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Biomedical subjects

C Suarez

Publications and source records attributed to C Suarez.

At least 55 records · Page 3Linked to original sources
PubMed1993

Sino-nasal adenocarcinoma: epidemiological and clinico-pathological study of 34 cases.

Thirty-four cases of sino-nasal adenocarcinoma treated between 1976 and 1992 are presented. The purpose of this work is the epidemiological analysis of this disease and to put forward a classification of the lesions according to their degree of differentiation, based on the histopathological examination of 29 tumors. The risk increase of having a sino-nasal neoplasia was significant in the population exposed to wood dust in their working environment--896 times greater (540 in the male population) for adenocarcinoma and 20 times greater for squamous-cell adenocarcinoma. The proposed histopathological classification divides these lesions according to their degree of differentiation. In this series 23 well-differentiated cases were found, three moderately differentiated and three colloid-type. The five-year determinate survival of this series was 30%. The tumor stage (especially intracranial involvement) was the only significant clinico-pathological parameter that impaired the survival.

Adenocarcinoma↗
PubMed1992

Production of antimicrobials by Bacillus subtilis MIR 15.

We report the isolation and characterization of a strain of Bacillus, designed MIR 15, which appears to produce and excrete antimicrobials active against Gram-negative bacteria, but not against fungi. B. subtilis MIR 15 varied its antimicrobial profiles and production with the cultivation temperature.

Anti-Bacterial Agents↗
PubMed1991

[Safety of donors, quality of products, how much to reduce the quantity of citrate].

We examined 1,053 blood samples from 48 donors, for the effect of gradual reduction of citrate. We observed that: 1--Platelet count does not show any significant variation between 1/8 to 1/18 ratio. 2--In 13.3% of the cases, platelet clumping starts at 1/18 ratio. 3--There was no significant variation of the thrombin plasma level between 1/8 to 1/16 ratio (by measuring thrombin/ATIII complex). Our results show clearly that we can reduce the citrate ratio to 1/14 without expecting any adverse effect. Therefore we designated 1/14 as the security ratio. Parallel to this we also found that the average level +/- SD of ionized calcium is 100 +/- 10 muMol at 1/14 ratio.

Adult↗
PubMed1989

Central vestibular projections of primary cervical fibers in the frog.

The origin of cervicovestibular inputs was documented in frogs, as well as the number of fibers, site of projection, and their distribution within the nuclei. The first spinal nerve in 15 frogs was labeled with extracellular injections of horseradish peroxidase. The brain stem and the posterior root were sectioned serially. The trajectories of the fibers in the central nervous system were reconstructed, and the number and diameters of the fibers in the posterior root were determined. The average number of fibers in the first posterior root was 143 +/- 6.2, their number decreasing exponentially with increased diameter. After entering the spinal cord the fibers were located in the dorsal funiculus. The thick and medium-sized fibers coursed medially in relation to the thin ones, giving collaterals to the spinal cord and to the obex region. The thinnest fibers projected to the reticular formation and nucleus of the solitary tract. Only collaterals from fibers of medium and thick caliber reached the vestibular area in their trajectory to the cerebellum (spinocerebellar fibers). All the vestibular nuclei received collaterals and endings from the spinocerebellar fibers, the ventral nucleus being the most innervated. The total number of branches for the vestibular area, however, was very small. The results of this experiment are correlated with physiological and anatomical findings described in the literature.

Animals↗
PubMed1989

Regeneration of the eighth cranial nerve. III. Central projections of the primary afferent fibers from individual vestibular receptors in the bullfrog.

The projection site in the central nervous system of individual end-organ branches of regenerated vestibular nerves was documented in bullfrogs. The eighth cranial nerve was surgically sectioned in 12 bullfrogs (Rana catesbeiana) and allowed to regenerate. Horseradish peroxidase was used to label the primary vestibular afferent fibers from the whole nerve (one frog) and the whole anterior branch (two frogs), and the individual receptor end-organ branches to the anterior semicircular canal (three frogs), the horizontal semicircular canal (three frogs), and the sacculus (three frogs). A sufficient number of fibers from the individual receptors were labeled in nine specimens to allow a description of their central projection pattern. The overall pattern of central projections of the regenerated nerves was similar to the pattern of normal nerves. In the eighth nerve root proper and in the area proximal to the vestibular nuclei, fibers from the anterior semicircular canal were ventral, fibers from the sacculus and posterior branch were dorsal, and fibers from the horizontal semicircular canal were in an intermediate position. In ventral, superior, and descending vestibular nuclei, a projection pattern was also identifiable in some specimens. The fibers of the anterior semicircular canal projected ventral to the fibers of the horizontal semicircular canal, with fibers from the posterior branch more dorsal. The saccular fibers projected to the dorsal aspect of the ventral nucleus and the ventral aspect of the dorsal nucleus. For the most part, projections in the regenerated specimens, as verified histologically, were comparable to individual end-organ projections previously identified in normal frogs. The only major discrepancy between the findings from the regenerated specimens and those from normal frogs was in the position of the vestibular tract and the innervation to the medial nucleus. The regenerated vestibular tract was shifted laterally in the brain stem. Regenerated thick and thin fibers were intermixed in the tract and projected to the medial nucleus. Normally, the thin fibers are lateral to the thick fibers in the tract. Therefore, the regenerated afferent fibers of the vestibular nerve selectively reinnervated the vestibular nuclei, and the fibers to the individual end-organs selectively reinnervated particular parts of the nuclei. In addition, the thick and thin regenerated fibers preserved the type of bouton endings normally found. The regenerated thick fibers had rare boutons en passant and a great number of collaterals, while the thin fibers had numerous boutons en passant and only a few collaterals.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1986

