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Biomedical subjects

C Varotti

Publications and source records attributed to C Varotti.

At least 37 records · Page 2Linked to original sources
PubMed1992

Telogen effluvium due to recombinant interferon alpha-2b.

Five of 10 patients receiving long-term recombinant interferon alpha-2b therapy complained of considerable hair loss. The pull test and the trichogram showed a telogen count consistent with a telogen effluvium. In 2 patients the telogen count progressively improved despite continuing the treatment, whereas in 3 patients the trichogram continued to show an increased telogen count until interferon therapy was discontinued. Pohl-Pinkus hair constrictions were also present in 2 patients.

Adult↗
PubMed1992

Linear alopecia mucinosa along Blaschko lines.

We present a case of linear reversible non-inflammatory alopecia mucinosa in a 25-year-old Nigerian patient. The patient exhibited an arciform bald patch on the scalp and follicular mucinosis in both lesions. The possible relationships between the unusual linear arrangement of alopecia mucinosa along Blaschko's lines and lichen striatus are discussed.

Adult↗
PubMed1991

Xanthoma disseminatum: a case with extensive mucous membrane involvement.

A 37-year-old man had red or brownish papules on his face, chest, and groin, where they coalesced into plaques. Endoscopic examination revealed the presence of small xanthomatous papules on the mucous membrane of the stomach. A biopsy specimen revealed a dense infiltrate of histiocytes, foam cells, Touton giant cells, and inflammatory cells. The diagnosis of non-X histiocytosis was confirmed by immunohistochemical studies of the infiltrate.

Adult↗
PubMed1991

Hypertrophic lichen planus occurring after surgical procedures.

Two patients showed hypertrophic lichen planus at the sites of previous surgical procedures in their lower extremities after granulomatous reactions. Knots of implanted sutures too close to the epidermis may have caused the inflammatory reaction. Although granulomatous reactions occurring after surgical procedures are fairly common, no cases of lichenoid lesions have been reported previously.

Aged↗
PubMed1990

Melanocytes in clear cell acanthoma.

The presence of melanocytes in 11 clear cell acanthoma cases was investigated by silver impregnation. Melanocytes were always present, their density showing great variability from case to case and within each individual neoplasm. The possible existence of a pigmented counterpart to clear cell acanthoma is discussed.

Aged↗
PubMed1990

Papular and papulovesicular acrolocated eruptions and viral infections.

Twenty-six children with a symmetric papular or papulovesicular acrolocated eruption were studied to evaluate a possible link with viral infection. A history of a recent immunization was present in four patients, two of whom had a polio vaccine virus isolated from their stool samples. There was serologic evidence of a recent Epstein-Barr virus infection in one patient, adenovirus infection in another, a concurrent Epstein-Barr virus and adenovirus infection in a third, and cytomegalovirus infection in a fourth. Viral cultures were positive in two patients for adenovirus and in two others for rotavirus. Although some of the virologic findings could have been coincidental, this study confirms that multiple viral infections can be related to most papular and papulovesicular acrolocated eruptions of childhood. Virologic investigations in the earlier phases of the eruption are recommended to identify the etiologic factors of these lesions.

Adenoviridae Infections↗
PubMed1990

Massive lymphomatous nail involvement in Sézary syndrome.

The case of a 65-year-old man affected by chronic erythroderma due to Sézary syndrome and massive lymphomatous infiltration of the nails is reported. The clinical features of the nail lesions, consisting in thickening and discoloration of the nail plates, were not diagnostic. The nail biopsy showed a typical epidermotropic T cell lymphomatous involvement of all the nail constituents. Immunohistochemical characterization of the nails and skin lymphomatous infiltration showed identical results, confirming the neoplastic etiology of both the chronic erythroderma and the nail dystrophy.

Aged↗
PubMed1990

[The Lupus Band Test and serology of lupus erythematosus. Our experience].

The Authors studied, from 1986 to 1988, 84 patients (24 men and 60 women, in an age group that went from 13 to 75 years, with an average of 42 years) in whom DLE was diagnosed. In these patients, a direct immunofluorescent assay was carried out on the affected skin, on the non-affected photoexposed skin, and on the non-affected non-photoexposed skin: furthermore, the serum of these patients was tested for the presence of antinuclear antibodies (ANA), antibodies to extractable nuclear antigens (anti-ENA), and antibodies to double-stranded DNA (anti-DNA). In the study, a significant correlation between the presence of ANA and entity of cutaneous involvement at the Lupus Band Test was found. Furthermore, it was noticed that anti-ENA and/or anti-nDNA tend to be present in association to a positive Lupus Band Test in all 3 biopsied tissues.

Adolescent↗
PubMed1989

Immunological parameters in Darier's disease.

Patients with Darier's disease have frequently been observed to develop severe bacterial and viral infections. Previous studies have indicated some derangement in the immune system, even though no consistent or specific abnormality has yet been demonstrated. We performed the results of immunologic studies in 10 patients with Darier's disease. In each patient humoral immunity and cell-mediated immunity (in vivo and in vitro) were evaluated and leukocyte chemotactic function was assayed. Humoral immunity was normal; as regards clusters of differentiation (CD), a slight increase in CD4 lymphocyte subpopulations was observed in 7 patients and of CD4/CD8 ratio in 1 case. The lymphocyte responses to phytohemagglutinin and concanavalin A were normal, whereas the response to pokeweed mitogen was decreased slightly, but not significantly. Normal random and chemotactic mobility was found in all the patients except one. The data obtained do not show important immunological alterations. Our patients did not have a high propensity to develop severe infections and this may explain the absence of significant immunological derangement. Our data confirm that no immunological derangement is associated with Darier's disease.

Adult↗