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Biomedical subjects

C Velican

Publications and source records attributed to C Velican.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Study on the onset of atherosclerotic lesions in human coronary arteries.

The coronary arteries of 300 fetuses, neonates, infants and children were examined by light microscope in an effort to reconstruct the natural history of the first atherosclerotic lesions. The critical period for the passage from processes of growth and remodelling to atherosclerotic involvement appeared in this series at the age of 5 years. The incidence of the earliest lesions was distributed as follows: fibrous plaques in 2% of the subjects 6--10 years old and 4% of the subjects 11--15 years old; gelatinous plaques and fatty streaks in 6% of the subjects 11--15 years old. Indirect evidence was obtained that certain branch pads or cushions acted as precursors of the first fibrous plaques. Their conversion into atherosclerotic lesions was induced by insudation, histolysis (elastolysis, collagenolysis, ground substance depletion and degenerative cell changes), followed by nodular proliferation of smooth muscle cells and abundant neoformation of ground substance and collagen fibers. The onset of the first gelatinous plaques was also preceded by insudation and histolysis followed by swelling necrosis. The appearance of the first fatty streaks seemed to be not preceded by particular structural changes. The first fibrous plaques developed only in bifurcation and emergence areas, whereas the first gelatinous plaques and fatty streaks involved the proximal segments of the main coronary vessels.

Adolescent↗
PubMedDate not supplied

Hemodynamic stresses and atherosclerosis.

An attempt is made to summarize the recent available information on the atherogenic role of hemodynamic stresses. The paper focuses attention on the interrelations between hemodynamic stresses, on the one hand, endothelial cells, smooth muscle cells, aortic and coronary walls on the other. In addition data are presented on the atherogenic role of hemodynamic changes induced by arterial hypertension and myocardial revascularization.

Arteriosclerosis↗
PubMedDate not supplied

Particular aspects of the children coronary artery remodelling.

Coronary media shows a very reduced capacity to add after birth new rows of smooth muscle cells to the preexisting ones, in contrast to the media of other organ arteries. This medial deficiency is compensated by a rapid and diffuse intimal thickening which acts as an atherogenic factor. In addition the prevalence of longitudinally arranged smooth muscle cells in many segments of the coronary bed suggests that these segments react in a different manner to nervous stimuli, catecholamines and drugs.

Adolescent↗
PubMedDate not supplied

A light microscopic study on coronary atherosclerosis in an unselected population sample of Bucharest aged 41-50 years.

A light microscopic study was carried out in the coronary arteries of 112 apparently healthy subjects aged 41-50 years who died of accidents, in an attempt to reveal some particular aspects of atherosclerotic involvement occurring in the preclinical stage of coronary heart disease. Three of these particular aspects were stressed in the present study: 1. The important occurrence during the fifth decade of life of microthrombi and their encrustation within preexisting and newly formed atherosclerotic plaques, followed by a significant augmentation in the obstructive character of these plaques. 2. The dramatic increase in the number of subjects with a three-vessel involvement by atherosclerotic plaques. 3. The appearance of many obstructive atherosclerotic plaques in some branch vessels usually unopened and/or not removed during ordinary gross inspection.

Adult↗
PubMedDate not supplied

Age and atherosclerosis--related changes occurring in the "intercalated vascular segments" of human coronary arteries.

The term "intercalated vascular segment" is used by the authors to designate a structural accomodation to the existence of diffuse thickened intimas, occurring as local vascular connections between the lumen of the main coronary arteries and the branch mouths of the daughter vessels. They exhibit the light microscopic feature of cylindrical conduits including only an endothelial sheet encased by the intimal connective tissue. The most important change related to aging and atherosclerotic involvement seems to be the conversion of some intercalated vascular segments in rigid, undistensible and narrowed conduits; this might produce local changes similar to those of a fixed stenosis. In the material examined the presence of narrowed conduits was sometimes associated with the existence of small areas of necrosis in the myocardium supplied by the vessel corresponding to the respective intercalated vascular segment.

Adolescent↗
PubMedDate not supplied

A method for the study of the dynamics of atherosclerotic involvement of human coronary arteries.

A method able to reveal the progression of atherosclerosis from children to mature adults is proposed, based on the successive light microscopic examination of similar selected topographic sites of the coronary arterial tree placed in sequence according to age, sex and branching anatomical pattern. The dynamic reconstruction of thousands of static views revealed a linear and parallel increase in the number of all types of early atherosclerotic lesions: fibromuscular plaques, intimal necrotic areas, incorporated microthrombi and fatty streaks. Some endogenous and exogeneous risk factors for coronary heart disease accelerated this age-related rate of progression and also gave rise to particular cycles of evolution toward lesions of possible clinical significance.

Adolescent↗