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C Vecchioli Scaldazza

Publications and source records attributed to C Vecchioli Scaldazza.

At least 19 recordsLinked to original sources
PubMed2000

[Repeated bladder metastases from renal cell carcinoma. Report of a case with particular attention to the use of immunomodulators].

The case of repeated metastases of the bladder from renal cell carcinoma in a 59 year old male patient is presented. Two years after nephrectomy the ureteral stump and the bladder were interested by two different metastases. Afterwards, other nine metastases developed into the bladder during the following 12 months. Biopsy with coagulation were performed in any case. Bladder metastases ranged between 2 and 4 mm. No other metastasis was discovered by MRI and skeletal scintigraphy. Thirteen months after the first bladder metastasis, intracavitary Bacillus Calmette-Guerin was used. No report was found in the literature about BCG in the treatment of superficial bladder metastases from renal cell carcinoma. However 15 months from beginning of BCG treatment no metastasis developed from the bladder that now is disease-free after a follow-up of 19 months.

Adjuvants, Immunologic↗
PubMed1998

Metastases of the ureteral stump and bladder from renal cell carcinoma: report of a case.

The case of a 56 year-old male patient with asynchronous isolated metastases to the ureteral stump and bladder from renal cell carcinoma is presented. Ureteral metastasis was discovered 2 years after nephrectomy. Cystoscopy and MRI were performed. An excision of the ureteral stump with a cuff of bladder was carried out. No other metastasis was observed. Six months later a transurethral resection was performed on account of metastasis of the right wall of the bladder. Pathological examination demonstrated a renal cell carcinoma metastasis. After 6 months a new vesical metastasis from renal cell carcinoma was found. The small nodule of the lower part of the right wall of the bladder was removed. The literature is reviewed and the presentation, metastatic pathways, management of ureteral stump and bladder metastases from renal cell carcinoma are discussed.

Carcinoma, Renal Cell↗
PubMed1997

Rehabilitative treatment of non-neurogenic female urinary incontinence. Clinical and urodynamic evaluation.

Thirty-two female patients affected by urinary incontinence were enrolled for rehabilitative treatment (functional electro-stimulation by vaginal electrode performed three times a week for one month followed by biofeedback performed three times a week for one month). Complete clinical and urodynamic studies, urethrocystography in order to allow Blaivas and Olsson radiologic evaluation were performed. Echography of the bladder and urine cultures were done too. Patients with severe urogenital prolaxus and obesity, neurologic urinary disorders and surgery for incontinence, were excluded. The same patients were urodynamically reassessed at the end of the treatment and a detailed clinical evaluation was obtained from each patient. 78% of patients reported a considerable improvement in clinical symptoms and only 9% reported no improvement. Urodynamic findings showed an increase of maximum cystometric capacity in 6 patients, improvement of maximum urethral closure pressure and/or functional profile length in 17 patients. Disappearance or reduction of involuntary detrusor contractions were found in 2 out of 6 patients with unstable bladder.

Adult↗
PubMed1996

Oncocytic cells and parenchymal tumors of the kidney.

OBJECTIVES: The oncocytic cell is an epithelial cell with granular eosinophilic cytoplasm extremely rich in mitochondria. It may be observed in different parenchymal tumors of the kidney: oncocytoma, granular cell carcinoma (oncocytic adenocarcinoma), clear cell adenocarcinoma. Renal oncocytoma, a benign tumor, is made up exclusively of regular oncocytic cells. METHODS/RESULTS: In granular cell carcinoma (oncocytic adenocarcinoma), different aspects of malignancy are present as necrosis, cellular pleomorphism. In clear cell adenocarcinoma, on the contrary, it is possible to observe only some nests of oncocytic cells. CONCLUSIONS: The Authors underscore the presence of oncocytic cells in such different neoplasms and the possibility, especially in clear cell adenocarcinoma with nests of oncocytes, that needle biopsy or aspiration cytology from such an area can lead to a misdiagnosis.

