Biomedical subjects

C V Migliazzo

Publications and source records attributed to C V Migliazzo.

6 recordsLinked to original sources

PubMed1994

Does saving time using FASTPAC or suprathreshold testing reduce quality of visual fields?

PURPOSE: To compare the clinical performance of two time-saving test strategies in detecting visual field abnormalities. METHODS: One eye of 48 healthy subjects and 87 patients with glaucoma and early visual field loss was tested with the Humphrey perimeter. After an initial 24-2 standard threshold test, three tests using the 24-2 array of test locations were performed in randomized order: standard threshold strategy, FASTPAC threshold strategy, and threshold-related suprathreshold screening strategy. The initial 24-2 test was used as the "gold standard" against which the other three tests were compared. RESULTS: Mean threshold values were 0.3 decibels more sensitive using FASTPAC than the standard threshold test, whereas short-term fluctuation was 0.5 decibels larger. Measured using different criteria for abnormality, sensitivity and specificity of FASTPAC were no different than those of the standard threshold test, but they were better than the suprathreshold screening. Using a very sensitive measure of defect detection in ten different clusters within the field, the standard strategy and FASTPAC performed similarly yet significantly better than the suprathreshold test. CONCLUSIONS: In healthy subjects and patients with early glaucoma, FASTPAC saves 40% of test time without a significant deterioration in defect detection, whereas 52-point suprathreshold screening is not a clinically acceptable alternative.

Adult↗

PubMed1989

[Argon laser treatment of filtering bleb insufficiency].

The present paper reports on experience with a new contact lens which enables monophilic fixation sutures of the scleral flap to be severed transconjunctivally using highly focussed argon laser beams. The procedure is used in the early postoperative period on patients with failing filtering blebs. Indications and the procedures itself are described in detail.

Contact Lenses↗

PubMed1986

Long-term analysis of pigmentary dispersion syndrome and pigmentary glaucoma.

A retrospective, longitudinal study of 129 eyes in 65 patients with pigmentary dispersion syndrome and either ocular hypertension of glaucoma was undertaken. The mean follow-up period was 17 years (range, 5-35 years). Visual acuity, intraocular pressure (IOP), visual field loss, pigment grade, Krukenberg spindle, iris transillumination, medications, and surgeries were analyzed for each patient at 5-year intervals from 1960 through 1983. Disc and field changes developed in 35% of patients with pigment dispersion syndrome and ocular hypertension during the study period. The long-term prognosis of the medical and surgical management of pigmentary glaucoma is discussed.

Adult↗

PubMed1985

Clinical experience with timolol in childhood glaucoma.

We studied 67 patients (100 eyes) with childhood glaucoma who were treated with timolol maleate. Thirty of these patients (40 eyes) did not require additional surgery or medications after being treated with timolol (follow-up, from six to 60 months). Thirty-one eyes (78%) in this group had a pressure drop; 18 eyes (45%) had a pressure drop of greater than 10 mm Hg. We conclude that timolol is effective in the treatment of pediatric glaucoma, although there is a need to be aware of its potential complications.

Adolescent↗

PubMed1984

Laser iridectomy--a technique for blue irises.

A two-step technique for laser iridectomy in light blue irises is described, which simplifies penetration of these irises and allows success rates approaching 100%. Step one utilizes a high energy, long duration, predominantly thermal laser burn that destroys overlying iris stroma. In step two, the laser energy is reduced and exposure time is shortened to facilitate removal of remaining pigment epithelium.

Argon↗

PubMed1977

Secondary effects of aganglionosis in the piebald-lethal mouse model of Hirschsprung's disease.

An attempt was made to identify the factors secondary to fecal stasis and megacolon that are related to overall debilitation and eventual death of the piebald mouse. The piebald mouse showed periodic leukocytosis and bacteremia that were associated with lesions in the mucosal surface of the megacolon. Defective growth, loss of weight, and retardation of development with megacolon were documented by systematic study of body weight and of the relationship between body weight and organ weights. Alterations in body weight and in organ weight to body weight ratios were parallel in the piebald mouse, in mice with imperforate anus, and in mice with surgically-induced megacolon. Histologic studies confirmed a pattern of hypertrophy of the muscularis externa in the piebald mouse. The body temperature was lower than for normal siblings, but the sodium, potassium, and water content of the feces, the general blood chemistry profiles, and the intestinal microflora did not differ from those of the normal mouse. There was no evidence of bacterial overgrowth in the small intestine of the piebald mouse with fecal stasis and megacolon.

Animals↗