PubMed Health⌕ Search

Biomedical subjects

C Thurel

Publications and source records attributed to C Thurel.

16 recordsLinked to original sources
PubMed1992

Cerebral vasodilation after the thermocoagulation of the trigeminal ganglion in humans.

The resulting changes in the regional cerebral blood flow of 18 patients suffering from idiopathic trigeminal neuralgia and treated by selective thermocoagulation of the trigeminal ganglion were measured by xenon-133 emission tomography. One hour after thermal stimulation, there was an asymmetric increase (P < 0.05) in cerebral blood flow, with a 14.7% mean increase in the ipsilateral cerebral hemisphere (P < 0.001) and a 12.7% mean increase in the contralateral side (P < 0.01). The increase in regional cerebral blood flow was not uniform but was most marked in the ipsilateral middle cerebral artery territory (P < 0.001). There was a slight decrease in cerebellar blood flow, but the reduction in the ipsilateral cerebellar lobe was less than that in the contralateral lobe (P < 0.01). The topography of the most significant changes coincided with that of the innervation of the cerebral vessels by the trigeminal nerve. Several mechanisms are involved in the increase in regional cerebral blood flow, including overall nonspecific activation of the central nervous system and local mechanisms associated with the trigeminal-vascular system.

Adult↗
PubMed1991

Levels of morphine and metabolites in CSF during respiratory depression after intraventricular morphine injection.

We report a case of respiratory depression after intracerebroventricular morphine administration of a dose inadvertently 10 times greater than the typical daily dose. At the time of the respiratory dysfunction, the concentrations of morphine and its metabolites in cerebrospinal fluid (CSF) and plasma samples were determined. On comparison of these results with previous clinical studies in which there was no respiratory depression, no relationship was found between the occurrence of respiratory depression and the concentration of morphine or its metabolites in the CSF. The occurrence and characteristics of respiratory depression may be related to the concentrations of morphine and its metabolites in bulbar tissue.

Adenocarcinoma↗
PubMed1979

Relevance of antibiotics in the treatment of brain abscesses. Report of a case with eight simultaneous brain abscesses treated and cured medically.

A case of eight simultaneous brain abscesses in the right cerebral hemisphere, treated medically after puncture of two of them, is reported. Antibiotics and hypertonic mannitol and, after seven days, dexamethasone were sufficient to cure these lesions. CT scan was of primary importance to follow the evolution under treatment. To get the best efficiency from antibiotics, identification of the microorganism and assessment of its resistance to antibiotics are necessary. It is suggested that in certain conditions medical therapy might be sufficient to treat cerebral abscess, after simple puncture to isolate the infecting agent. Corticosteroids should be avoided in the acute phase because they prevent antibiotics from penetrating the abscesses.

Adult↗
PubMed1978

[Current data on pain pathways].

1--The classical notion attributing the conduction of painful messages to only the A delta and C fibres will be discussed. 2--Spinal cord cells of layers I, V and VIII received painful messages and their physiological properties will be compared. 3--The origin within the cell layers of the spinal cord of the various ascending bundles will be examined. 4--The reticular an thalamic zones (posterior ventra nucleus, mid-line and intralaminar nuclei, GMme posterior group in particular) which receive painful messages have also been studied using activation provoked by pinching, pinprick, the injection of painful substances and stimulation of the dental pulp. The possible role of the different structures thereby brought into action and the limitation of these techniques will be discussed. 5--The existence of metameric controls and controls of central origin active at a spinal, reticular and thalamic level. The absence of inhibitory controls may be responsible for the development of abnormal painful sensations which accompany certain deafferentation procedures. The reestablishment of these controls with the aid of stimulation may result and often results in the improvement of these painful syndromes. 6--Section of the dorsal routes in the chronic animal (rat and cat) may represent an experimental model for deafferentation pain seen in man.

Animals↗
PubMed1978

[Investigation of the immunity status towards tetanus of a population of mechanics at the car-factory "Renault" (author's transl)].

