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Biomedical subjects

C T Samuell

Publications and source records attributed to C T Samuell.

21 records · Page 2Linked to original sources

A study of glycosaminoglycan excretion in normal and stone-forming subjects using a modified cetylpyridinium chloride technique.

Precipitation with cetylpyridinium chloride followed by hexuronic acid assay has been used to study glycosaminoglycan excretion in normal subjects and calcium stone formers. It was found necessary to concentrate dilute urines prior to assay to achieve satisfactory precipitation of the glycosaminoglycans. No significant differences in daily glycosaminoglycan excretion were detected between normal and stone-forming subjects.

Cetylpyridinium↗

Uromucoid excretion in normal subjects, calcium stone formers and in patients with chronic renal failure.

Using an electroimmunoassay technique for uromucoid in urine, the excretion of this protein has been studied in normal subjects, calcium stone formers and in patients with chronic renal failure. In the normal subjects there was no significant difference in daily excretion between males and females, but a positive correlation with urine volume was demonstrated for this group. No significant difference in daily uromucoid excretion was found between normal and stone forming subjects. In the presence of chronic renal failure uromucoid excretion was found to be reduced and correlated with overall renal function as assessed by creatinine clearance.

Adult↗

A modified electroimmunoassay technique for uromucoid in urine.

An electroimmunoassay technique for the estimation of urine uromucoid has been studied in an effort to improve its performance. It was found that strict attention to specimen collection, preservation and storage was important. The conditions used for the production of immunologically active uromucoid subunits utilising sodium dodecyl sulphate were found to be critical, needing rigid standardisation if acceptable precision is to be achieved.

Evaluation Studies as Topic↗