Biomedical subjects
C T Flear
Publications and source records attributed to C T Flear.
Changes in extracellular fluid after trauma.
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Evaluation of new perfusion solution for kidney preservation.
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Electrolyte changes in the human myocardium after anoxic arrest.
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Electrolyte and body water changes after trauma.
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The effect of Escherichia coli endotoxin on extracellular fluid volume.
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The effect of Escherichia coli endotoxin on membrane permeability in skeletal muscle.
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Crystalloid administration in shock and surgical trauma.
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Alterations in water and electrolyte distribution in congestive heart failure and their significance.
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Observations on water and electrolyte changes in skeletal muscle during major surgery.
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Does plasma from shocked or uraemic dogs contain a factor which increased permeability of skeletal muscle-cell membranes?
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Experimental haemorrhagic and endotoxic shock in dogs: evidence for imbalance in exchanges of water and solutes across cell membrane.
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Water and electrolytes in muscle.
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Water, sodium, potassium, and chloride content of skeletal muscle in fit and ill subjucts.
Biopsies of deltoid, gastrocnemius, or rectus abdominis taken under general anaesthesia from each of 15 subjects have been analysed for fat, water, sodium, potassium, and chloride. Some 110 samples were analysed for each muscle, and all the estimations were made on each sample. Standards have been constructed for the normal composition of these three muscles, and their reliability is discussed. Data from subjects with peptic ulcer, hyponatraemia, and sustained weight loss must be excluded from standards. It seems likely that standards could be improved by taking age and sex into account.
Why does the plasma sodium level fall after surgery?
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The volume of extracellular fluid (E.C.F.) in skeletal muscle.
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Exchangeable body potassium and sodium in patients in congestive heart failure.
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Acute biochemical responses to moderate beer drinking.
The consequences of drinking six pints of beer (3.31) over three hours were investigated in six healthy men. The expected rise in plasma osmolality, fall in plasma vasopressin concentration, and increase in free water clearance occurred; these variables had returned to normal by nine hours. There was a small but significant fall in plasma concentrations of urea and creatinine accompanied by a rise in plasma potassium concentration. Serum activities of alkaline phosphatase, gamma-glutamyl transferase, creatinine kinase, and lactate dehydrogenase did not change, and there was no alcohol-induced hypoglycaemia. All subjects had a slight hangover, but none was fluid depleted. It is concluded that, apart from inducing changes in water balance, alcohol in this form causes remarkably little metabolic disturbance.