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C Vigneron

Publications and source records attributed to C Vigneron.

At least 127 records · Page 7Linked to original sources
PubMed1979

Comparison of in vitro effects of normal IgG and of a monoclonal IgG on the rheological behaviour of erythrocytes.

Erythrocyte sedimentation, viscosity, electrophroetic mobility, and osmotic fragility were measured in a study of the rheological behaviour of the erythrocyte in vitro. In comparison with physiological saline solution, a suspending medium containing a gamma2lambda2 monoclonal IgG from a patient with multiple myeloma caused rheological changes 2-3 times as great as a medium with normal IgG. Our results demonstrate the existence of nonimmunological interactions between erythrocytes and normal or monoclonal immunoglobulins, and they raise questions about the widely held assumption that paraproteins are structurally 'normal'.

Blood Viscosity↗
PubMed1979

[Monoclonal immunoglobulins and serum viscosity: contribution of the idea of activation energy to the paraprotein concept (author's transl)].

The simultaneous study of dynamic and cinematic viscosity in 34 control sera and 49 paraprotein sera showed that there was a simple relationship between the viscosity and the total serum protein content both in normal sera and in paraprotein sera. When the ratio of monoclonal immunoglobulins/total proteins is less than 55%, the viscosity is little or not modified in the case of the IgGk paraproteins studied, whereas it was increased in the case of IgA, IgM and IgG LAMBDA SERA. Beyond 2 cSt, it is not however possible to incriminate a particular type of heavy chain nor even a light chain. The measurement of the viscosity in relation to the temperature permitted us to show that the IgA, IgG, and IgM sera studied all presented an activation energy of outflow (E in Kcal) higher than that of normal sera and the highest rise is due to IgA paraproteins. The concept of energy activation permits us to say that paraproteins have a different behaviour from normal proteins, probably due to disorders in their structural arrangement.

Blood Viscosity↗
PubMed1979

[In vitro influence of albumin, gammaglobulin and fibrinogen on the sedimentation rate and the rheological behaviour of the red cell (author's transl)].

The complexity of the mechanisms which enter into play in the phenomenon of erythrocyte sedimentation have for long aroused the curiosity of research workers. A simultaneous study of this parameter and of the viscosity, of the relative zeta potential together with the osmotic fragility, led us to appreciate the respective actions of three isolated plasma proteins : albumin, immunoglobuin G, fibrinogen, on the ESR and on the rheological properties of the red cell.

Albumins↗
PubMed1978

Mechanisms of erythrocyte sedimentation.

Concomitant mechanisms of red-cell sedimentation are discussed: 1. physical 2. biological (the effects of plasma proteins, viscosity, and the number and size of erythrocytes on the rate of sedimentation). 3. an up-to-date review of the principal methods and systems used to measure the sedimentation rate--Automation of the Westergren initial methodology.

Biophysical Phenomena↗
PubMed1978

Prenatal diagnosis of galactosemia.

We have monitored 3 pregnancies at risk for galactosemia by deficiency in Galactose-1-Phospho uridyl transferase. Galactosemia was diagnosed in the 1st case; heterozygoty in the 2nd, and a "double heterozygoty" in the 3rd. The latter is the first example of such a diagnosis. Post natal confirmation was obtained in the three cases. Arguments are given for the usefulness of this prenatal diagnosis.

Amniocentesis↗
PubMed1975

[Study of the osmotic behaviour of human platelets].

Observation of the behaviour of platelets in hypotonic media affords an approach to the evaluation of their fragility. It should be possible to apply such a test to various fields such as the study of rheological properties of platelets, the investigation of certain pathological cases and eventual alterations during storage. The curve obtained reflects a continuous distribution of platelet osmotic fragility.

Blood Platelets↗