Biomedical subjects

C T Chiu

Publications and source records attributed to C T Chiu.

74 records · Page 5Linked to original sources

PubMedDate not supplied

Non-functioning islet cell tumors of the pancreas--a multicentric clinical study in Taiwan.

BACKGROUND/AIMS: Islet cell tumors of the pancreas are rare. Functioning tumors are characterized by the symptoms induced by the hormones they secrete. The clinical behaviors of non-functioning tumors are quite different. In this retrospective study, we scrutinized 16 patients with non-functioning islet cell tumor in three tertiary university hospitals in Taiwan during a 20-year period. METHODOLOGY: There were 12 women and 4 men with a mean age of 47 years. Body-weight loss, abdominal pain and palpable mass were the most frequent symptoms. RESULTS: The mean size of these tumors was 8.9 cm in diameter. Ten tumors were located at the tail of pancreas, the other 6 located at the head. Except for hyperbilirubinemia in 2 patients, none of the patients with non-functioning islet cell tumor showed abnormalities of laboratory data including serum tumor markers. Preoperative detection of these tumors by imaging modalities was not difficult due to the large size of the tumors. However, differentiation with functioning tumor or ductal cell carcinoma required clinical and imaging correlation. Fourteen tumors were malignant including 8 with regional lymph nodes involvement, 3 with locally microscopic invasion, 2 with hepatic metastasis and 2 with nearby organ invasion. CONCLUSIONS: Even with its malignant behavior, non-functioning islet cell tumor still possessed a good prognosis after adequate surgical removal in comparison with a higher mortality rate of ductal carcinoma of the pancreas.

Adenoma, Islet Cell↗

PubMedDate not supplied

Surgical results for severe acute pancreatitis--comparison of the different surgical procedures.

BACKGROUND/AIMS: We compared the outcome of surgery for the patients with severe acute pancreatitis using different surgical procedures to find risk factors for mortality. PATIENTS AND METHODS: Records of eighty six patients with severe acute pancreatitis who underwent different surgical procedures in the past five years were retrospectively reviewed. RESULTS: The patients were found to have severe acute pancreatitis during operation. The morbidity and mortality of three different surgical procedures were compared. The risk factors related to the mortality were analyzed. Thirty one patients considered as group A received debridement and closed sump drainage. Forty patients considered as group B receiving necrosectomy with open packing of the peripancreatic space. The other 15 patients considered as group C received debridement and continuous lavage of the lesser sac. The patients in group A had highest mortality (48.4%) and those in group B had lowest (15%). CONCLUSIONS: The significant risk factors of mortality included high Ranson's signs, peripancreatic necrosis, pancreaticogenic ascites and bacterial infection. The open packing or marsupialization of group B provided an easy way to perform repeated debridement after the first operation, resulting in the lower mortality for severe acute pancreatitis than other surgical procedures. The procedure with closed sump drainage resulted in higher incidence of postoperative bleeding and sepsis. The patients with higher Ranson's signs, peripancreatic necrosis, pancreatic ascites or positive bacterial infection should be treated more aggressively.

Acute Disease↗