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Biomedical subjects

C Tomlinson

Publications and source records attributed to C Tomlinson.

13 recordsLinked to original sources

Sandor Rado and Adolf Meyer: a nodal point in American psychiatry and psychoanalysis.

Previously uncited archival material, principally letters between Adolf Meyer and Sandor Rado, is used to document the importance of a relationship between two influential figures in american psychiatry and psychoanalysis at a fateful moment in the evolution of both. Although Meyer and Rado have each fallen into relative neglect, their interaction not only was a crucial part of the schisms in American analysis in the 1930s and 1940s, but represented an important juncture in the history of the relationship between medicine, academic psychiatry and psychoanalysis in North America. Meyer's powerful influence was thus an essential component of Rado's attempts to rewrite psychoanalytic theory and terminology wholesale. Moreover, Rado specifically integrated the results of a radically integrationist agenda he had consolidated in his contact with Meyer into the organisation and educational programme of the psychoanalytic institute he founded at Columbia University in the early 1940s.

History, 19th Century

Haemodialysis recirculation detected by the three-sample method is an artefact.

The efficiency of haemodialysis may be limited by recirculation of blood between venous and arterial needles. Recirculation can be detected directly using a saline dilution method but is most commonly calculated from the urea concentrations of simultaneous samples from venous and arterial lines and a peripheral vein (three-sample method). The methods detect markedly different rates of recirculation in similar study populations. To investigate the possibility that the methods detect different phenomena, we performed both tests on 16 haemodialysis patients at various extracorporeal blood flow rates (Qb). The saline dilution method showed no recirculation in any of the patients, whereas the three-sample method indicated recirculation in all patients. The three-sample method indicated a mean recirculation fraction of 12.5% (SD 6.1) and was not influenced by changing Qb, suggesting that it was not detecting fistula recirculation. The three-sample method detects a solute concentration difference between arterial blood and peripheral blood during dialysis. There appears to be a disequilibrium between a central pool, represented by the arterial sample, and a poorly perfused peripheral pool, relatively isolated from the dialysis process, represented by the peripheral venous sample. The three-sample method for detecting recirculation should be abandoned.

Arteries

G. C. Lichtenberg: dreams, jokes, and the unconscious in eighteenth-century Germany.

The German physicist and writer Lichtenberg (1742-1799) was well known during the nineteenth century as a humorist, thinker, and psychologist. He was also a favorite author of Freud, who read him beginning in his teens, quoted him frequently, and called him a "remarkable psychologist." Despite this, he has been ignored by psychoanalysts and historians of psychiatry alike, and most of his writing is still unavailable in English. An introduction to Lichtenberg as a psychologist is provided, stressing material dealing with dream analysis, association theory, and drives. Relevant excerpts are translated into English. Lichtenberg is shown to have insisted upon the need for a systematic and rationalistic study of dreams, to have analyzed individual dreams (describing them as dramatized representations of thoughts, associations, and even conflicts from his own waking life), and to have emphasized the functional link between dreams and daydreams. His remarks on drives and commentary on eighteenth-century association theory represent a significant practical application, and thus refinement, of Enlightenment rationalistic psychology. These achievements are assessed in light of Freud's early fascination with him; it is argued that Lichtenberg is an example of the relevance of the historical and cultural background of psychoanalysis to clinical practice.

Association

Papillary cancer in a patient treated with radioiodine for Graves' hyperthyroidism. Case report and a review of the risk.

A small encapsulated papillary thyroid cancer was found in a patient who had received I-131 therapy for Graves' disease 31 months previously. The relationship of Graves' hyperthyroidism and thyroid cancer is discussed, as well as the possible role of I-131 as a cause of the cancer. The published data do not support I-131 as an etiology. The patient is clinically well and cured of both hyperthyroidism and the cancer.

Adult

Canadian consensus recommendations for the measurement and reporting of diastolic dysfunction by echocardiography: from the Investigators of Consensus on Diastolic Dysfunction by Echocardiography.

Abnormalities of diastolic filling are increasingly recognized as a cause of symptoms and predictors of outcome in patients with most forms of heart disease. Noninvasive assessment of diastolic filling is possible in almost all patients, but accurate evaluation must relate echocardiographic Doppler measurements to the complex physiologic and hemodynamic factors responsible for normal and abnormal filling. This evaluation has been facilitated by recent correlation of Doppler measurement of mitral and pulmonary venous inflow with hemodynamic studies. These studies have confirmed that when a careful, integrated approach is taken, Doppler flow patterns can document a progressive pattern of abnormality in many conditions. Impaired left ventricular (LV) relaxation is seen early and is recognized by a decrease in early transmitral LV filling and an increased proportion of filling during atrial contraction. As abnormalities progress, increasing LV chamber stiffness and elevated left atrial pressure lead to a "pseudonormal" filling pattern that previously has caused considerable confusion. This can be unmasked by careful evaluation of pulmonary venous inflow and the use of the Valsalva maneuver. When marked diastolic abnormalities are present, LV filling has restrictive features characterized by rapid early filling, a very stiff left ventricle with high filling pressures, and a poor prognosis. Routine measurement of indexes of diastolic filling have been hampered by uncertainty as to what should be measured, what techniques should be used, definition of normal values, and a clear method of reporting findings. This report represents the efforts of a Canadian consensus group to define a national standard for the performance and reporting of echocardiographic Doppler studies of diastolic filling.

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