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C Tóth

Publications and source records attributed to C Tóth.

At least 19 recordsLinked to original sources
PubMed2002

A novel method of introducing hydrophobic moieties into oligonucleotides for covalent and non-covalent immobilization on electrode surfaces.

An effective method for the introduction of oleylamine-modified cytidine units into predetermined position(s) of the oligodeoxyribonucleotide (ON) chain during automated ON synthesis has been developed. The high yields of the condensation products upon the introduction of the modified units allow the methods suggested to be used for the synthesis of ONs with two hydrophobic substituents. We also suggest a simple method for obtaining ONs with 5'-terminal hydrophobic linker with free thiol group. The functionality of synthesized ON modified by thiol group and that with hydrophobic spacer for the detection DNA hybridization has been approved in conductometric experiments.

Base Sequence↗
PubMed2002

Quantitative assessment of blood flow reserve using 99mTc-HMPAO in carotid stenosis.

Dynamic imaging of the inflow of technetium-99m hexamethylpropylene amine oxime (HMPAO) to the brain has been proved to allow estimation of the hemispherical cerebral blood flow (CBF) using the Patlak plot. In this study, we compared the hemispherical CBF (in ml/min/100 g) of different patient groups. A total of 25 patients (comprising 13 with migraine and 12 scheduled for endarterectomy owing to angiographically confirmed severe stenosis of the internal carotid artery on at least one side) underwent baseline and acetazolamide 99mTc-HMPAO brain perfusion studies. In addition, acetazolamide 99mTc-HMPAO studies were performed in 12 healthy subjects (no baseline study was performed for ethical reasons.) Dynamic studies were acquired by means of a dual-detector gamma camera with a large field of view (HELIX, Elscint). Special difference images were created to make definition of the aortic arch and hemispherical brain regions easier and more reproducible. A semi-automatic method was developed to determine the transit time from the aorta to the brain, making the generation of the Patlak plot even more robust. The baseline CBF values did not significantly depend on the disease (P>0.1), whereas the CBF values obtained after acetazolamide provocation did do so (ANOVA, P<0.001). Patients suffering from migraine showed a significant increase in global CBF values after acetazolamide provocation (paired t test, P<0.05), but we could not find any effect of the provocation in patients awaiting carotid endarterectomy, indicating a lack of cerebrovascular reserve capacity. Comparison of the results of the acetazolamide study in patients and the control group revealed the CBF values to be significantly lower in patients with carotid stenosis (two-sample t-test, P<0.001), but not in those with migraine (P>0.1). In summary, using quantitative analysis of 99mTc-HMPAO brain studies we could objectively compare the CBF of patients suffering from different diseases. Especially the CBF values obtained after acetazolamide provocation permitted effective differentiation of disease states. The quantitative results may be of assistance in therapy planning, e.g. in selection of the correct operative technique.

Acetazolamide↗
PubMed2002

Simultaneous bilateral compared with unilateral percutaneous nephrolithotomy.

OBJECTIVE: To compare simultaneous bilateral percutaneous nephrolithotomy (SBPCNL) and unilateral PCNL in separate sessions in patients with bilateral renal stones for several variables before and after surgery. PATIENTS AND METHODS: The results from SBPCNL carried out at two centres in different countries on 198 patients (aged 1.25-70 years) were compared with those from 300 patients undergoing unilateral PCNL in separate sessions. At one centre where extracorporeal shockwave lithotripsy (ESWL) was available SBPCNL was used for stones where at least two sessions of ESWL would have been required on each side. Other associated procedures were also used wherever required. RESULTS: The stones were cleared bilaterally in one session of SBPCNL in 190 patients; in eight, fragments of < 3 mm remained but were not clinically significant. A second session was required in six patients on one side only. Variables assessed before and after treatment (e.g. hospital stay, analgesia requirements and complications) were not significantly different between SBPCNL and PCNL. The mean (range) total operative duration for SBPCNL was 46 (20-100) min and the hospital stay 4.3 (3-8) days. CONCLUSION: From this experience, SBPCNL is a cost-effective and beneficial solution for selected patients, with clear advantages over separate unilateral PCNL in patients with bilateral stones.

Adolescent↗
PubMed2001

Femtosecond Structural Dynamics in VO2 during an Ultrafast Solid-Solid Phase Transition.

Femtosecond x-ray and visible pulses were used to probe structural and electronic dynamics during an optically driven, solid-solid phase transition in VO(2). For high interband electronic excitation (approximately 5 x 10(21) cm(-3)), a subpicosecond transformation into the high-T, rutile phase of the material is observed, simultaneous with an insulator-to-metal transition. The fast time scale observed suggests that, in this regime, the structural transition may not be thermally initiated.

