Idiopathic granulomatous mastitis.
A case of idiopathic granulomatous mastitis mimicking breast carcinoma clinically and radiographically is reported with mammography, sonography and MR images.
Adult↗
Biomedical subjects
C Van Ongeval
Publications and source records attributed to C Van Ongeval.
[Mammographic symptomatology of malignant breast lesions].
Malignant breast images may include opacities (stellar--rounded with blurred margins), microcalcifications, opacities with microcalcifications, asymmetric fibroglandular tissue, or distortion of the mammographic pattern. Secondary signs may also be present, such as skin thickening, skin or nipple retraction, prominent vascularisation, axillary lymph nodes. The aim of this paper is to describe the different aspects and to make the differential diagnosis from benign tumors and normal tissue.
Breast↗
[Galactography].
Spontaneous single duct discharge is the main indication for galactography. This abnormality has in most cases a benign aetiology (> 90%). With a meticulous technique and sufficient experience, the ducts can be cannulated in 95% of the cases. A nipple adenoma with a blood stained discharge is seldom to pass for cannulation. Because cytology of the nipple discharge is not always positive in case of intraductal proliferations, microdochectomy must be used to obtain the differential diagnosis. Galactography shows multiple normal duct variations, depending on age, surrounding tissue, and a possible history of lactation. Pathologic images can be seen in dystrophic breasts, solitary papillomas, (juvenile) papillomas or (intraductal) carcinomas. In addition to high frequency ultrasonography (> or = 10 MHz), which is able to visualise the retro-areolar and superficial ducts, galactography can give a more detailed and better overview of the pathology.
Adult↗
Case report 842. Benign hibernoma.
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Adult↗
Adamantinoma of the tibia: MRI documentation.
We report two cases of adamantinoma of the tibia, for which an MR examination was performed. Each patient was initially investigated with plain radiography and in case 2, a computerized tomography was also performed. The MR characteristics of this tumor are scarcely documented in the even few case reports of this tumor. MRI does not add to the (differential) diagnosis but does have significance in the preoperative staging because it allows adequate delineation of tumor, which is essential for a complete and curative resection of the tumor.
Adolescent↗
Parosteal osteosarcoma.
A case of parosteal osteosarcoma is reported. In spite of the pathognomonic plain radiographic signs of parosteal osteosarcoma, it is very uneasy to differentiate it from myositis ossificans circumscripta in the mature stage. CT and MRI defined the extent of the tumor into the soft tissue, the medullary and cortical invasion and gave more information about the composition of the lesion.
Adult↗
Ventricular enlargement, clinical correlates and treatment outcome in chronic schizophrenic inpatients.
The ventricle-brain ratio (VBR) of 42 chronic schizophrenic patients was compared with that of 42 age-matched medical controls. For the schizophrenics, the relationship of various clinical parameters to the VBR was assessed, and the outcome of 12 weeks of double-blind treatment with either risperidone or haloperidol. The results confirm that schizophrenic patients have slightly enlarged lateral ventricles compared with medical controls. Only for schizophrenics, an effect of age, but not of duration of illness, was noticed. This study does not support the validity of a clinical subdivision of chronic schizophrenic patients on the basis of the VBR. Neither negative, positive nor general psychopathological symptoms, as measured by the Positive and Negative Syndrome Scale for Schizophrenia (PANSS), were related to the VBR, nor were abnormal involuntary movements or extrapyramidal symptoms. No association between season of birth or a family history of major mental disorder and VBR could be demonstrated. Treatment response was predicted by the total PANSS score and the PANSS general psychopathology subscale score at baseline. There was a trend for patients with higher VBR to have a more or haloperidol). or haloperidol).
Adult↗
NMR imaging study of the pharmacodynamics of polylysine-gadolinium-DTPA in the rabbit and the rat.
The pharmacodynamics of polylysine-(Gd-DTPA) (Schering, Berlin, Germany), a new blood pooling contrast agent for MRI, were studied in the rabbit and the rat. Polylysine-(Gd-DTPA) is a compound with high LD50. Due to its high molecular weight (50.000) and physico-chemical properties, it remains in the vascular system; during the first hour, the plasma level is three times higher than for Gd-DTPA. MRI was performed at 1.5 T using a SE sequence with TR/TE = 300/15 or 20 msec. Signal intensities of muscle, liver and kidney were measured before and after intravenous injection of the contrast agent (0.1 mmol/kg) during 8 hours in the rat (n = 3) and up to 2 wk in the rabbit (n = 3). A dose response study in three additional rabbits confirmed that the 0.1 mmol/kg dose was optimal. The pharmacodynamics results show that the effects of polylysine-(Gd-DTPA) are similar in both the rabbit and the rat. The liver signal is enhanced by about 60% immediately after injection in both species. This enhanced signal decays to half its maximal value in about one hour, which makes the contrast agent useful for clinical applications at a dose of 0.1 mmol/kg. In the kidney medulla and cortex the signals are enhanced by much larger factors (about 3 to 4); it takes at least one day for the kidney to clear the contrast agent in both species.
Animals↗
Localized 1H NMR spectroscopy in fifty cases of newly diagnosed intracranial tumors.
Fifty patients with newly diagnosed, untreated intracranial tumors were examined with 1H nuclear magnetic resonance single-volume spectroscopy (MRS) using a 1.5 T whole-body MR system. Prior to the MRS, contrast enhanced MR and/or CT imaging studies were carried out. Histological verification was obtained in all patients except one. All tumor spectra revealed distinct abnormalities as compared with the normal brain spectra. Although most meningiomas showed a rather characteristic spectral pattern, generally features specific for the various tumor types were not observed. For instance, though a strong lactic acid signal was seen in most malignant tumors, this signal was also evident in five benign neoplasms.
Adult↗