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Biomedical subjects

C T Miller

Publications and source records attributed to C T Miller.

At least 37 records · Page 2Linked to original sources

Obstetric patients who select and those who refuse medical students' participation in their care.

PURPOSE: To assess attitudes and expectations of obstetric patients toward the involvement of medical students in their care. METHOD: At the Medical Center Hospital of Vermont in 1991, questionnaire responses were collected from 222 obstetric patients who had been assisted by clerkship students from the University of Vermont College of Medicine and 78 patients who had refused the participation of students. The responses were analyzed for differences in demographic backgrounds, prior hospital experiences, and general expectations of student involvement, using chi-square, two-tailed t-tests and analysis of variance. RESULTS: Both groups of respondents consisted primarily of young, well-educated, married women, who appear to have made their decisions about student participation by balancing their personal needs and their sense of altruism. For example, 61% of those who had refused the participation of students ranked the desire for privacy as their primary reason, whereas 73% of those who had accepted student participation ranked as their primary reason the desire to contribute to a student's education. Although both groups of patients expected the students to perform few clinical procedures, the patients who had refused student participation expected the students to be more involved in patient care than did the patients who had allowed participation. Of the 25% of the patients who had had students involved in prior pregnancy care, those who had currently refused student participation had less positive views of prior student care. CONCLUSION: Patients' needs for privacy, past experiences with student care, and expectations of student performance should be considered to ensure the respectful incorporation of student involvement in obstetric care.

Altruism↗

Preschool siblings of handicapped children: interactions with mothers, brothers, and sisters.

The purpose of this investigation was to examine similarities and differences between young (aged 3 years to 6 years 9 months) siblings of handicapped and nonhandicapped children in their behavioral interactions with their mothers, brothers, and sisters. Behavior of mothers toward the different groups of children also was examined. Results revealed few differences between sibling groups in the quantity or quality of their interactions with family members. In comparison to the matched control children, siblings of handicapped children engaged in more parallel play and social play, and were more nurturing but no more likely to interact aggressively or to be commanding or directive with their brothers or sisters. Mothers in the experimental group were found to target significantly more nurturant behaviors toward their children compared to control mothers and were significantly more likely to deliver commands, directives, and reprimands to siblings of handicapped children than to any other child. Results are discussed in terms of their correspondence to previous observational and interview research.

Child↗

Discrete vortex methods for the simulation of boundary layer separation effects on worker exposure.

The discrete vortex method is a numerical technique for the solution of the two-dimensional Navier-Stokes equations in vorticity-transport form. The technique is employed here, with appropriate modifications, to simulate boundary layer separation around a worker and to assess the implications for exposure. Approximations include: (1) representation of the worker as a two-dimensional elliptical cylinder; and (2) contaminant transport by vortex shedding exclusively. The model results in estimates of breathing zone concentration that are in reasonable agreement with laboratory wind tunnel experiments.

Air Movements↗

Social interactions of obese and nonobese women.

The stigma associated with obesity is likely to limit the opportunities obese women have to develop social skills. This hypothesis was tested by having obese (n = 15) and nonobese (n = 22) women converse on the telephone with college students who were unaware of the women's weights. Ratings made by judges who listened to the women's contributions to the conversations but who were unaware of their weights showed that obesity was negatively related to judgments about the women's likability, social skills, and physical attractiveness. The telephone partners of obese women rated the women and themselves more negatively than did the partners of nonobese women. Obese and nonobese women generally did not differ in their evaluations of their own and their telephone partners' behavior, and they also did not differ on a measure of social self-esteem. These findings suggest that there are real differences in the social behavior of obese and nonobese women and that these differences affect the impressions formed by those with whom they interact.

Adult↗

What mentally retarded and nonretarded children expect of one another.

Twenty mentally retarded students and nonretarded students matched for chronological age (n = 20) or mental age (n = 16) made judgments about children described as having or not having learning problems. Results showed that students had both positive and negative stereotyped expectations about these children and that there were few differences between the expectations of retarded and nonretarded students. Students' responses to stereotype questions 11 to 18 months later revealed few changes in their stereotypes and no significant differences between stability of retarded and nonretarded students' stereotypes. Results suggest that understanding social relations between retarded and nonretarded children requires consideration of the expectations of both groups.

Adolescent↗

Psychosocial characteristics of preschool siblings of handicapped and nonhandicapped children.

This project examined psychosocial characteristics of 24 preschool-aged siblings of handicapped children in relation to a control group of 22 siblings of nonhandicapped children. Subjects were matched on family size and income, sibling age, birth order, sex, age spacing, and marital status of their parents. Results indicated no statistically significant differences between groups of children on measures of perceived self-competence and acceptance, understanding of developmental disabilities, empathy, and child care responsibility. Significant group differences were found where brothers of handicapped children were rated by their mothers as being more depressed and aggressive than brothers of nonhandicapped control children. Sisters of handicapped children were rated by mothers as being more aggressive than sisters of nonhandicapped children. Sisters of handicapped children and brothers of nonhandicapped children had significantly fewer privileges and more restrictions on their home activities than other groups. Results are discussed in relation to previous research on older siblings of handicapped children and the general literature on family stress and childhood disability and disease. The importance of examining sibling functioning via multiple measures of child behavior is stressed.

Aggression↗

Methylmercury-induced mitochondrial DNA synthesis in neural tissue of cats.

