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Biomedical subjects

C Sulman

Publications and source records attributed to C Sulman.

At least 19 recordsLinked to original sources
PubMed1990

Thyrotropin binding inhibitory immunoglobulin (TBII) and thyroid diseases using ROC analysis.

At attempt to detect the auto-immune origin of hyperthyroidism may be made by measuring thyrotropin binding inhibitory immunoglobulin (TBII) which uses the antibodies ability to inhibit labelled TSH binding to the TSH receptor. This study was carried out on 196 patients of which 128 had autoimmune hyperthyroidism and 68 another thyroid disease. Construction of receiver operating characteristic (ROC) curves allowed us to show the quality of the assay. This method, according to the prevalence of the disease, helped to determine the ideal cut-off of the assay. This cut-off was between 13.5 and 7.5% for prevalences ranging between 10 and 80%. For a 9% cut-off, which corresponded to the group studied, we observed 87.5% sensitivity and 87% specificity. Existence of false positives and false negatives was linked to the assay method which only informed us about the occupation of the TSH binding site and not its physiological activity. However, we concluded this easy to perform assay is a good test for the diagnosis of autoimmune hyperthyroidism.

Autoantibodies↗
PubMed1989

[Clinically localized cancers of the breast. Therapeutic consequences of the evaluation of extension].

The therapeutic modifications induced by pretreatment evaluation were studied in a consecutive series of 852 asymptomatic women with newly diagnosed primary breast cancer attending our center between 1980 and 1984. Staging tests included chest X-rays in 851 patients, bone X-rays in 831, alkaline phosphatase in 826, hepatic enzymes in 818, liver echography in 750 and bone scintigraphy in 504. The intended local treatment was changed for a systemic one in 8 patients due to suspicious abnormalities. The follow-up confirmed evidence of metastases in 6 out of 8 patients (bone: 4; liver: 1; lung: 1). Mastectomy, initially avoided in these 6 patients, was subsequently performed in 2 of them owing to slow progression of distant metastases. On the basis of the current study, pretreatment staging in asymptomatic primary breast cancer cannot be recommended due to the low prevalence of detectable metastases.

Adult↗
PubMed1987

[Value of the assay of squamous cell carcinoma in cancer of the uterine cervix].

The squamous cell carcinoma (SCC) antigen was assayed by radioimmunoassay in patients with squamous cell carcinoma of the uterine cervix at different stages before any treatment and in patients under treatment. Low levels of SCC antigen were detected in the early stages of the disease, showing that this antigen cannot be considered an aid to diagnosis. In the more advanced cancers, an increase of SCC antigen levels proportional to the stage of the disease was observed. However, SCC antigen assays are mainly useful in the follow-up of patients to evaluate therapeutic effectiveness.

Antigens, Neoplasm↗
PubMed1985

[Evaluation of the severity of coronary disease by thallium 201 myocardial scintigraphy and technetium 99m isotope ventriculography. Comparison of the 2 methods apropos of 30 cases].

The evaluation of the severity of coronary artery disease by non-invasive methods may involve the use of isotope techniques. The authors compared the results of technetium 99m cardiac functional angioscintigraphy and thallium 201 myocardial scintigraphy, performed at rest and on effort, in a group of 30 patients. The 30 patients consisted of 6 normal patients (control group) and 24 patients with coronary artery disease (8 cases of angina; 16 infarcts, including 12 inferior infarcts). Coronary angiography revealed 13 cases of one vessel disease, 8 cases of two vessel disease and 3 cases of three vessel disease. The results of angioscintigraphy revealed that the technique was reliable in terms of the evaluation of the abnormalities of contraction (sensitivity: 96%, compared with the results of haemodynamics) and that the study of the ejection fractions at rest and on effort was particularly valuable. The ejection fractions calculated by the isotope method were not statistically different from the ejection fractions calculated by the haemodynamic method. The patients with one vessel disease and the normal subjects increased their ejection fraction on effort by about 12% (p = 0.03), in contrast with the patients with multiple vessel disease, who increased their ejection fraction on effort by 2% (p greater than 0.05). In contrast, the results of myocardial scintigraphy at rest and on effort were disappointing. The method was specific (100%), but in our series, its sensitivity was only 72% for the group of patients with coronary artery disease. In cases with infarction and multiple vessel disease, the zone of the infarction was always detected, but no other abnormalities were observed in the other territories.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

Value of the estimation of thyroglobulin levels in the surveillance of treated differentiated thyroid carcinoma.

Thyroglobulin levels were measured, without interruption of hormone treatment, in 115 patients who had undergone thyroidectomy for differentiated carcinoma. Thyroglobulin levels were invariably high in patients with iodine fixing metastases. The estimation of thyroglobulin was found to be more sensitive than the detection of metastases by their uptake of 131 iodine. A new protocol is suggested for monitoring treated differentiated carcinoma.

Adolescent↗
PubMed1980

[Quantitative bone scintigraphy in the study of the sacroiliac joint in chronic inflammatory rheumatism].

Scintillation counting of the sacro-iliac bones using technetium pyrophosphate or diphosphate is a simple examination without danger. The uptake opposite each sacro-iliac bone is assessed by reference to that of the lumbar spine visible on the film. A study of a control group of 81 subjects permits one to determine the existence of variations in relation to age: the fixation is high in subjects under the age of 20 years and reduced in adults aged over 50 years. The 44 controls from 20 to 50 years, permit one to retain as reference value, the ratio 1.14 for the right sarco-iliac bone and 1.11 for the left sarco-iliac bone with a confidence interval of 0.13. There was noted a significantly high uptake during arthritis. Whether this was the axial form (40 cases) or the peripheral from (7 cases) and during Reiter's syndrome (15 cases). This hyperfixation was more frequent and more important when the sacro-iliac involvements (whether accompanied or not by radiological signs) were the cause of inflammatory pain. Increased uptake was also noted during other forms of chronic inflammatory rheumatism: rheumatoid arthritis (10 cases). Chronic inflammatory rheumatism (unclassifiable) 20 cases. It thus seems that one may retain in many cases the existence of sacro-iliac inflammatory changes without the latter being necessarily accompanied by clinical or radiological signs. The discovery of hyperfixation of the sacro-iliacs during chronic inflammatory rheumatism is further evidence in favour of the diagnosis of sacro-iliac arthritis but should be interpretated in the light of the general context.

Adolescent↗
PubMed1975

[Value and limitatious of scintigraphy of the sacro-iliac joints using technetium pyrophosphate].

Scintigraphic exploration of the sacroiliac (S.I.) joints by 99 m-technetium pyrophosphate is simple and free of all danger. The fixation of the isotope in the right sacroiliac (R.S.I.) and the "normal" limits of the fixation ratios R.S.I./L.R. and the lumbar rachis (L.R.), visible on the same film. A series of 28 controls having made it possible to calculate the "normal" limits of the fixation ratios R.S.I./L.R. and L.S.I./L.R., the isotopic fixation was measured in 25 patients with sacroiliac inflammation, 21 of whom were rheumatic, 3 infectious. It was shown that scintigraphy could yield useful information on the evolution of sacroiliac inflammation, making an early diagnosis possible, and also contributing to differentiation between rheumatic and infectious inflammation.

Adult↗