Pseudo-Chediak-Higashi anomaly in a child with a hepatic vascular malformation.

A case of a congenital hepatic vascular malformation in a child complicated by disseminated intravascular coagulation and hemolytic anemia is presented. Examination of the peripheral blood disclosed the presence in the leukocytes of giant intracytoplasmic inclusions resembling those of the Chediak-Higashi anomaly. Ultrastructural analysis characterized those inclusions as phagocytosed red cell debris, a result of mechanical destruction of the red cells.

Anemia, Hemolytic↗
PubMed1985

DNA and RNA determination in 111 cases of childhood acute lymphoblastic leukaemia (ALL) by flow cytometry: correlation of FAB classification with DNA stemline and proliferation.

Flow cytometry with acridine orange was used in 111 cases of childhood acute lymphoblastic leukaemia (ALL) to determine simultaneously DNA index, cell cycle distribution and cellular RNA content in bone marrow samples. The overall incidence of DNA aneuploidy in the population was 40%. Significantly higher incidence of DNA aneuploidy was present in the L2 (70.6%) as compared to the L1 (34.1%) group (P = 0.007), using the FAB classification. No difference in the frequency of normal and abnormal DNA stemlines was found between newly diagnosed and relapsed patients. The L2 group had significantly higher proliferation (S phase = 12.4%) than L1 (S phase = 5.8%) (P = 0.01), but RNA content was not significantly different. The aneuploid group had significantly more (P = 0.01) cases with L2 morphology (28.6%) compared to the diploid group (8%) and proliferation was higher in DNA aneuploid (S-phase = 9.5%) compared to DNA diploid (S-phase = 4.7%) leukaemias. Likewise, RNA content was significantly higher in aneuploid than in diploid ALL (P = 0.006). These correlations between morphology, cell kinetics and DNA index elucidate biological properties of leukaemic cells with potentially prognostic value.

Adolescent↗
PubMed1985

Central projections of primary vestibular fibers in the bullfrog. II. Nerve branches from individual receptors.

The fibers from the nerves innervating each of the three semicircular canals and the saccule were labeled by injecting horseradish peroxidase extracellularly into these nerves. The projections into the various vestibular nuclei of each receptor were studied in transverse sections of the brain stem throughout the vestibular nuclear area. All five vestibular nuclei receive primary afferents throughout their areas. There are differences in the projection patterns of the canals. In the superior and ventral vestibular nuclei, the location of the projections depends on the crista injected. The anterior canal projects ventrally, the horizontal canal centrally, and the posterior canal more dorsally. Each canal, however, sends fibers to all areas, with overlap of fibers from the different cristae. The cerebellar nucleus receives uniform innervation from the three canals. The medial vestibular nucleus in the rostral and caudal areas receives only thin fibers from each canal, with considerable overlap. The descending nucleus in the rostral and caudal areas receives innervation from the cristae, also with considerable overlap, but with greater intensity in the ventral part of the caudal portion of the nucleus. Each crista sends fibers to the cerebellar granular layer and to the base of the cerebellar Purkinje cell layer. These fibers also innervate the reticular formation below the entry zone of the eighth nerve. The saccule innervates both the dorsal (acoustic) and the ventral nuclei, the latter in the most dorsal position. The innervation of the utricle could be ascertained only in the middle section of the descending and the medial nuclei, an area which does not receive significant innervation from the cristae. Primary afferent fibers course in the vestibular tract, forming a longitudinal bundle lateral to the vestibular nuclei. In the bundle the larger fibers are medially situated.

Afferent Pathways↗
PubMed1985

Central projections of primary vestibular fibers in the bullfrog. III. The anterior semicircular canal afferents.

