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C Trinn

Publications and source records attributed to C Trinn.

26 records · Page 2Linked to original sources
PubMed1984

The role of the tubulointerstitial changes in the prognosis of IgA glomerulonephritis.

The authors investigated the tubulointerstitial changes (atrophic tubuli, interstitial fibrosis and round-cell infiltration) by two methods in renal biopsies from 56 patients with IgA glomerulonephritis. A statistically significant correlation was found to exist between the tubulointerstitial changes and serum creatinine level at the time of renal biopsy. A statistical significant correlation was also established between serum creatinine at the end of a period of 5 years of follow-up and tubulointerstitial changes. Their results suggest that severe tubulointerstitial lesions in IgA glomerulonephritis carry a poor prognosis.

Adolescent↗
PubMed1984

Herpes virus antigens and antibodies in kidney biopsies and sera of IgA glomerulonephritic patients.

Antibody titers against 4 viruses of the herpes group have been studied in the sera of 54 patients with IgA glomerulonephritis (GN). The incidence of antibodies to herpes simplex virus type-1 (HSV-1), HSV-2, cytomegalovirus (CMV), Epstein-Barr virus nuclear antigen (EBNA), and that of IgG antibodies to EBV virus capsid antigen (VCA) were similar in patients and in controls. However, elevated antibody titers (greater than or equal to 64) to HSV and CMV occurred more frequently in patients with IgA GN than in healthy controls. Geometric mean titers to HSV and CMV were also higher in patients suffering from IgA GN than in controls. The incidence of IgA antibodies to EBV VCA occurred in patients with IgA GN significantly more often than in controls. There was a trace amount of HSV-2 antigen in 2 glomeruli of 1 renal biopsy. It is concluded that, in some patients with IgA GN, there is an abnormal immune response to certain types of herpes viruses.

Adolescent↗
PubMed1984

IgA glomerulonephritis: light microscopic and immunohistological studies.

Renal biopsy material of 50 patients suffering from IgA glomerulonephritis was studied by light microscopy, immunofluorescence and occasionally electron microscopy. Associated with a uniform immunohistological pattern mainly focal or diffuse mesangial proliferative glomerulonephritis was found. In addition to the glomerular changes the importance of frequent extraglomerular, mainly vascular and interstitial, alterations is stressed. In arterioles and arteries, deposition of a hyalinous substance was observed. Immunohistology revealed the presence of immunoglobulins and/or C3 in the vessels. In the interstitium fibrinogen/fibrin was often seen, accompanied by chronic inflammatory infiltration and fibrosis.

Arteries↗
PubMed1982

Circulating immune complexes in patients with IgA glomerulonephritis.

Fourty-four patients with IgA-glomerulonephritis (IgA GN) were studied for circulating immune complexes (IC) repeatedly in the course of disease on the evidence of four different methods suited for the detection of IC, viz. complement consumption assay, Clq-solubility test and two tests based on PEG-precipitation, and of indirect signs pointing to the presence of IC. Joint assessment of the direct and indirect signs (positivity of a minimum of 2 indirect signs or any of the direct signs) permitted to ascertain the presence of circulating IC in 72 per cent of the patients and in 63.3 per cent of the examined sera. There was no close relationship between the presence of IC and the clinical activity. On the other hand, in 16 patients positive for the rheumatoid factor (RF) the renal biopsy material revealed extensive vascular lesions. The findings suggest that the circulating IC, some of which contain RF, play a part in the pathomechanism of IgA GN and are involved in the production of the vascular abnormalities in this disease.

Adolescent↗
PubMed1982

Clinical features and course of IgA glomerulonephritis.

A review of the clinical features, laboratory findings and course in 50 cases of IgA glomerulonephritis confirmed by biopsy is presented. The onset and clinical course of the process was oligosymptomatic in the majority of the cases with a predominance of microhematuria and persistent proteinuria. By the end of the observation period more than 50 per cent of the patients became hypertensive and in 16 cases serum creatinine levels attained 132 mumol/l (1.5 mg per 100 ml) or more. Proteinuria in excess of 1 g/24h, hypertension and an impaired concentration capacity at the onset heralded early progression.

Adolescent↗