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Biomedical subjects

C V Reyes

Publications and source records attributed to C V Reyes.

At least 19 recordsLinked to original sources

Cardiac hemangioma.

Hemangiomas are uncommon primary tumors of the heart. Most of them are found incidentally at autopsy, during clinical evaluation, or cardiac surgery. Occasionally, a protean clinical picture is manifested, including valvular disorder, arrhythmias, obstruction of coronary artery and other significant vasculature, pericardial effusion, and embolic phenomena. Catheterization, angiography, and echocardiography all play some important role in the antemortem diagnosis of this cardiac tumor. The treatment of choice is simple complete excision. In this review, we add our experience with cardiac hemangiomas: one incidentally discovered at autopsy and another found during coronary artery bypass surgery.

Adolescent

Amphicrine carcinoma of the lung. Diagnosis by fine needle aspiration cytology.

A case of pulmonary carcinoma with dual (glandular and endocrine) differentiation diagnosed by fine needle aspiration cytology is reported. By light microscopy, the neoplastic cells showed mucicarmine, periodic-acid Schiff, and Grimelius silver positivity. On immunostaining, neuron specific enolase, chromogranin, calcitonin and serotonin were demonstrated. Electron microscopy revealed two different types of distinctive cytoplasmic inclusions in the same cell, namely: carcinoid type of neurosecretory granules and mucin droplets. Diagnostic criteria and possible histogenesis of this rare tumour entity are discussed.

Biopsy, Needle

The potential risk of thrombosis during coronary angiography using nonionic contrast media.

The influence of contrast media on coagulation has an important association with thromboembolic complication during coronary angiography. In this study, whole blood was methodically mixed with nonionic contrast medium, Iohexol (IOH), conventional ionic contrast medium, Hypaque-76 (H76), and low osmolar ionic dimer Hexabrix (HB) in vitro. The thrombotic propensity of contrast agents can be evaluated by measuring the clot formation of the mixtures. The experiments were repeated with whole blood after systemic heparinization. In the in vitro study, 5 ml of canine (N = 10) and 3 ml of human (N = 11) whole blood was incubated for 30 min in glass tubes with equal volumes of IOH, H76, HB, and 0.9% NaCl before heparinization. Clot formation with IOH and 0.9% NaCl were seen both in dogs (4.0 +/- 0.7 gm and 5.6 +/- 0.8 gm) and in patients (1.4 +/- 0.9 gm and 2.9 +/- 1.3 gm), whereas no clot was seen with H76 or XB. Following heparinization, no clot was visualized in any mixture of whole blood with contrast media or 0.9% NaCl. Similar results were observed in the catheter-syringe system with canine blood (N = 11) mixed with the contrast agents. Blood clots found in 15 min and 30 min of IOH were 0.07 +/- 0.08 gm and 0.44 +/- 0.20 gm (P less than 0.01) and of NaCl were 0.29 +/- 0.37 gm and 0.69 +/- 0.38 gm (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Angiography

Resolution of secondary amyloidosis 14 years after adequate chemotherapy for skeletal tuberculosis.

Despite available chemotherapy, survival of patients with skeletal tuberculosis and secondary amyloidosis for more than five years is extremely unusual. We have described a patient with inadequately treated tuberculous osteomyelitis and later concomitant pulmonary tuberculosis and secondary amyloidosis. After a prolonged course of antituberculous chemotherapy, the patient was found to be cured of the tuberculosis and to have complete resolution of the amyloidosis 14 years after the diagnosis.

Aged

Fine needle aspiration cytology of hepatocellular carcinoma manifested as bone metastasis.

Symptomatic skeletal metastasis in hepatocellular carcinoma is rare. We have presented two cases of expansile, lytic lesions involving the distal radius and sacrococcyx, respectively. Initially, diagnosis was made by fine needle aspiration cytology, complemented by positive alpha-fetoprotein immunoperoxidase staining in one and ultrastructural evaluation in both.

Adenocarcinoma

Subcutaneous blastomycosis: diagnosis by fine-needle aspiration cytology.

Blastomycosis is a rare disease. Fine-needle aspiration of nodules and neck masses is generally well accepted for head and neck cancer. This method has recently been used to make a rapid diagnosis of blastomycosis so that therapy could be instituted before the usual 4 to 6 week delay that is necessary for fungal cultures to mature. We believe this technique is reliable, provided the services of an experienced cytopathologist are available. The current treatment for blastomycosis is amphotericin B or ketoconazole, though newer antifungal agents hold promise for the treatment of this disease in the future.

Biopsy, Needle

Chondrosarcoma of the larynx.

Two cases of laryngeal chondrosarcoma are described. The first exhibited a fibrosarcomatous differentiation, which is a rare finding in chondrosarcoma and usually indicates poor prognosis. The second was found in a larynx six years after Teflon injections for the treatment of vocal cord paralysis. The possibility of Teflon as a tumorigenic factor in this case is raised.

Aged

Hepatocellular carcinoma with bone metastasis.

The autopsy of hepatocellular carcinoma at Hines VA Hospital was reviewed for a 33-year period, between 1954 and 1986. The neoplasm is uncommon and bone involvement was observed in 7.3% or in ten of 137 cases. A clinical presentation of osseous metastasis in hepatocellular carcinoma is rare. A brief literature review is also included.

Aged

Progressive multifocal leukoencephalopathy.

Progressive multifocal leukoencephalopathy, a demyelinating disease of the central nervous system, is caused by a polyomavirus. This opportunistic virus is demonstrable in affected brain tissue obtained by biopsy or at autopsy. The disease commonly occurs in immunocompromised patients secondary to lymphoproliferative disease, immunosuppressive therapy, autoimmune disorders and acquired immunodeficiency syndrome. The prognosis is poor.

Adult

Myasthenic syndrome (Eaton-Lambert syndrome) associated with pulmonary adenocarcinoma.

A case of a 57-year-old man who presented with the clinical features of Eaton-Lambert syndrome preceding the diagnosis of lung adenocarcinoma at autopsy by 7 years, is reported. Although myasthenic syndrome is intimately associated with pulmonary small cell carcinoma, which connotes a grave prognosis, a small percentage of the tumor can be squamous cell carcinoma or adenocarcinoma, which may be resectable. Therefore, a continued search for evidence of intrathoracic neoplasm must be pursued following manifestations of myasthenic syndrome.

Adenocarcinoma

Changing incidence of adenocarcinoma of the lung: a brief review.

The autopsy of lung cancer at Hines Veterans Administration Hospital was reviewed for a 27-year period, between 1957 and 1983. There has been a changing histologic pattern with a recent increase in adenocarcinoma and a relative decrease of the other cell types. This observation, based on a virtually all-male patient population, is partly attributed to better and improved diagnostic procedures.

Adenocarcinoma

Small cell carcinoma of the urinary bladder with hypercalcemia.

This report describes three cases of undifferentiated small cell carcinoma of the urinary bladder. Their light microscopic appearance is closely akin to the small cell carcinoma of lung. The neoplastic cells exhibit few cytoplasmic dense core neurosecretory granules ultrastructurally and immunoreactivity to enolase. Two patients manifested clinically hypercalcemia which is rare in small cell carcinoma in general and, to the best of our knowledge, has not been described in association with bladder small cell carcinoma.

Aged

Cardiac tamponade in lung cancer.

Neoplastic cardiac tamponade is extraordinary and dramatic as an initial presentation of cancer and not so unusual as a late complication. Five clinically and microscopically confirmed cases of cardiac tamponade as the first manifestation of pulmonary adenocarcinoma are reported along with a review of pertinent literature.

Adenocarcinoma