Biomedical subjects
Publications and source records attributed to C Triantaphyllidis.
The C3 complement types were studied in 463 patients with thyroid diseases and in 211 controls. There were no significant differences with respect to gene or phenotype frequencies between patient groups and controls. In the total sample, the gene frequencies are similar to those found in other European populations.
Aminoglycoside antibiotics inhibit contractility of the isolated guinea pig vas deferens in a dose-related manner. However, total inhibition of the contractility cannot be attained, a phenomenon most probably attributed to the partial inhibition of the function of Ca channels by the antibiotics. The inhibitory potency of aminoglycoside antibiotics was found to be: sisomicin greater than gentamicin greater than netilmicin greater than streptomycin greater than dactimicin greater than amikacin greater than kanamycin greater than kanendomycin greater than dibekacin greater than tobramycin. Ca2+ antagonize the action of aminoglycoside antibiotics on the vas deferens competitively. This observation indicates that the untoward effect of aminoglycoside antibiotics on contractility of the vas deferens can be attributed to their ability to interfere with Ca2+ entry through cell membranes of the tissue, a prerequisite for subsequent contraction. Above a specific threshold (7.5 mM) Ca2+ have a prophylactic effect on vas deferens and prevent the inhibitory action of ICmax doses of the antibiotics. Thus, Ca could be used as a prophylactic medium or as an antidote in restoring contractility of the vas deferens if it is inhibited by aminoglycoside antibiotics.
Variations at the PGM1, GOTm, GOTs, and EsD loci were studied in placental samples from Northern Greece. The gene frequencies of GOTm and GOTs were found to be comparable with frequencies reported in other Caucasian populations. The frequencies of the EsD and PGMa11 alleles, however, were lower in Northern Greece than in other European populations.
In the present study the interaction of aminoglycoside antibiotics with oxytocin and prostaglandin E2 on the contractility of the rat uterus was investigated. It was found that oxytocin and prostaglandin E2 were able to completely reverse the uterine relaxing effect of aminoglycoside antibiotics and when administered concomitantly they exert a protective action. These findings support the view that aminoglycoside antibiotics affect superficially bound extracellular calcium only, since oxytocin and prostaglandins primarily act on intracellular calcium.
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The aminoglycoside antibiotics possess neuromuscular blocking activity; the potency of those antibiotics tested appears to be as follows: gentamicin greater than streptomycin greater than amikacin greater than sisomicin greater than kanamycin = tobramycin greater than kanendomycin = dibekacin. The neuromuscular blockade produced by these antibiotics is not reversed by neostigmine, whereas it is reversed by calcium. Calcium not only has the ability to restore the neuromuscular transmission but also to exert protective action against the neuromuscular blocking activity of aminoglycoside antibiotics; these antibiotics are also potentially capable of interacting with non-depolarizing muscle relaxant drugs (d-tubocurarine, pancuronium) or propranolol, a beta-adrenergic receptor blocking agent. This interaction results in respiratory depression and/or prolonged apnoea. Our findings lead to the assumption that amino-glycoside antibiotics are involved in the process of acetylcholine release by nerve impulses, antagonizing calcium ions.
Analysis at 20 genetic loci by starch gel electrophoresis of a population from Greece shows that contrary to most accepted views, the outdoor Eastern Mediterranean Short-tailed Mouse (i) does not belong to the same species as the House Mouse (Mus musculus), (ii) is not less distant from the Eastern European semi-species of House Mouse (biochemical group 2) than from the Western and Mediterranean European semi-species (group 1), and (iii) is not more closely related to the outdoor Western Mediterranean Short-tailed Mouse Mus spretus (group 3), than to M. musculus. It represents a new biochemical group (group 4) and deserves a species rank (Mus spicilegus).
Aminodeoxykanamycin (Kaneudomycin) as well as other members of the aminoglycoside antibiotics, has an action at the neuromuscular junction. Kanendomycin was found to be five times less potent than gentamycin, as far as their neuromuscular blocking action on the rat diaphragm is concerned. The neuromuscular blocking action on the rat diaphragm is concerned. The neuromuscular blockade produced by Kanendomycin is not reversed by neostigmine but only by calcium chloride.
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