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Biomedical subjects

C V Harrison

Publications and source records attributed to C V Harrison.

14 recordsLinked to original sources
PubMed1978

Non-tropical 'idiopathic splenomegaly': a follow-up study of ten patients described in 1969.

The later history is described of four of 10 patients who were reported in 1969 as suffering from non-tropical 'idiopathic splenomegaly'. Two of the four patients developed malignant lymphomas 6 years and 2 years, respectively, after splenectomy but the two other patients have lived for 17 and 15 years, respectively, without developing any signs of a malignant tumour. Thus, four of the original 10 patients have developed malignant's lymphomas. The histology of the patients' spleens has been reviewed in the light of their clinical history, but no criteria have been found which are of clear prognostic value. However, with hindsight it was possible to recognize some cytological abnormality in the spleens in three out of the four patients who developed malignant lymphomas, and it appears that unless the cell population in both the red and white pulp is strictly normal, the patient is likely to develop a malignant lymphoma. The tumours which subsequently developed showed no special or characteristic features. The title 'idiopathic splenomegaly' is clearly unsatisfactory but the alternative 'chronic lymphocytic lymphoma with hypersplenism', although appropriate for the illness of the patients who developed malignant lymphomas, is inappropriate for those in which the pathological process seems not to be neoplastic.

Aged↗
PubMed1973

Electron microscope study of a case of Australia antigen-positive chronic hepatitis.

The laboratory findings in a case of Australia antigen (Au-Ag) positive chronic hepatitis in a 4-year-old boy are given. Studies by the electron microscope technique of thin sectioning revealed the presence of 200A particles in the nuclei of hepatocytes. These particles are identical to those described previously in occasional specimens of Au-Ag-positive liver tissue. However, the pattern found here differs from previous descriptions inasmuch as no heavily infected nuclei could be found but almost all nuclei could be shown to contain extremely small numbers of these particles. The significance of this finding is discussed and the danger that it would be easy to obtain false negatives in similar tissue pointed out.

Bile Ducts↗
PubMed1972

The morphology of the lymph node in the macroglobulinaemia of Waldenström.

In 16 cases of Waldenström's macroglobulinaemia the following findings were sufficiently frequent to justify a provisional diagnosis: a modestly enlarged node with lymphocytic infiltration through the capsule into the adjacent connective tissue, retention of the sinus and medullary reticulin pattern, few or no peripheral follicles, sinuses marked out by pale histiocytes, scanty mitoses, numerous plasma cells, and dark staining of plasma in blood vessels. Mast cells were not more frequent than in reactive nodes, but were more frequent than in lymphomas. Periodic acid-Schiff-positive inclusions were found in every case, but were usually very scanty. Similar inclusions can rarely be found in other cases.

Adipose Tissue↗
PubMed1972

The diagnosis of Hodgkin's disease in surgically excised spleens.

A series of 44 spleens removed from patients with Hodgkin's disease before treatment has been reviewed. The difficulties encountered in detecting foci of Hodgkin's tissue and the histological features and characteristics of early invasion are described.

Adolescent↗
PubMed1972

Angiofollicular lymph node hyperplasia (Castleman).

Six personally observed cases of this lesion are reported and the literature is reviewed. One hundred and thirty-four cases have been reported to date. The lesion has occurred in many sites, but is commonest in the thorax (60%), abdomen (11%), neck (14%), and axilla (4%). Ninety per cent of cases are symptomless or have only the pressure symptoms, 10% have systemic signs, namely, fever, raised ESR, anaemia, cured by removal of the tumour. These cases have a slightly different histology. All recorded cases have been benign. Microscopically the lesion is follicular but instead of germinal centres the follicles have one or more thick-walled arteries and often some surrounding histiocytes. Increased numbers of vessels occur between the follicles, whilst sinuses are absent. These vessels have thick, cellular walls like post-capillary venules. Sometimes they become hyaline. The cases with symptoms have true reaction centres as well as a few intrafollicular vessels. Between the follicles there are increased numbers of vessels and, in addition, there may be collections of plasma cells or eosinophils.

Adult↗
PubMed1971

The pathological findings following laparotomy in Hodgkin's disease.

The pathological findings in 50 patients with Hodgkin's disease following laparotomy for diagnostic purposes are described. Forty-four patients had laparotomy before treatment and within a few months of the original diagnosis, while 6 patients had delayed laparotomies. The Rye histological classification was applied to the original lymph node biopsy, the abdominal lymph node and Hodgkin's tissue in the spleen. The variation in appearance both of these tissues and of the liver biopsies is discussed.

Adolescent↗