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C Touzery

Publications and source records attributed to C Touzery.

12 recordsLinked to original sources
PubMed1995

Impairment of diastolic function during short-term anthracycline chemotherapy.

OBJECTIVE: To assess the early changes in left ventricular diastolic and systolic function due to anthracycline treatment. DESIGN: A prospective study of cardiac function by radionuclide angiography in adults before and one month after the end of anthracycline treatment. PATIENTS: 60 patients without cardiac disease treated with chemotherapy containing anthracycline. METHODS: Cardiac function was assessed by radionuclide measurement throughout treatment. Ejection fraction, peak ejection rate, time to peak ejection rate, filling rate, and time to peak filling rate were measured before and after treatment. To normalise radionuclide measurements of the left ventricular diastolic function the ratio of the filling rate to the ejection fraction and the ratio of the filling rate to the peak ejection rate were calculated. RESULTS: No patient developed symptomatic congestive cardiac failure. The ejection fraction decreased from 58% (5%) to 55% (6%) (P < 0.001), the peak ejection rate fell from 2.99 (0.41) to 2.77 (0.41) of the end diastolic volume per second (P < 0.001), and the peak filling rate from 2.71 (0.47) to 2.55 (0.44) of the end diastolic volume per second (P < 0.01) after treatment. No difference was observed in the normalised ratios. CONCLUSIONS: This report shows simultaneous impairment of left ventricular systolic and diastolic radionuclide parameters. The absence of variation in normalised measurements suggests similar changes in ejection fraction, peak ejection rate, and peak filling rate throughout treatment.

Adult↗
PubMed1987

Fourier and factorial analysis: an objective and comparative evaluation on a cardiac phantom.

Orthogonal and oblique factor analysis represent an alternative to Fourier analysis in the evaluation of cardiac dynamic behaviour in gated blood pool studies. In order to estimate their respective places, orthogonal factor analysis (OFA), factor analysis of dynamic structures (FADS) and Fourier analysis (FA) are tested on a dynamic and periodical phantom with well known and reproducible kinetics. The phantom data are acquired under standard conditions by varying the counting rates and the temporal frequency sampling. To compare the results of the three methods with maximal objectivity, the relative contribution of each component is calculated. With standard acquisition conditions, FA and OFA give very close results. Only a minor advantage in evaluation of small phase differences is observed with OFA. FADS solutions are effectively related to the dynamic behaviour of the phantom, but their interpretation is more complicated and the quality of the oblique factors is reduced as the number of calculated factors increases. The influence of the counting statistics on FA, OFA and FADS is very similar. However, in cases of undersampling, robustness is demonstrated with the factorial technics.

Algorithms↗
PubMed1980

Emission computerized axial tomography from multiple gamma-camera views using frequency filtering.

Emission computerized axial tomography is achievable in any nuclear medicine department from multiple gamma camera views. Data are collected by rotating the patient in front of the camera. A simple fast algorithm is implemented, known as the convolution technique: first the projection data are Fourier transformed and then an original filter designed for optimizing resolution and noise suppression is applied; finally the inverse transform of the latter operation is back-projected. This program, which can also take into account the attenuation for single photon events, was executed with good results on phantoms and patients. We think that it can be easily implemented for specific diagnostic problems.

Brain↗
PubMed1977

[Radioimmunologic determination of the thyrotropin releasing hormone].

We describe the preliminary steps for a radio-immunoassay of Thyrotropin Releasing Hormone (TRH). Rabbit antiserum at dilution 1 : 10 000 is used with radioiodinated TRH (125I). We are able to assay from 5 to 1 000 pg unlabeled TRH with an intraassay reporducibility varying from 7 to 4 % and the lowest detectable amount in this system is 10 pg TRH. TRH mean and standard deviation in normal subjects are 136,9 and 25,3 pg/ml.

Female↗