Journal Article↗
PubMed2001

[Prinzmetal angina pectoris associated with 3rd degree atrioventricular block].

The authors report on the case of a 61 year-old female patient who was repeatedly taken to hospital because of chest pain and temporary loss of consciousness. During her hospitalization there was no ST elevation on the ECG, sinus bradycardia, other times atrial fibrillation was detected. The diagnosis was made by Holter monitoring three years after the onset of complaints. At this time chest pain set in after midnight, which was followed by loss of consciousness. Significant ST elevation and IIIrd degree AV block were detected. The coronarography showed non-significant coronary stenosis. According to the vasospastic patomechanism nitrate, calcium antagonist and acetylsalicylic acid therapy was administered and because of the complete AV block leading to syncope a VVI, M pacemaker was implanted. During the two years passed since the implantation of the pacemaker the patient had chest pain only once and it was not accompanied by syncope.

Adams-Stokes Syndrome↗
PubMed2001

Percutaneous suprapubic cystolithotripsy for pediatric bladder stones in a developing country.

OBJECTIVE: To evaluate our experience with percutaneous suprapubic cystolithotripsy (PCCL) in Yemeni children with endemic urinary bladder stones. PATIENTS AND METHODS: Between January 1993 and December 1998, 117 children underwent percutaneous suprapubic lithotripsy in Arabia Felix Modern Hospital, Sana'a Republic of Yemen. The patients' ages ranged from 8 months to 14 years (average 3.7 years). Ninety patients (77%) were under 5 years old; 20 patients (16%) were between 6 and 10 years old, and 7 patients (6%) were between 11 and 14 years old. There were 116 boys and 1 girl. The stone size ranged from 0.7 to 4 (average 2.3) cm. Five patients had coexisting urinary bilharziasis and another 5 patients had coexisting renal stone. In 10 patients, the stone was in the urethra. The procedure was done under general anesthesia. Dilation of the tract was made under fluoroscopy. The instrument was an adult 26-french nephroscope, the same as that used for percutaneous nephrolithotripsy. Ultrasound disintegration was needed for stones of > 1 cm. A suprapubic catheter was left for 24 h, and a urethral catheter was kept for 48 h. RESULTS: All patients became stone free. The average operating time was 15 (5-50) min. The average hospital stay was 2.7 (2-5) days. No severe intra- or postoperative complication was observed. The nucleus and/or the main component of the stones were ammonium acid urate in 109 patients (93%). CONCLUSION: Based on our experience we can conclude that percutaneous suprapubic lithotripsy is a safe and effective method for the treatment of bladder stones in children. It reduces morbidity and hospital stay and thus the cost of treatment. Our series proves the nutritional etiology of endemic pediatric bladder stones. To our knowledge, this is the largest series reported on percutaneous suprapubic management of endemic bladder stones in children.

Adolescent↗
PubMed2001

[Evolution and change of strategy in carotid artery surgery in Debrecen].

In the 1st Department of Surgery, in Debrecen, operations on supraaortic arteries are done, since 1985. In the first five years, sporadically, only 2-3 carotid reconstruction have been done. Between 1990-1996 the number of these operations were about 20 per year, although the number of postoperative complications were around 1%. The number of operative interventions on the carotid region were doubled in 1997 and from 1999 were four times more. The authors analysed the data of the patients, accumulated in the last 6 years. In this period 258 operations were done. Unilateral significant stenosis found in 159 (61%) patients and bilateral serious stenosis or unilateral occlusion in 99 (38.6%) patients. 22.4% of the patients who were operated in our department, were waiting for coronary revascularisational operation because of angina pectoris. 5.4% suffered from vitium and were later undergone cardiac valve operation. By 24% of the patients later, electively we performed reconstructional vascular operation on the lower limbs. The base of preoperative examinations was cerebrovascular circulational insufficiency by almost half of the patients (46.1%). Beside anaesthesiological basic examinations, detailed diagnostics (exercised EKG, TTE, coronariography, Holter monitor) were done. In the overwhelming majority of the operations we used the eversion technique. The surgical interventions were performed in every case using non-invasive haemodynamical monitor (transoesophageal doppler ODM-II). Our results meet the requirement of the national and international standouts. These results prove, that with the help of comprehensive pre-operational examinations and preparation, intraoperative monitor and having up-to-date, precise operational technique, the international standards can be sustained even treating patients with such a high risk.

Adult↗
PubMed2001

[Rare case of popliteal artery injury caused by distal femoral exostosis. Case report].

