in response to amino acid starvation by binding to 5'-TGACTC-3' sequences in the HIS4 promoter region. A second system, the basal level control, stimulates HIS4 transcription in the absence of amino acid starvation. The basal level transcription of the HIS4 gene is under the control of two genes, BAS1 and BAS2, which are also required for the control of purine biosynthesis. In addition, BAS2 is required for the utilization of organic phosphates in the growth medium. Genetic mapping and DNA sequence analysis show that BAS2 is PHO2, a gene previously identified as a regulator of phosphate metabolism. Direct biochemical analysis shows that the BAS2 gene encodes a protein that binds to both the HIS4 and PHO5 promoters. The involvement of a single DNA binding protein in the regulation of histidine, adenine, and phosphate metabolism suggests that yeast may use a few key DNA binding proteins to coordinate the regulation of diverse metabolic pathways.

Acid Phosphatase↗
PubMed1985

Phaeochromocytoma: a review of the St Vincent's Hospital, Melbourne experience (1969-84) and of recent advances in management.

Phaeochromocytoma is an unusual tumour which is eminently curable by surgical means. It is difficult to diagnose clinically because it mimics other illnesses. The clinical features of 13 cases of phaeochromocytoma diagnosed at St Vincent's Hospital, Melbourne, between 1969 and 1984 are briefly described. This review emphasizes the several major improvements in both diagnostic and localizing tests which have occurred over the 16 year period of the series. These include the clonidine suppression test and plasma and urine catecholamine estimations in diagnosis and techniques such as CT scanning and the I131-meta-iodobenzyl-guanidine scan used for localization of the tumour. Careful pre-operative preparation, based on adequate alpha blockade and intra-operative monitoring, is essential for the safe and successful removal of the tumour, which was eventually accomplished for all 12 cases in which removal was attempted. However, the most important step in the diagnosis and treatment of phaeochromocytoma is the initial consideration of the diagnosis. This step depends on the level of awareness of the disorder amongst clinicians.

Adrenal Gland Neoplasms↗