Adenoma, Oxyphilic↗
PubMed1996

[Mitomycin-C 30 mg for 12 months versus Mitomycin-C 40 mg for 6 months in the prevention of superficial bladder carcinoma G1-G2].

A total of 60 patients with transitional cell carcinoma of the bladder G1-G2, pTa pT1 previously subjected to TUR, were randomised to receive Mitomycin-C (MMC) 30 mg for 12 months (A group) or Mitomycin-C 40 mg for 6 months (B group). The objective of this trial was to compare the prophylactic activity of MMC using two different dosages and treatments. All patients were evaluated with cystoscopy. Follow-up was of 24 months. The incidence of recurrence in the A group was 40% with a recurrence rate of 3.3. In the B group the incidence of recurrence was 27.6% with a recurrence rate of 2.2. One case of progression was present in the A group. The side effects were more frequent in the A group (37% vs 13.3%) and they were mainly due to chemocystitis. These data suggest that MMC 40 mg for 6 months appears to be superior to MMC 30 mg for 12 months in the prophylaxis of superficial bladder carcinoma.

Administration, Intravesical↗
PubMed1994

[Prognostic significance of epidermoid metaplasia in urothelial carcinoma of the bladder].

A retrospective review of 186 cases of transitional cell carcinoma of the bladder observed between 1987 and 1990 is described. Squamous metaplasia was present in 37 cases. This histological feature was especially found in association with poorly differentiated and invasive tumors: the presence of extensive areas of squamous metaplasia (metaplastic areas = or > 50% of neoplastic surface) was always found in association with high grade neoplasms. For these reasons the authors conclude that transitional cell carcinoma of the bladder showing squamous metaplasia is more aggressive than pure transitional cell carcinoma.

Carcinoma, Transitional Cell↗
PubMed1993

[Bladder instability in the elderly patient with obstructive prostatic hypertrophy: comparative urodynamic study using non-obstructed women of the same age].

62 men with prostatic hypertrophy and bladder obstruction and 31 age matched women without lower urinary tract obstruction, underwent urodynamic testing which included uroflowmetry, gas cystometry, urethral pressure measurement: electromyography and pressure flow study was only performed to the patients with prostatic hypertrophy. No patient with neurological disease, diabetes mellitus, pelvic operation, neoplasm or stone of the bladder was admitted to the study. Involuntary detrusor contractions (unstable detrusor) were found in 74.2% of male patients and in 25.8% of female patients. In male patients aged over 72 the percentage was 81.8% while in the female patients of the same age was 60%. All the 62 male patients underwent prostatectomy. Two months after surgery, acystometry was done. Unstable detrusor was found in 63.1% of cases. Patients over 80 had a percentage of 100%. These data suggest obstructive prostatic hypertrophy as an important factor in development of involuntary bladder contractions, but the primary pathophysiological factor appears to be age of patients.

Age Factors↗
PubMed1993

[Prophylaxis of transitional cell carcinoma of the bladder G1-G2; pTa-pT1 with mitomycin C or interferon alpha-2a. Preliminary data].

No. 54 patients with transitional cell carcinoma G1-2; pTa-pT1, were treated with intravesical therapy with Mitomycin C (MMC) (first group of 27 patients), and Interferon alfa 2a (IFN) (second group of 27 patients), following transurethral resection. The objective of this trial was to compare the prophylactic activity of these two drugs. All patients were evaluated with cystoscopy and urine cytology. Mean follow-up was for the first group of patients (MMC) of 10.4 months, for the second group (IFN) of 12 months. The incidence of recurrence in the first group (MMC) was 11.1% with a recurrence rate of 2.1. In the second group (IFN) the incidence of recurrence was 51.9% with a recurrence rate of 7.4. No case of progression evaluated by grade and stage was observed. The side-effects were more frequent in the MMC group and they were mainly due to chemocystitis. These data suggest that MMC appears to be superior to IFN in intravesical therapy of superficial bladder carcinoma.