Complications of multiple exostoses occur rarely and articles about it can be found occasionally. We found reasonable to report our case because of its rarity. A female patient of 17 was under treatment in the Orthopaedic Clinic with multiple exostoses. Before her admission to the Clinic, a suddenly, painful swelling in the distal-third of the left femur occurred, and then a well detailed examination has done (bone radiograph, angiogramm, MR). The examinations arised the presence of pseudoaneurysm as a background of the swelling of the soft tissue, as well as the possibility of juvenile bone tumor at the same time. During the operation we detected a sharp exostosis on the distal medial condyle of the femur, which occurred a lesion on the popliteal artery. It was the base of forming the pseudoaneurysm. As a conclusion we would like to underline that during the attend of such cases, the presence of vascular surgical team is necessary.

Adolescent↗
PubMed2000

Anharmonic lattice dynamics in germanium measured with ultrafast x-ray diffraction.

Damping of impulsively generated coherent acoustic oscillations in a femtosecond laser-heated thin germanium film is measured as a function of fluence by means of ultrafast x-ray diffraction. By simultaneously measuring picosecond strain dynamics in the film and in the unexcited silicon substrate, we separate anharmonic damping from acoustic transmission through the buried interface. The measured damping rate and its dependence on the calculated temperature of the thermal bath is consistent with estimated four-body, elastic dephasing times (T2) for 7-GHz longitudinal acoustic phonons in germanium.

Journal Article↗
PubMed2000

Percutaneous nephropexy.

OBJECTIVE: The authors present a 12-year (1986-98) study of a new procedure called percutaneous nephropexy (PCNP). This procedure was performed on 51 renal ptosis patients at two urological departments (in Pakistan and Hungary) with satisfactory results. The idea for PCNP was adapted from the observation that after drain insertion following nephrostomy a scar is quite sufficient to hold the kidney in place. That idea was used to fix the kidney at the required level. MATERIAL AND METHODS: Thirteen patients complained of a palpable mobile mass in the abdomen while others suffered from pain in their affected flank with recurrent attacks of urinary tract infection. On ultrasonic examination the kidney was found to be lower than the normal position. This observation was confirmed by a standing intravenous urography (IVU) examination that also showed a tortuous ureter. Nine patients also had a stone in the affected kidney. The operation involved puncture and dilatation of a channel through the lower calyx. RESULTS: Control IVU examination was performed after wound healing and was repeated 2 months after the operation, followed by consecutive ultrasonic examinations. Standing X-ray films obtained after contrast material injection showed the kidney to be at a higher level with a straight ureter. Forty-five patients (88.2%) recovered completely. CONCLUSION: In the authors' opinion PCNP is a good alternative to open nephropexy operations in renal ptosis cases, particularly when laparoscopic surgery facilities are not available. Although PCNP was developed in circumstances in which the availability of equipment was restricted, in terms of benefits it is comparable with laparoscopic nephropexy.

Adolescent↗
PubMed1999

Detection of nonthermal melting by ultrafast X-ray diffraction.

Using ultrafast, time-resolved, 1.54 angstrom x-ray diffraction, thermal and ultrafast nonthermal melting of germanium, involving passage through nonequilibrium extreme states of matter, was observed. Such ultrafast, optical-pump, x-ray diffraction probe measurements provide a way to study many other transient processes in physics, chemistry, and biology, including direct observation of the atomic motion by which many solid-state processes and chemical and biochemical reactions take place.

Biochemistry↗
PubMed1999

Evaluation of the AnaeroPack Campylo system for growth of microaerophilic bacteria.

Growth of microaerophilic bacteria in the AnaeroPack Campylo (Mitsubishi Gas Chemical America, Inc., New York, N.Y.) atmosphere generation system was compared to growth in the CampyPak Plus jar and CampyPak pouch (Becton-Dickinson Microbiology Systems [BDMS], Cockeysville, Md.). Growth in the AnaeroPack Campylo system was considered equivalent to or better than growth obtained in the CampyPak Plus and CampyPak pouch systems for 48 of the 50 Helicobacter pylori strains and for all 28 Campylobacter species tested. All of the 78 organisms tested were recovered in each system in equivalent colony counts. Two strains of H. pylori grown in the AnaeroPack Campylo system were observed to have colony morphology growth discrepancies when compared to growth in the two BDMS systems. Atmosphere failure with the AnaeroPack Campylo was not detected with Campylobacter jejuni ATCC 33291 used as a growth control. The AnaeroPack Campylo system is easy to use and supports the growth of campylobacters and H. pylori.

Anaerobiosis↗
PubMed1998

Laparoscopically assisted percutaneous transperitoneal nephrolithotomy in pelvic dystopic kidneys: experience in 15 successful cases.

