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Biomedical subjects

C Terrence

Publications and source records attributed to C Terrence.

5 recordsLinked to original sources
PubMed1985

Baclofen versus diazepam for the treatment of spasticity and long-term follow-up of baclofen therapy.

Baclofen (25 to 60 mg per day) and diazepam (10 to 40 mg per day) were evaluated for spasticity reduction in a double-blind, crossover study in 13 patients over a period of 19 weeks. Both drugs produced overall improvement and there was no significant difference in preference for one or other treatment. Side-effects, especially excessive daytime sedation, were more common in the diazepam group. In a companion baclofen long-term study, 18 spastic patients were treated with baclofen for an average of 4 years. Baclofen discontinuation in this group resulted in a worsening of spastic signs and symptoms in 16 patients, with no evidence of drug tolerance even after many years of baclofen therapy.

Adult↗
PubMed1979

Computerized tomography in hereditary nonprogressive chorea.

A 56-year-old woman had a 50-year history of childhood-onset chorea without progressive neurologic deficit. The patient's father had a lifelong extrapyramidal disorder characterized by a head-nodding tremor and involuntary movements especially evident with anxiety. The computerized tomographic scan was normal, without evidence of cortical or caudate atrophy. The computerized tomographic scan supports the notion of a functional rather than a structural lesion, and may aid in the discrimination of hereditary nonprogressive chorea from more devastating forms of hereditary chorea.

Adolescent↗
PubMed1979

An unusual case of paroxysmal facial pain.

Paroxysmal facial pain is a rare sequel to brainstem infarction. This is a report of a patient who developed paroxysmal facial pain with the exceptional features of a trigger zone and relative refractory pain-free periods in an area previously anesthetic after infarction of the brainstem. The characteristic of this patient's pain is compared with the pain is compared with the pain of trigeminal neuralgia and possible similar pathogenetic mechanisms.

Brain Stem↗
PubMed1978

Phenytoin dosage in ambulant epileptic patients.

Ambulant patients with recently diagnosed generalised or psychomotor seizure disorders or both were randomly assigned to two dosage regimens of phenytoin. Drug compliance was evaluated with subsequent blood phenytoin levels four to eight weeks after initial enrollment into the study. Although the two groups had similar mg-kg daily dosages of phenytoin, the mean blood levels were statistically different between the two groups, favoring the simplified dosage regimen. Once or twice a day dosage regimens of phenytoin had a beneficial effect on drug compliance when compared to more frequent regimens as measured by phenytoin blood levels.

Drug Therapy, Combination↗