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Biomedical subjects

C Turton

Publications and source records attributed to C Turton.

11 recordsLinked to original sources

Bronchoscopic findings in a case of bronchopulmonary histoplasmosis.

At bronchoscopic examination extensive areas of fibrinous slough covering bronchial mucosal inflammation and ulceration were seen in a case of progressive diffuse bronchopulmonary histoplasmosis. Rigid bronchoscopy was needed to obtain sufficient biopsy material for specific histological diagnosis.

Amphotericin B↗

Optical mapping of the thoracoabdominal wall.

An optical technique has been developed for mapping the size and shape of the thoracoabdominal wall and the change in its shape with breathing. A fixed pattern composed of stripes of light is projected on to both sides of the trunk. These stripes become distorted when viewed from in front and behind, forming contours over the trunk surface. The contours are photographed and then encoded digitally. The digital information can be used to compute automatically the volume of the trunk, the position of any point on its surface, and its cross sectional shape at any level. The technique has been tested on rigid objects (a globe, a cone, and two dummy torsos) that can be measured precisely. With this optical technique linear dimensions can be calculated to within 0.5 mm, cross sectional area to within 5%, and volume to within 1.6-3.7%. These results suggest that this non-invasive technique measures the shape and volume of complex three dimensional surfaces with sufficient accuracy to be tried in clinical practice.

Abdominal Muscles↗

Cryptogenic fibrosing alveolitis associated with peripheral neuropathy.

Eight patients who presented with fibrosing alveolitis and developed peripheral neuropathy are described. Seven had a positive rheumatoid factor, but only one had arthritis. The neuropathy affected both motor and sensory fibres. Two patients underwent peripheral nerve biopsy, one showing vasculitis and the other an axonal neuropathy. The two disorders responded differently to corticosteroid therapy, and immunosuppressant drugs may be useful in treating the neuropathy. The similarities of the patients suggests that this uncommon association is a real category.

Aged↗

Bronchoalveolar lavage for the preparation of free lung cells: technique and complications.

Bronchoalveolar lavage at fibreoptic bronchoscopy enables the peripheral bronchoalveolar free cell population, which consists mainly of lymphocytes and macrophages, to be sampled. The yield is sufficient for detailed morphological and functional investigation of these cells, which can be separated by exploiting the glass-adherent or phagocytic properties of macrophages. Such studies are of particular interest in patients with recurrent chest infections, to detect abnormalities of local cellular immunity; in pulmonary fibrosis to assess activity of the disease and effect of treatment by observing morphology and testing function of free lung cells; and in bronchial carcinoma to investigate local immune responses to the tumour. The procedure is held to be ethical in these circumstances. The lavage consists of irrigation of a segmental bronchus through the fibreoptic bronchoscope with up to 500 ml pH-corrected normal saline solution. It is contraindicated in those with respiratory or cardiac risk, but is tolerated well by most patients. Complications include acute respiratory distress, vasovagal syncope and fever with pulmonary infiltrates. Lavage is associated with a mean fall of PaO2 of 3.0 kPa (22.7 mmHg) and routine oxygen supplementation is recommended.

Cell Separation↗