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Biomedical subjects

C Sundaram

Publications and source records attributed to C Sundaram.

12 recordsLinked to original sources
PubMed1991

Diagnostic utility of fine-needle sampling without aspiration: a prospective study.

Fine-needle sampling without aspiration (FNS) was done in 100 consecutive patients with 109 palpable masses. Its efficiency in obtaining adequate material is compared with conventional fine-needle aspiration cytology (FNAC) and found to be 80% with either method. FNS shows a diagnostic accuracy that correlates well with FNAC and histopathology. Malignant lesions are sampled more easily. Anatomic site has no influence on the yield. Most of the negative cases are small swellings, less than 1.5 cm in diameter. It is more cost effective than FNAC. Trauma to the tissues and the resultant artifacts are less. It is relatively painless and can safely be applied to many areas, including some sensitive sites.

Adolescent↗
PubMed1990

Anaplastic astrocytoma of the spinal cord presenting with features of raised intracranial pressure.

Intramedullary tumors of the spinal cord in childhood are usually of low grades (grades I and II) and are most commonly seen in the cervical and cervicothoracic regions. They present with symptoms and signs of spinal cord tumor. It is uncommon to find an anaplastic astrocytoma situated in the thoracolumbar segment of the spinal cord. Whereas papilledema and raised intracranial symptoms have been reported in about 12.5% of cases of spinal cord tumors it is rare to find them presenting initially only with symptoms of raised intracranial pressure and only later followed by spinal cord symptoms. The case of an 11-year-old female child is reported here because of a combination of these two rare features.

Astrocytoma↗
PubMed1990

The effect of UV radiation and sun blockers on free radical defence in human and guinea pig epidermis.

Defence against oxidative damage by UV-generated free radicals in both guinea pig and human skin has been found to be mediated by the ubiquitous thioprotein, thioredoxin reductase. Human keratinocytes contain approximately 5% thioredoxin reductase in their total acidic protein fraction and also express membrane-associated enzyme activity in cells cultured in synthetic medium. The thioredoxin reductase/thioredoxin system has been shown to reduce superoxide anion radicals through hydrogen peroxide to water. However, both UVA and UVB radiation, below the minimal erythemal dose, generate a sufficiently high concentration of oxygen radicals to deactivate thioredoxin reductase considerably. In albino guinea pigs, enzyme deactivation was up to 70% for UVA and 66% for UVB (n = 10 animals/protocol). The application of sun blockers SPF4, SPF8 and SPF15 to albino guinea pig skin offered no significant protection for the deactivation of thioredoxin reductase by either UVA or UVB radiation. In the human population (n = 15), thioredoxin reductase was deactivated by 54% with UVA and 36% with UVB radiation, although the degree of enzyme inhibition depended on skin phototype (I-VI, Fitzpatrick Classification). SPF24 offered considerable protection for thioredoxin reductase against both UVA and UVB for skin types I and II. However, SPF24 yielded no significant protection with UVA for skin types III-VI, and enhanced the enzyme inhibition with UVB additively. These results indicate that UVB photo-oxidation of oxybenzone (the UVA filter in SPF24) may deactivate thioredoxin reductase in more pigmented members of the population by Michael addition of oxybenzone semiquinone to the thiolate active site of this enzyme.

Adult↗
PubMed1990

Posterior mediastinal paravertebral hydatid cyst presenting as spinal compression. A case report.

A primary posterior mediastinal hydatic cyst presenting with spinal compression syndrome is rare. We describe the case of a 35-year-old lady with a posterior mediastinal hydatid cyst who presented with progressive paraplegia. Excision of cyst was followed by systemic Albendazole therapy. She showed neurological recovery without recurrence till now. The role of Albendazole in preventing recurrence has been stressed and the relevant literature has been reviewed.

Adult↗
PubMed1990

Hepatitis B surface antigen, hepatocellular carcinoma and cirrhosis in south India--an autopsy study.

This study is aimed at finding the association of hepatocellular carcinoma and cirrhosis with hepatitis B surface antigen in a particular geographical area, Andhra Pradesh State in South India. In total, 206 cases of autopsy livers were studied for the presence of hepatitis B surface antigen by orcein staining. Of the 114 cases of cirrhosis 67.54% were positive for the antigen. There were 13 cases of macronodular, 55 cases of mixed and 46 cases of micronodular cirrhosis. The antigen positivity was 100%, 98.7% and 21.74% respectively. The difference in positivity between micronodular and the other two types of cirrhosis was statistically significant (P less than 0.01). Of the 58 cases of hepatocellular carcinoma, 50 were associated with cirrhosis. In 80% of these cases, hepatitis B surface antigen was demonstrated, whereas 75% of cases of hepatocellular carcinoma not associated with cirrhosis, were positive for hepatitis B surface antigen. The geographical importance of these findings was discussed.

Carcinoma, Hepatocellular↗