Carcinoma, Transitional Cell↗
PubMed1989

[Incidental carcinoma of the prostate].

The purpose of this study has been to establish the possible presence of incidental carcinoma among men with benign prostatic hyperplasia. During the period 1983-1987, 954 patients with benign prostatic hyperplasia, have been undergone transvesical prostatectomy. Prostatic tissue has been studied with sagittal sections. Sections on the surgical specimens were taking every 0.5 Cm. In this way we have obtained from 6 to 15 sections in every prostate gland for microscopic examination. The incidence of incidental carcinoma of the prostate was found to be 5.45 per cent and it represent 24.88 per cent of all prostatic adenocarcinomas.

Aged↗
PubMed1988

Inverted papilloma of the ureter.

We report a case of inverted papilloma of the ureter. To date it is the 12th case documented. The lesion was treated by conservative surgery; negative controls following the excision for 5 years represent a further proof of the benign nature of these tumors.

Humans↗
PubMedDate not supplied

[Incidental carcinoma of the prostate. Study of 683 patients operated upon for benign prostatic hypertrophy].

During the period 1988-1990, 683 patients with diagnosis of benign prostatic hyperplasia underwent transvesical prostatectomy. The purpose of the study was to establish the possible presence of incidental carcinoma of the prostate (ICP). Prostatic tissue was studied with sections taken every 0.5 cm. The incidence of ICP was 12.00%. The mean age of patients was 73.5 years. 60.98% of tumors classified T1a, 39.02% T1b. No case of G3 tumor was observed while 92.68% of neoplasms was classified G1 and 7.32% G2. 74.95% of tumoral nests into the prostatic tissue had a breadth about one millimetre.

Aged↗
PubMedDate not supplied

[Squamous metaplasia as a prognostic factor in urothelial carcinoma of the bladder].

The Authors report a retrospective review of 224 cases of transitional cell carcinoma of the bladder observed between 1986 and 1990. Squamous metaplasia was present in 45 case. This histological feature was found especially in association with poorly differentiated and invasive tumours: the presence of extensive areas of squamous metaplasia (metaplastic areas = or greater than 50% of neoplastic surface) was always found in association with high grade neoplasms and with a disease-free period shorter than transitional cell carcinoma. The Authors conclude that squamous metaplasia in transitional cell carcinoma of the bladder is a really unfavourable prognostic factor.

Carcinoma, Transitional Cell↗
PubMedDate not supplied

[Incidence of urothelial carcinoma of the bladder in males with chronic urinary retention].

The author studied all of the 1361 male patients that had been hospitalized from December 1986 to September 1990 for chronic urinary retention to determine the incidence of urothelial tumor of the bladder. Sixty-nine (5.07%) were found to have primary urothelial carcinoma of the bladder. However, in another study group comprised of 433 males over 55 with no problems of obstruction, 0.23% had a bladder tumor. This study underscores the role of urinary stasis in the development of urothelial carcinoma of the bladder.

Chronic Disease↗
PubMedDate not supplied

[Epidermoid carcinoma of the bladder].

The Authors report their personal experience of pure squamous cell carcinoma of the bladder. Between 1984 and 1988 they have observed 389 tumors of the bladder; squamous cell carcinoma was present in fifteen cases (3.8%). Epidemiology, pathology (gross configuration of tumor, histologic grading, staging according to the criteria of the UICC of 1987), presenting symptoms, treatment and survival have been considered. The Authors underline the importance of a careful histologic examination of the vesical tumors.

Aged↗
PubMedDate not supplied

[Inverted papilloma of the bladder. Presentation of 3 cases].

The author describes three cases of inverted papilloma of the bladder. In the second case the lesion was a long pedunculated (2.5 cm) papilloma arising from prostatic urethra. Follow-up ranges from six to thirty months; no recurrence and no case of malignant degeneration was observed. Phlogosis lesions of the bladder were not seen; in one case a benign hyperplasia of the prostate was present. In all cases conservative therapy was performed.

Adult↗