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Biomedical subjects

C Trendelenburg

Publications and source records attributed to C Trendelenburg.

At least 19 recordsLinked to original sources
PubMed2001

Reporting cerebrospinal fluid data: knowledge base and interpretation software.

The compilation of cerebrospinal fluid (CSF) patient data together with a graphic display of immunoglobulin patterns in a single CSF report has two main advantages: analytical and clinical plausibility control of a complex set of data improves quality assessment and allows improved clinical specificity and sensitivity for recognition of disease-related "typical" data patterns. The widespread use of automated on-line evaluation programs can now be combined with knowledge-based programs for interpretation by clinical chemists and neurologists. These programs are based on knowledge of neuroimmunology, blood-CSF barrier function and dysfunction, influence of CSF flow on concentrations of blood-derived and brain-derived proteins in CSF, specific intrathecal antibody synthesis and relevance of brain proteins for differential diagnosis of degenerative diseases. The relevance of hyperbolic discrimination functions in quotient diagrams for the detection of intrathecal immunoglobulin synthesis is compared with earlier, still frequently used, linear interpretation functions. Differences found in commercially available interpretation software are discussed.

Brain↗
PubMed1998

Knowledge-based test result in interpretation in laboratory medicine.

The medical interpretation of laboratory test results aims for an optimization of the diagnostic decision process to improve the quality of medical care. It is of growing importance in Clinical Chemistry and Laboratory Medicine. Interpretation is an active process that depends on patient history, experience of the interpreter and local disease prevalences. For the field of Laboratory Medicine the tool Pro.M.D. was developed that enables the medical expert to formulate his knowledge and experience in a knowledge-based system. Nine Pro.M.D. systems are in routine use for knowledge-based test result interpretation at several hospital laboratories today. Our experience in providing clinicians with interpretive reports shows that a medical dialogue on individual findings can be established or improved. With the development of a new, highly differentiated and extensive knowledge base our group introduced a concept called NOTABENE as the basis for new maintenance tools.

Diagnosis, Computer-Assisted↗
PubMed1988

Measurement of activation energy of gamma-glutamyltransferase as a marker for enzyme heterogeneity.

In order to detect differences between various multiple forms of gamma-glutamyltransferase, the activation energy was measured. In the serum of patients with liver diseases, activation energy was measured. In the serum of patients with liver diseases, activation energy of the serum enzyme is higher than in normal individuals (41.9 +/- 1.2 vs. 38.9 +/- 1.5 kJ/mol, p less than 0.05). Neuraminidase treatment resulted in a reduction of activation energy. Various multiple forms of serum gamma-glutamyltransferase, as prepared by lectin affinity chromatography (concanavalin A, Ricinus communis I and II, wheat germ agglutinin) showed activation energy differences between binding and nonbinding fractions. Similar results were observed in seminal plasma gamma-glutamyltransferase, when patients with accessory gland infection were compared with a reference population. Our results suggest that the activation energy depends upon differences in the carbohydrate part of the enzyme. The low gamma-glutamyltransferase activation energy of tissue extracts increased significantly after butanol extraction and was then comparable with serum activation energy values, which suggests that lipid-binding is a factor in activation energy variation. In most cases, gamma-glutamyltransferase activities measured at a certain temperature can be easily converted to a corresponding activity at another temperature, but in severe liver disease significant errors may be introduced when simple temperature conversion factors are used.

Chromatography, Affinity↗
PubMed1982

[Joint study to establish reference values for clinical chemical parameters in childhood (author's transl)].

The working group 'Pädiatrische Klinische Chemie' undertook a joint study to satisfy the need for more reliable reference values for clinical chemical parameters in childhood. In 15 different pediatric hospitals data for the most important clinical chemical parameters were determined for children of different age groups. The children included in the study fulfilled the required minimal criteria concerning their health state. The data were listed according to parameter and age group and the percentiles and mean values with 95% confidence intervals are presented. From these values, reference ranges are derived that are suitable for daily routine analyses.

Alanine Transaminase↗
PubMed1980

[Experimental results after acute and chronic ligation of bile duct (author's transl)].

The bile duct was ligated in 14 bastard dogs. Bilirubine, alcaline phosphatase, GOT, GPT, GLDH, and gamma GT were measured pre- and postoperatively. On the 8th postoperative day stenosis of the choledochus was eliminated using a patch plasty for dilatation in 7 dogs, whereas the occlusion remained in the other 7 dogs. Laboratory and histological results were characteristic for cholestasis 8 days after occlusion; these changes disappeared within 4 weeks after patch plastic surgery. In the controls these parameters normalized as well within 8 weeks, in spite of the persisting occlusion. These results show, that pathological changes after short term cholestasis are fully reversible; they demonstrate as well, that there are compensatory mechanisms operating in dogs with permanent occlusion of the bile duct.

Alanine Transaminase↗
PubMed1979

[On diagnosis of myocardial infarction in the polytraumatized investigation in dogs (author's transl)].

The reliability of CKMB in cases in which damage of sceletal muscles and myocardium occurred in close sequence is tested in dogs. Results show that in simultaneous damage of heart and muscles, CKMB exceeds the requested ratio of 5 to 8% of total CK, thus proving the myocardial infarction. In cases in which myocardial infarction succeeds a damage of sceletal muscle--e.g. a polytrauma --within distance of hours only, the absolutely high level of CKMB proves the infarction, even below the critical ratio of the total CK.

Animals↗
PubMed1978

[Metabolism of endogeneous gastrin (author's transl)].

The localization of production of gastrin is rather well known, the localization of metabolic breakdown however is still being discussed. Liver, kidneys, musculature and small intestine are being taken into consideration. Experiments were performed demonstrating a definite increase of serum gastrin after removal of the small intestine; the duodenum was not removed in these experiments, since enterogastrone is formed mainly in this organ. These results would suggest, that gastrin is metabolized in the small intestine. In order to further prove this point, truncal vagotomy was performed in rabbits, producing elevated serum gastrin levels. In other series subtotal removal of the small intestine was combined with truncal vagotomy. Serum gastrin levels were definitely higher after this latter procedure than after truncal vagotomy alone. These findings seem to support the hypothesis, that endogeneous gastrin is metabolized in the small intestine.

Animals↗
PubMed1976

[Behavior of intestinal motility and serum gastrin level after administration of prostaglandin A1, E1 and F2alpha in recent mechanical ileus of the rabbit].

In a mechanical ileus model in 70 rabbits, the effects of PGF2alpha-infusions, PGE1- and PGA1-injections on jejunal pressure and serum gastrin levels were studied. PGF2alpha increases, whereas PGE1 inhibits jejunal motility. PGA1 produces no significant response. A modulation of neurotransmission is discussed. The serum gastrin levels can be decreased by PGE1-injections, whereas PGA1 effects only small decreases. The importance of the vagal mechanism for the release of gastrin is emphasized.

Animals↗