The association between selected neuropathological lesions and effects on mitochondrial and nuclear DNA synthesis was explored in cats exposed in vivo to methylmercuric chloride. Two groups of eight adult female cats ingested 0 or 176 micrograms Hg/kg body wt/day as methylmercuric chloride added daily to their diet. Treated animals and concurrent controls were sacrificed following the onset of clinical signs of toxicity, with the mean termination time being about 12 (range 7-15) weeks. Terminal Hg levels for the control and treated groups respectively were 0.16 +/- 0.02 and 12 +/- 1 ppm in the cerebrum and 0.16 +/- 0.01 and 14 +/- 1 ppm in blood. Hydroxyurea-resistant [3H]thymidine incorporation into DNA in cultured explants of cerebrum and cerebellum, as measured by scintillation counting of extracted DNA, was elevated for treated animals. Autoradiographic analysis indicated that the excess DNA synthesis was cytoplasmic, and deoxyribonuclease resistant, suggesting a mitochondrial DNA origin. The excess DNA synthesis was pronounced in cell types prone to neurodegeneration, specifically the Purkinje cells and the granular cell layer in the cerebellum and the large neurons in the cerebrum. Mitochondrial DNA from neural tissues of an additional five pairs of cats treated for 8 weeks was isolated from cesium chloride/ethidium bromide density gradients. Thymidine incorporation into mitochondrial DNA was greater in methylmercury-treated than control animals. These observations indicate that methylmercury affects mitochondrial DNA synthesis in vivo with a tissue specificity parallel to that of neuropathological lesions.

Animals↗

Effects of saccharin and urine on the decomposition of N-nitrosomethylurea.

Addition of either saccharin or rat urine to aqueous N-methyl-N-nitrosourea (MNU) caused concentration-dependent loss of the ultraviolet absorption of MNU. The shapes of the absorption spectra of the residual MNU products were different and characteristic of either saccharin (flat-sided) or urine (symmetrical) as reaction matrix. In the presence of urine from rats fed 2.5% saccharin in the diet, the flat-sided curve characteristic of MNU-saccharin products was always observed. Further, the half-life of the MNU products in urine from saccharin-treated rats was shorter than the half-life observed in control urine, suggesting that saccharin ingestion might alter both the nature and rate of MNU decomposition in vivo. A molecular hypothesis for the mechanism of the MNU/saccharin interaction is proposed.

Animals↗

High school students' attitudes and actions toward "slow learners".

The relationship between high school students' attitudes and their involvement in their school's peer-tutoring program for "slow learners" was examined. Predictions about how attitudes would be related to behavior were derived from theories about attitude-behavior consistency. Results showed, as predicted, that students' attitudes toward people who receive tutoring were unrelated to their peer-tutoring behavior, whereas there was a trend for their attitudes toward their own tutees to predict whether they met with their tutees. Consistent with Ajzen and Fishbein's (1973) theory, however, the best predictor of peer-tutoring behavior was students' intentions to tutor. Moreover, both intentions and behavior were correlated with students' attitudes toward this behavior. These results were interpreted as demonstrating the value of using an empirical validated theoretical approach to predicting behavior toward slow learners.

Adolescent↗

Unscheduled DNA synthesis in human leucocytes after a fish (amine source) meal with or without salad (nitrite source).

Increased unscheduled DNA synthesis (UDS) was observed previously in leucocytes from human volunteers after various meals containing nitrite from cured meats and vegetables. To explore further the role of ingested nitrite, UDS response was measured in human leucocytes after a meal of bread, butter and cod fish alone (amine source) or bread, butter and cod fish plus a salad of lettuce, radish and spinach (nitrite source). A cross-over design was used so that all subjects (10 male, 10 female) were tested after both meals. Salad (nitrite source) had no effect on the level of UDS after the meal; however, UDS increased after the meal with or without salad for trial 1, but decreased for trial 2. The difference between trials could not be accounted for by sources of variation such as differences between individuals or experimental technique. The factor(s) responsible for this significant difference between trials must be associated with the non-salad components of the meal.

Amines↗

Mutagenicity induced by lyophilization or storage of urine from isoniazid-treated rats.

Urine collected during 24 h after treatment of rats with 90--550 mg/kg isonicotinic acid hydrazide (isoniazid, INH) was after lyophilization, mutagenic for Salmonella typhimurium TA1535. Urine collected directly from bladders of INH-treated rats was not mutagenic, and solutions of INH in water or urine became mutagenic only after lyophilization. In the absence of lyophilization, sterile urine from INH-treated rats became mutagenic after 8--14 days' storage at room temperature.

Freeze Drying↗

Cellular reactions of O6-methylguanine, a product of some alkylating carcinogens.

Cultures of a purine-requiring mutant of Chinese hamster ovary cells (CHO-104b), randomly bred hamster embryo cells, or Escherichia coli B(s-1) were treated with non-toxic doses of (3)H-labelled O(6)-methylguanine. DNA and RNA were isolated and subjected to enzymic digestion to nucleosides at pH8. The products of digestion were analysed by ion-exchange chromatography on columns of Dowex 50 (NH(4) (+) form) at pH8.9. No (3)H-labelled O(6)-methylguanosine was detected in nucleic acid digests. (3)H-labelled O(6)-methylguanine was O-demethylated yielding [(3)H]guanine in CHO-104b cells. Radioactivity in nucleic acid digests was associated with thymidine, guanosine, deoxyguanosine and an unidentified early-eluting product. Reports of similar unidentified products from nucleic acids labelled with various agents are discussed.

Animals↗