The authors report a case of oral submucous fibrosis and present a review of the literature available on this subject. Oral submucous fibrosis is rare outside South-East Asia where it affects from 0.2 to 1 p. 100 of the population. A few cases have been described among Europeans. The disease seems to be specific to the oral and upper respiratory mucosae. It is characterized by the progressive development of subepithelial fibrosis and the subsequent occurrence of leukoplakia which may undergo transformation into epidermoid carcinoma. It initially presents as a non-specific stomatitis, sometimes with vesicles and ulcerations. Very gradually thereafter the buccal mucosa becomes pale in parts, as well as thicker and fibrous, while leukoplakia develops. These lesions progress slowly and may eventually result in complete and irreducible trismus. Histologically, oral submucous fibrosis is characterized by chronic subepithelial inflammatory reaction followed by hyalinization. Subsequently, the fibrosis extends to the underlying muscles. The epithelium is diversely affected: atrophy is thought to be the first lesion to appear; secondarily, and under the influence of various irritant factors, epithelial hyperplasia, ortho- or parakeratosis of the stratum corneum, or even cellular abnormalities may develop.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1985

[Malignant eccrine poromas. Ultrastructural study of 2 cases].

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Adenoma, Sweat Gland↗

PubMed1985

[Linear IgA bullous dermatosis in adults].

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Adult↗

PubMed1984

[Cutaneous manifestations of cytomegalovirus infections].

The cutaneous manifestations that occur commonly in cytomegalovirus (CMV) infections are erythematous maculopapular eruptions or purpuric rashes . But, CMV has been detected in chronic mucosal and skin ulcerations, benign tumour-like lesions and eroded gingivitis. Most of these cutaneous lesions are secondary to vasculitis of the small dermal, subcutaneous tissue or submucosa vessels. The authors discuss the different physiopathological mechanisms which may be involved in the development of these viral-induced vasculitis. Dermal erythropoiesis in neonatal infants and localized granulomatous lesions have been also reported.

Adult↗

PubMed1984

[Non-drug toxicoderma by a respiratory or probable percutaneous route (fluorocarbons, butane, phenyl-azo-beta-naphthol)].

Four cases of cutaneous rash, clinically more or less similar to erythema multiforme have been observed in patient who either stayed in a room with an accidentally high content of fluorocarbons, or had a skin contact with butane or phenyl-azo-beta-naphthol. The cutaneous lesions appear to be secondary to absorption of the toxic product, and probably induced by inhalation rather than by percutaneous penetration. Arguments for the responsibility of the substances rely on anamnestic data.

Adult↗

PubMed1983