The stone-holding pelvic dystopic kidneys of 15 patients were treated with laparoscopically assisted percutaneous transperitoneal nephrolithotomy. With patients in the Trendelenburg position under laparoscopic control, the bowels were dislodged with forceps until the kidney became visible. Under simultaneous laparoscopic and fluoroscopic control, the nephrostomy track was created on the antegrade route using telescopic metal dilators and a rigid nephroscope. Percutaneous nephrolithotomy was carried out in the usual manner. All the stones could be removed successfully. The only minor complication was a delayed urine leakage through the abdominal drain in a patient with a double J stent. Severe complications did not occur. The average operating time was 55 (40-85) minutes; the average hospital stay was 4.8 (4-11) days. On the basis of the authors' experience and a literature review of cases of failed shock wave lithotripsy-which is quite frequently unsuccessful in these cases-and cases of large, dense stones, this method appears to be the simplest and most suitable minimally invasive treatment of the stone-holding pelvic dystopic kidney.

Adolescent↗
PubMed1997

[Significance of early echocardiography in acute myocardial infarct].

The authors examined the role of echocardiography performed in the acute phase of the myocardial infarction, within 72 hours after hospitalization in order to reveal the diagnosis, to detect of the complications and mortality in hospital. 512 consecutive patients were examined by echocardiography. All of them were younger than 70, and they were treated at our department between 1st January, 1991 and 31st December, 1994 with acute myocardial infarction. In 34 cases the infarction was without Q wave. The most severe left ventricular wall motion abnormality was dyskinesis in 53, akinesis in 390, hypokinesis in 49 cases, normokinesis was detected in 20 patients. The detection of the wall motion abnormality helped to diagnose 27 right ventricular infarctions, 58 reinfarctions and 21 acute myocardial infarction with left bundle branch block. 43 patients (8.4%) died during the treatment. In all cases the pathological examination verified the diagnosis of the acute myocardial infarction, and at 4 patients free wall rupture had been revealed. Among the deceased left ventricular dilatation (16/43 versus 75/469, p < 0.001), ejection fraction lower than 40% (14/43 versus 52/469, p < 0.001), left ventricular wall motion abnormality index (16 segments; 1 = normokinesis, 2 = hypokinesis, 3 = akinesis, 4 = dyskinesis, 5 = aneurysm) higher than 2.0 (27/43 versus 93/469, p < 0.001), dyskinesis (12/43 versus 41/469, p < 0.001), pericardial effusion thicker than 5 mm (7/43 versus 31/469, p < 0.05), and right ventricular infarction (6/43 versus 21/469, p < 0.05) occurred significantly more often. Dyskinesis is a bad prognostic factor even in the case of good left ventricular function. According to the opinion of the authors, echocardiography performed at the early stage of acute myocardial infarction, increases the safety of the diagnosis and calls the attention to the patients with high risk.

Acute Disease↗
PubMed1997

Endopyelotomy: experience with 320 cases.

We were the first to initiate endopyelotomy in Hungary (in 1986) and in Yemen and Pakistan (in 1993). Through the end of 1995, 320 cases of ureteropelvic junction (UPJ) stenosis have been operated upon. The procedure was performed under local anesthesia in adult patients and general anesthesia in children. The minimum age of the patient was 4 years, while the oldest patient was 80 years of age. The UPJ was incised longitudinally at the posterolateral aspect until the perinephric fat was seen, and a drain of 8F to 12F was inserted transrenally into the ureter through a nephroscope. Patients soon left the hospital and were able to start working in 5 days (average). The drain was removed after 6 weeks. During the follow-up period, ultrasonic examination was performed each 3 months. The success rate (mean of three centers) came out to be 87%. Open pyeloplasty was performed in cases where the symptoms of pyelectasia were persisting and caused complaints and stenosis was present even after 6 months. In our opinion, endopyelotomy should be the procedure of first choice for UPJ stenosis, because it is less troublesome for the patient than open pyeloplasty, and the results are real encouraging.

Adolescent↗
PubMed1995

[The role of laparoscopy in the management of prostatic cancer].

Laparoscopic lymphadenectomy is a new surgical modality with increasing usage in the staging and management of prostate carcinoma. Since the presence or absence of metastatic disease in the pelvic lymph nodes must be assessed for proper treatment planning, and preoperative staging studies have a high rate of false negative results, histological evaluation of the pelvic lymph nodes should be performed prior to radical prostatectomy. Laparoscopic pelvic lymphadenectomy is a well tolerated, safe, and accurate alternative to the conventional open surgical procedure.

Humans↗