The authors studied the pathomorphy of 364 cases of chronic thyroiditis including Hashimoto's thyroiditis (67 cases), Hashimoto's thyroiditis associated with thyroid cancer (21 cases), De Quervain's thyroiditis (10 cases), tuberculous thyroiditis (6 cases), and 260 cases of focal thyroiditis without manifest clinical symptoms appearing in 10% of euthyroid polynodular goitres. A personal classification of chronic thyroiditis is presented. The high incidence (24%) of association between thyroid cancer and the fibrous type of Hashimoto's thyroiditis is emphasized. A morphometric investigation showed the highest sclerosis percentage in De Quervalin's thyroiditis.

Adolescent↗

PubMedDate not supplied

Histopathology of some carcinomatous and pseudocarcinomatous aspects of the thyroid.

The authors studied the histopathology of some true carcinomatous and pseudocarcinomatous aspects of the thyroid. Some peculiar aspects occuring after therapy with thyreostatics are underlined: papillary structures, giant polymorphous, hyperchromic or light vesicular nuclei. These lesions are not to be confused with true neoplastic pictures. The criteria in discriminating between thyroid adenoma and follicular adenocarcinoma are also discussed.

Adenocarcinoma↗

PubMedDate not supplied

Scanning electron microscopy of euthyroid goiter and Graves's disease.

The scanning electron microscopy of 5 euthyroid polynodular goiters and 5 cases of Grave's disease was studied. In the polynodular goiter most of the follicular cells were flattened. Small, coarse, irregular microvilli were noticed. In the Grave's disease cases the follicular cells were columnar, covered with long microvilli. Marked epithelial infoldings were found. Thick bundles of collagen surrounded the follicles, especially in the polynodular goiter.

Adult↗

PubMedDate not supplied

Histopathology of thyroid carcinoma. A review of 500 cases.

A lot of 500 thyroid cancers were studied. The following histological aspects were found: folliculo-papillary carcinoma (60.6%), follicular carcinoma (20.6%), anaplastic carcinoma (15,4%), medullary carcinoma (3.2%), malignant lymphoma (0.2%). The sex distribution showed a strong predominance of women as compared to men, in a ratio of 3/1. The highest incidence appeared between 30 and 50 years of age. The histopathological and cytological features in fine needle biopsy are discussed.

Adenocarcinoma↗

PubMedDate not supplied

Ischemic lesions of hepatocytes and sinusoidal cells during preservation of rat liver for transplantation.

In order to evaluate the effects of cold and normothermic preservation on liver morphology, rat livers were placed in Collins' and NaCl 0.9% solutions at 4 degrees C and 25 degrees C, for 3.12 and 24 hours. Hepatocytes morphology was remarkably well conserved during cold preservation; in normothermy, only after 24 hours we noted hepatocytes swelling and karyorhexis. On the contrary, sinusoidal cells lesions were earlier (at 3 hours) and became irreversible after 12 hours of cold preservation. The signs of irreversibility (sinusoidal cells detached from the adjacent hepatocytes, pyknotic nuclei and karyolysis) were observed at an earlier stage than in normothermic conditions and during preservation in NaCl 0.9%. The mean diameter of hepatocytar nucleus and the mean hepatocytar diameter were modified, compared with the control livers, only after 24 hours of preservation in Collins' solution. Mean sinusoidal area alone was modified at 12 hours of cold preservation in Collins' solution (9.80% versus 12.10% in controls). Both histological changes and morphometric data sustained the idea that in liver preservation, sinusoidal cell lesions appeared earlier than the hepatocytes lesions. In evaluating the reversibility of the ischemic damage, attention should be focussed on the events in the sinusoidal wall.

Animals↗

PubMedDate not supplied

Acute experimental pancreatitis--morphological evidence for the development of a multiple organ failure syndrome.

In order to evaluate the systemic lesions during acute pancreatitis (AP) we produced the disease in rats by ligation of the common biliopancreatic duct. The animals were killed at 4, 24, 48 hours and at 7 days. Serum values of amylase appear increased 24 hours after common biliopancreatic duct ligation, decreased after 48 hours and remain at a low range at 7 days. The pancreatic lesions were: interstitial oedema, pancreatic ducts dilatation, necrosis, hemorrhages and extensive fat necroses in the peripancreatic area, retroperitoneum and mesentery. We also found signs of systemic damage, suggestive for a multiple organ failure syndrome in the lung (hemorrhages, neutrophils accumulation, microthromboses), stomach (erosive and hemorrhagic gastritis) and mild kidney hemorrhages. Thus we succeed in producing a pathological picture similar to the multiple organ failure syndrome (MOFS) lesions in a rat model by a mechanism similar to human biliary AP. This model could be useful in therapeutic studies and in further research in the field of pathogenesis of MOFS during AP.

Acute Disease↗

PubMedDate not supplied

Urothelial bladder biopsy--important evolution prognosis factor of superficial bladder cancer under intravesical Bacille Calmette-Guérin therapy.

During 11 years we investigated the value of multiple randomised biopsies (4 quadrant) and by in vivo staining with methylene blue (chromocystoscopy) of 231 cases with superficial bladder tumours under complementary intravesical Bacille Calmette-Guérin therapy (3 years of immunotherapic treatment after our protocol). We discovered the appearance of 20 cases with carcinoma insitu (Cis) and 105 cases with different degrees of dysplasia (simple, medium and severe). We demonstrated 69.44% pathological bladder biopsies on normal-looking mucosa. 75% of the recurrent tumours (44 cases-22.44%) had pathological bladder urothel al field modifications associated with bladder cancer. On this occasion, we point out the highest prognostic value of the complex protocol of superficial bladder tumour evaluation based on the study of the bladder biopsies as an essential parameter.

BCG Vaccine↗

PubMedDate not supplied

Evolution of carcinoma in situ under intravesical Romanian Bacille Calmette-Guérin therapy.

We analysed the evolution of 33 cases with carcinoma in situ (Cis) of the urinary bladder using the intravesical Bacille Calmette-Guérin (BCG) therapy (2 cases with primary Cis, 20 cases discovered at 4 quadrant biopsies within surgical treatment of superficial bladder tumours and 5 cases discovered at 3 monthly evaluation cystoscopy and chromocystoscopy). The mean period of follow-up was 40 months. Our protocol of immunotherapy was maintained for 3 years (8 weekly instillations with 100 mg Romanian--modified Pasteur BCG vaccine in 50 ml of saline, followed by monthly instillations for 10 months and then 3 monthly instillations for 2 years with the same doses). We described the great importance of this "long-course treatment": 12 cases with persistent Cis after 6 months and 2 cases with persistent Cis after 21 months. During September 1984-August 1990 we registered 6 invasive tumours (18.18%). These results showed the dynamic evolution of Cis under long-term intravesical immune BCG stimulation.

BCG Vaccine↗