Tetanus immunity has been studied in a population of mechanics working at the car-factory "Renault". For the study, 283 individuals were divided into 3 groups. The first group consisted of non-vaccined individuals, the second of vaccinated individuals and the third of individuals who had been boostered. The influence of different parameters on tetanus immunity status was considered, i. e. the age of the subjects, the time at which boostering was given, the serotherapy (when it was administered) and the contact with machine lubricating and cooling fluids. Clostridium tetani bacilli and spores were frequently found in aqueous machine fluids. Their presence is a potential hazard for non-vaccinated mechanics coming to contact with the fluids. Tetanus antibody levels in the sera of the tested population were determined in vivo by the toxin neutralization test. The influence on tetanus immunity of the different parameters considered in this paper was subjected to statistical analysis. From the whole population, 27% of the individuals were found to have no protection against tetanus. When age was taken into account, 53% of the individuals over 45 years old and 10% of those under 45 years old were shown to be devoid of tetanus immunity. It could be shown that younger individuals were better protected than older ones, because the formers had been immunized with adsorbed tetanus toxoid and most of the latters with fluid toxoid. Of the individuals in the third group who had received a booster injection within 15 years after primo-vaccination, 98% showed protective tetanus antibody levels in their sera in contrast to 25% when boostering had occurred more than 15 years after primo-vaccination. Contact with machine fluids was found to influence the degree of immunity of only those individuals whose boostering dated back to more than 25 years. Unexpectedly, 3 mechanics seemed to develop immunity after coming into contact with machine fluids. From the results reported here, it is concluded that tetanus immunity in vaccinated individuals should be renewed by a compulsory booster injection given every 5, 10 or, at the minimum, 15 years. Moreover, high-risk populations such as that represented by the mechanics should be immunized or boostered on commencing employment.

Adult↗
PubMed1977

[Lumbar phlebography. Normal aspect and its value in diagnosis of herniated disk].

Our technique of lumbar phlebography involves selective catheterisation of the lateral sacral veins with or without catheterisation of the ascending lumbar veins. Injection of these veins, in association with abdominal compression, produces good filling of the intra-spinal epidural veins, particularly at L5-S1 level. The anatomy and radiological appearances of the epidural veins are discussed. The phlebographic signs of disc herniation are presented. The diagnostic potential of this technique seems very promising in disc pathology, especially in the diagnosis of L5-S1 herniation and lateral prolapse at all levels.

Back Pain↗
PubMed1977

[Treatment of essential facial neuralgia by selective thermocoagulation of Gasser's ganglion].

The authors report their experience in the treatment of essential facial neuralgia by differential thermocoagulation of the gasserian ganglion. This method is based upon the fact that small pain fibres (A delta and C) are more sensitive to warmth than large touch fibres. Thus progressive and controlled thermocoagulation of the trigeminal ganglion makes it possible to obtain selective destruction of the small fibres (analgesia without anaesthesia). 76 patients were treated using the method, and in 75 cases the symptoms of neuralgia disappeared immediately. Mortality is nil and morbidity insignificant other than the effects on the trigeminal nerve. The most serious complication (Approximately 10% of cases) was that of marked hypoaesthesia, rather than pure analgesia, in the coagulated area.

Adult↗
PubMed1975

[External temporal biopsy in a case of infiltrating limbic glioma: study of astrocytic membranous wrapping whorls (author's transl)].

An intracranial hypertension was found at autopsy to be due to a limbic infiltrating glioma. A cortical temporal biopsy had been done 14 months before, whose ultrastructural results are reported. Membranous whorls, made of two dense membranes with a variable separative space are seen around neurones, dendrites, axons, synapses and oligoglial cells; they derived from astrocytes and are joined by 2 types of cell junctions: gap-junctions and puncta adherentia. Relations between reactive and tumoral gliosis are discussed.

Adult↗
PubMedDate not supplied

[Arteriography in pituitary tumors. Pseudotumoral aneurysm].

In the presence of any "expansive process" of the sellar region, one must recall that in I % of the instances there may be the possibility of a pseudo-tumoral aneurysm. In a number of cases, neither the clinical study, nor the roentgenologic and tomographic balance of the sellar region, will allow to differentiate an aneurysm and a pituitary tumor. Only the carotid arteriography makes possible a diagnosis of certainty under the condition to make a bilateral study (compression being insufficient). This kind of investigation will therefore be systematic, particularly in those cases in which a sphenoid route of access is considered for the management of the expansive process of the sellar region.

Carotid Arteries↗
PubMedDate not supplied

[Treatment of primitive trigeminal neuralgia by differential thermocoagulation of Gasser's ganglion (author's transl)].

The authors report their experience in the Treatment of essential Trigeminal Neuralgia with controlled increments of radiofrequency heating from an electrode inserted in the Gasserian ganglion or the posterior rootlets. Assuming that the less myelinated small fibers (A delta and C) are more sensitive to the heat than the heavily myelinated A beta and A alpha fibers, graduate controlled thermo coagulation could produce a differential destruction of pain fibers. 30 patients were treated with this method since 10 months. In all cases, the patients experienced immediate relief. There was no mortality and no neurological morbidity outside the trigeminal nerve. The most serious undesired result has been the production of anesthesia or marked hypesthesia in 10% of our cases.

Electric Stimulation↗