Biomedical subjects

C Tracey

Publications and source records attributed to C Tracey.

3 recordsLinked to original sources

PubMed1990

An animal model for mucositis induced by cancer chemotherapy.

Mucositis induced by chemotherapy is a painful and often dose-limiting side effect of cancer therapy. Furthermore, loss of the integrity of the oral epithelium often provides a microbial portal of entry and leads to sepsis. The present study describes the first animal model for chemotherapy-induced mucositis. The combination of three intraperitoneal injections of 5-fluorouracil at 5-day intervals and superficial mechanical mucosal irritation resulted in clinical breakdown of the oral mucosa characterized by ulcerative mucositis in Golden Syrian hamsters. Both clinical and histologic evaluation demonstrated that these changes were similar to those described in human beings and followed a pattern influenced by the degree of myelosuppression. This model should be of significance in establishing the stomatotoxicity of new chemotherapeutic agents, in evaluating medicaments to treat mucositis, and in studying the influence of oral mucosal breakdown on sepsis in myelosuppressed persons.

Animals↗

PubMed1985

A radiographic study of dental development in the hypopituitary dwarf mouse.

Growth in body length, skeletal lengths, incisor lengths and molar root lengths were retarded in dwarf mice. The root lengths of third molars were more severely affected than those of other molars. The crown lengths at the enamel-cementum junction of upper and lower molars of most dwarf mice were significantly shorter than normal. The root canals of dwarf mice were smaller, apical closure was delayed and there was a delay in their eruption to the occlusal level. Although the size of the dentition was markedly affected in the dwarf mice, the functional relationship appeared to be unchanged.

Animals↗

PubMed1985

Root resorption: the aggressive, unerupted second premolar.

Three cases of first molar root resorption, due to impacted maxillary and mandibular second premolars, presented over a period of 5 months. It is suggested that this may not be such an uncommon occurrence as is generally believed. The clinical situations in which the unerupted second premolar may start resorbing first molar roots are described and methods of identifying and treating this problem suggested.

Adolescent↗