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C Towle

Publications and source records attributed to C Towle.

5 recordsLinked to original sources
PubMed1998

Prevalence of antibodies to adenovirus serotypes 4 and 7 among unimmunized US Army trainees: results of a retrospective nationwide seroprevalence survey.

The 1996 production halt of adenovirus types 4 and 7 vaccines prompted concerns about the resurgence of large respiratory disease outbreaks among US military basic trainees. This serosurvey was conducted to assess the current susceptibility of the trainee population to these viruses. A stratified, random sample (n=303) of trainees' sera was tested using a quantitative colorimetric microneutralization assay to demonstrate antibody titers considered to provide immunologic protection against each adenovirus type. Results were analyzed for relationships between susceptibility and 4 demographic factors-gender, race, prior military service, and age. Results showed that 66% and 73% of trainees were susceptible to serotypes 4 and 7, respectively. Nearly 90% were susceptible to at least one serotype. Susceptibility was significantly (P<.05) related to lack of prior military service and younger age. Consistent with a serosurvey conducted 20 years ago, these results demonstrated significant susceptibility to two vaccine-preventable causes of disease. These findings may have civilian implications.

Adenovirus Infections, Human↗
PubMed1994

Young children's performance on a task sensitive to the memory functions of the medial temporal lobe in adults--the delayed nonmatching-to-sample task--reveals problems that are due to non-memory-related task demands.

Delayed nonmatching-to-sample performance was examined in children and found to be poor from 12 months until almost 2 years even at 5-s delay, although 5 s is well within such children's memory capacity. After 12 months of age, performance did not differ by delay (5 or 30 s). Because children's problems seemed largely unrelated to the task's memory demands, the 2 final studies explored the role of other cognitive abilities (deduction of an abstract rule, speed of processing, and resistance to interference or distraction). Telling children the rule or quadrupling sample presentation time had little effect. Because a salient stimulus (the reward) might interfere with keeping one's attention on the sample, the reward was omitted during initial sample presentation. This helped; at the 5-s delay, 15-month-olds performed at least as well as 21-month-olds in the basic condition, and 12-month-olds performed almost as well. Implications for the cognitive abilities improving during the 2nd year and for the functions of the medial temporal lobe are discussed.

Aptitude↗