A study was made of the projection patterns in the vestibular nuclei of primary afferent fibers innervating the crista of the anterior semicircular canal (ASC) of the bullfrog. Individual neurons were intracellularly recorded to characterize their spontaneous activity and injected with horseradish peroxidase to visualize their central and peripheral projections. A quantitative evaluation was made of the lengths of the central projections of primary afferents in the various vestibular nuclei and of the number of branch terminals and their precise locations in each of the major vestibular projection areas in the brain stem. The differences between the central projection patterns of the two types of primary afferent fibers were documented: the thick fibers with their irregular spontaneous activity and the thin fibers with their more regular spontaneous activity. Each neuron sends many terminals to various vestibular nuclei. The ventral part of the ventral nucleus receives the greatest number of terminals from fibers of all sizes. The medial nucleus receives terminals from the thin fibers only, while the reticular formation receives terminals exclusively from the thick fibers. All the vestibular nuclei receive innervation from ASC afferents, with considerable overlap in areas of innervation between fibers of different caliber. Differences were found between the thick and thin fibers in their locations, their patterns of branching, and the appearance of their terminal boutons. These anatomic characteristics are interpreted to represent physiologic differences in the production of reflexes by thick and thin neurons. It is also postulated that these different neurons play different roles in vestibular system function: thick neurons contribute to the maintenance of equilibrium during movement while thin neurons participate in the maintenance of posture and vestibular tonus.

Animals↗
PubMed1984

Accidental carbon monoxide poisoning.

In this case report of an accidental automobile carbon monoxide poisoning, we identify the following risk factors: freezing temperature, young passenger age, location in the rear of the auto, smaller patient mass, and auto disrepair. The pathogenesis of carbon monoxide poisoning is reviewed. Emergency treatment and suggested criteria for hyperbaric oxygen use in pediatric patients are discussed.

Accident Prevention↗
PubMed1983

Value of two-dimensional echocardiography in endomyocardial disease with and without eosinophilia. A clinical and pathologic study.

Ten patients (six women and four men) with endomyocardial disease, four with and six without hypereosinophilia, were studied by two-dimensional echocardiography (2-D echo). Eight had biventricular congestive heart failure and two had atypical chest pain with ischemic electrocardiographic changes. The patients were 15-50 years old (mean 40 years) and duration of illness was 2-9 years (mean 4.4 years). Nine had cardiac catheterization and three pathologic examination. Characteristic 2-D echo findings included apical obliteration of one or both ventricles by echogenic material suggestive of fibrosis or thrombosis; bright, specular echoes at the cavity surface of the apical obliteration suggesting patchy calcification; preserved left apical systolic inward motion, which differed significantly from the dyskinetic motion of thrombotic apical obliteration of ischemic or Chagasic origin (p less than 0.001); involvement of the papillary muscles and posterior atrioventricular valve; preserved ventricular contractile function in most patients; and the combination of normal-to-small ventricles with large atria. None of 14 subjects with secondary hypereosinophilia followed for 15.4 months developed similar 2-D echo findings. We conclude that both forms of endomyocardial disease had a 2-D echo pattern useful for noninvasive recognition and differentiation from patients who have valvular heart disease, constrictive pericarditis and cardiomyopathies of other origins.

Adolescent↗
PubMed1982

Pulmonary vein to systemic artery missile embolus.

Pulmonary vein to artery missile embolus is extremely rare. Only one other case could be found in the world's literature and the present case appears to be the only reported survivor. The key in the safe management of missile embolus is in the prompt and proper care of the primary wound. Extraction of the foreign body is secondary and becomes an absolute necessity only when it interferes with distal perfusion. Catheter embolectomy is contraindicated because of possible intimal damage, so that direct arteriotomy is preferred.

Adult↗
PubMedDate not supplied

Cost-effectiveness of enoxaparin as thromboprophylaxis in acutely ill medical patients in Spain.

OBJECTIVE: The objective of this study was to determine the cost-effectiveness of thromboprophylaxis with enoxaparin versus no thromboprophylaxis in patients with acute medical illness in Spain from the society perspective. METHODS: Markov process analysis techniques were used to model the health economic outcomes. Clinical data were derived mainly from the MEDENOX trial, while health-care utilization was derived from Delphi panels. RESULTS: An analysis over the MEDENOX trial period shows that the cost per event avoided is currency 432, while the cost per life saved is currency 1527. The cost per event includes all medical resource utilization costs associated with the event. The lifetime model, which assumes no higher risk for recurrence of venous thromboembolism (VTE) and mortality in asymptomatic patients, shows that the use of enoxaparin leads a cost per event avoided of currency 270 and cost per life-year gained of currency 71. If the lifetime model assumes a higher risk for recurrence of VTE in asymptomatic patients, enoxaparin is dominant over no thromboprophylaxis. CONCLUSION: The results showed that the favorable clinical benefit of enoxaparin as thromboprophylaxis in patients with acute medical illness, which was observed in the MEDENOX trial, results in a positive health economic benefit in both the short term and the long term in the health-care setting of Spain.

Acute Disease↗