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Biomedical subjects

C V Ramakrishnan

Publications and source records attributed to C V Ramakrishnan.

At least 37 records · Page 2Linked to original sources
PubMed1983

Effects of preweaning undernutrition and continued postweaning protein deficiency or nutritional rehabilitation on polyphosphoinositides in rat brain.

Metabolically inert polyphosphoinositides seem to play an important role in the structural development of neurons, glia, and myelin. The metabolically active pool of PhIpp appears to be important for the functional development of glia and myelin during the postweaning period, whereas PhIp seems to be more important for the functional development of neurons during the preweaning period. Neonatal undernutrition reduces the concentrations of structural polyphosphoinositides and metabolic PhIp while metabolic PhIpp remains unaltered. These effects can be reversed by postweaning nutritional rehabilitation. A continued postweaning protein deficiency of neonatally undernourished rats affects structural PhIpp more than PhIp. Metabolically active PhIpp is drastically reduced.

Animals↗
PubMed1980

Influence of thyroxine on suckling rat intestinal alkaline phosphatase and effects of undernutrition on the same.

Administration of daily doses of L-thyroxine to rats from 18-20 days, but not from 4-7, 11-13, or 25-27 days of age, increased intestinal alkaline phosphatase activity. The typical anterior-to-posterior gradient in the enzyme activity was abolished in the hormone-treated (18-20 days of age) rat small intestine (thyroxine prevented the fall of the enzyme activity occurring at weaning in the distal part of the small intestine). Thyroidectomy at 14 days of age decreased the enzyme activity (units/gm wet tissue) in the distal part of the small intestine at 21 days of age, but the enzyme activity was unaltered in the duodenum. The enzyme activity in the distal part of the small intestine of pups undernourished by maternal protein deficiency is not influenced by the hormone administration, even from 18-20 days of age, strengthening the hypothesis that failure of maturation of alkaline phosphatase occurs as a result of neonatal undernutrition.

Age Factors↗
PubMed1979

Differential developmental pattern of acid and alkaline phytase and phosphatase activities in rat intestine.

Rat intestine was found to show a distinct acid phytase activity (pH optimum 4.7) in addition to that of an alkaline phytase (pH optimum 8.0). The phytase and phosphatase activities were found to differ in their developmental pattern and responded differentially to some inhibitors. Thus the two activities seem to be due to two independent enzymes and are not the activity of a nonspecific phosphatase as has been suspected formerly.

6-Phytase↗
PubMed1978

Effect of prenatal and neonatal pantothenic acid deficiency on rat intestinal phosphatases.

Alkaline phosphatase activity was increased in the distal part of the small intestine of pantothenic acid deficient neonatal rats, while acid phosphatase activity was slightly increased and protein concentration was decreased throughout the small intestine. The growth and maturation of the distal part of the small intestine were retarded more severely than in the proximal part.

Acid Phosphatase↗
PubMed1976

Retreatment of drug-sensitive relapses of pulmonary tuberculosis following chemotherapy with standard drugs.

Forty-four tuberculous patients who relapsed with strains sensitive to the initial drugs they had received, namely streptomycin and isoniazid, were retreated with the same drugs for a year. One died of tuberculosis, and two had treatment changed for unfavourable response. All the other 41 showed a bacteriological response, and all but one were culture-negative at 1 year or when last assessed.

Aminosalicylic Acid↗
PubMed1976

Study of adverse reactions to a once-weekly regimen of streptomycin plus a slow-release preparation of isoniazid in high dosage for six months.

A once-weekly regimen of streptomycin (1 g) plus a slow-release preparation of isoniazid (matrix isoniazid) in high dosage, namely 50 mg/kg body-weight for rapid inactivators of isoniazid and 35 mg/kg for slow inactivators, was prescribed for 6 months to 64 tuberculous patients (27 rapid, 37 slow). The regimen was tolerated by most the of the patients. However, 4 rapid and 3 slow inactivators had a modification of the regimen, mainly for giddiness. There were no cases of peripheral neuropathy. No adverse effects on haemopoiesis or hepatic or renal functions were observed in any of the patients. It is concluded that it is feasible to administer matrix isoniazid in dosages considerably higher than ordinary isoniazid, in once-weekly chemotherapy.

Adolescent↗