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Biomedical subjects

C V Perrill

Publications and source records attributed to C V Perrill.

9 recordsLinked to original sources
PubMed1979

Glycogen synthase activation in human skeletal muscle: effects of diet and exercise.

We investigated the role of glycogen synthase in supranormal resynthesis (supercompensation) of skeletal muscle glycogen after exhaustive exercise. Six healthy men exercised 60 min by cycling with one leg at 75% VO2max, recovered 3 days on a low-carbohydrate diet, exercised again, and recovered 4 days on high-carbohydrate diet. Glycogen and glycogen synthase activities at several glucose-6-phosphate (G6P) concentrations were measured in biopsy samples of m. vastus lateralis. Dietary alterations alone did not affect glycogen, whereas exercise depleted glycogen stores. After the second exercise bout, glycogen returned to normal within 24 h and reached supercompensated levels by 48 h of recovery. Glycogen synthase activation state strikingly increased after exercise in exercised muscle and remained somewhat elevated for the first 48 h of recovery in both muscles. We suggest that 1) forms of glycogen synthase intermediate to I (G6P-independent) and D (G6P-dependent) forms are present in vivo, and 2) glycogen supercompensation can in part be explained by the formation of intermediate forms of glycogen synthase that exhibit relatively low activity ratios, but an increased sensitivity to activation by G6P.

Adult↗
PubMed1976

The sharp dissector as an aid to better surgical procedures.

Various types of bone scrapers, skin scratchers and dissectors have been devised by practitioners. However, in modern operating rooms, a well sharpened general dissector is rarely seen. Experience in doing a wide range of surgical procedures indicated that well crafted dissectors with hollow-ground blades can improve the speed and accuracy of the surgeon as well as reduce the bleeding. The blades of these dissectors should be contra-angled and always kept sharp. To reduce expense, disposable round-ended blades, factory sharpened, could slide into the firmly gripping chucks of suitable handles.

Surgical Instruments↗