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Biomedical subjects

C Tapia

Publications and source records attributed to C Tapia.

4 recordsLinked to original sources
PubMed1991

Behavioral effects of intracerebral administration of luteinizing hormone releasing hormone (LHRH) in rats.

The effects of LHRH intracerebrally infused on acquisition of conditioned avoidance responses (CARs) and spontaneous motility were studied in adult male rats. The results were the following: 1) LHRH (1 and 2.5 micrograms/rat) administered through a cannula stereotaxically implanted into the lateral ventricle induced an impairment in the acquisition of CARs along with an increase in global motility, rearing, head shaking and grooming behavior; 2) LHRH 1 microgram/rat injected into the hippocampus or nucleus accumbens induced also an impairment in acquisition which is evident 15 min after treatment. In contrast, intrastriatal injection induced an immediate disruption of this behavior; and 3) there is a good dose-response relationship for intrastriatal LHRH between 7.8 and 62.5 ng/rat. The results suggest that the estriatum could be the locus of the LHRH-induced inhibition of CARs. Then the possibility of an involvement of the dopamine nigrostriatal system is discussed.

Animals↗
PubMedDate not supplied

Month at menarche: a re-evaluation of the seasonal hypothesis.

The hypothesis of a dominant or major seasonal factor that produces the winter peak of menarche found in European girls was tested using several Caucasian and Mongolian samples from the northern hemisphere and two Chilean samples. Present results do not support such a hypothesis. The month at menarche of Chilean girls did not show the expected winter peak; February, a winter month in Europe, showed a deep trough in most samples. Instead, several Mongolian and Caucasian samples from the northern hemisphere clustered according to their ethnic origin rather than to the expected northern hemisphere yearly distribution of photoperiods and temperatures. Other non-seasonal factors seem to explain much better the periodicity of the monthly incidence of menarche. A phylogenetic factor (imprinting) is proposed to explain peaks seen in December and January for Caucasian, Mongolian, Finnish and Chilean samples living in the northern and southern hemispheres. Ontogenetic factors are proposed to explain the highly significant coincidence between the month of menarche and the month of birth, and the modulation of the phylogenetic imprinting by months at which gestation occurred in relation to menarche. The Finnish and Chilean samples, which can be considered mixed Caucasian and Mongolian, showed an intermediate pattern between the Caucasian and Mongolian groups.

Adolescent↗