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Biomedical subjects

C Vineis

Publications and source records attributed to C Vineis.

16 recordsLinked to original sources
PubMed2006

[Recurrent intraparenchimal haemorrhages in a patient with cerebral amyloidotic angiopathy: description of one autopsy case].

Cerebral amyloidotic angiopathy represents the most frequent cause of lobar haematoma in young patients and represents 5-10% of the non-traumatic cerebral haemorrhages. In the present work, we describe one autoptic case of recurrent cerebral haemorrhages in a 58-year-old woman. Macroscopically in the brain multiple haemorragic areas were present in the right frontal pole, right frontal and temporo-parietal lobes with homolateral ventricular inundation. The histological, histochemical, immunohistochemical, ultrastructural and biomolecular investigations confirmed the presence of amyloid deposits in the middle-size and little-size cerebral arteries. We report, moreover, a novel mutation (Leu705Val) within the Abeta sequence of a AbetaPP in a family with autosomal dominant, recurrent intracerebral hemorrhages beginning in the sixth decade of life.

Aged↗
PubMed2005

[The use of a computerised system in the reading of cytological cervicovaginals smears during programming of regional screening (one year of experience using the autopap system)].

From january to december 2001 n. 23.940 conventional Pap smears were consecuetively processed by the Autopap System. All these slides classified by AutoPap as "review" were subjected to a conventional reading by cytotechnologist using FOV areas selected by AUTOPAP and classified according to the BETHESDA System. All smears with high grade lesions were submitted to surgical biopsy and histologic diagnoses. 10%of those slides which were classified as No Further Review underwent a rescreening. Objective of our study was assess if a computerised reading of conventional cervicovaginal smears could really help manual screening, and to verify if the rank in "quintiles" given by the system to identify the lesions, correlates to the grade of morphological atypia found during manual revision. The accuracy of the results selected in the FOV areas for the manual guided revision was high. The AUTOPAP System selected as No Further Review mostly slides within normal limits, and no severe abnormalities (HSIL) were categorised by device as No Further Review. We also noted an effective reduction in the reading time: (6 minutes per smears by using the AUTOPAP compared to the 10 minutes per smears during manual conventional reading). If this date is summed up to 22% of all the smears classified as "No Further Review" (therefore it is not necessary to undergo a revision) a real redecution of the work load could be obtained.

Diagnosis, Computer-Assisted↗
PubMed2003

[Benchmarking in pathological anatomy].

Data from five different Institution of Pathological Anatomy Hospital Services are presented in order to show one (the benchmark) of the multiple existing ways to approach the budget problem and the macroeconomic management of our Services. The aim of this work is not to show the "best" way to work in terms of cost-efficacy but only a methods to compare our results with others. Nevertheless from this study is possible also to make some considerations about medical and technical workload in different services with different habits.

Autopsy↗
PubMed2002

[Comparative analysis of various biochemical and immunohistochemical methods for evaluating hormone receptors in breast carcinoma].

The aim of this study was to compare the grade of concordance between three methods to evaluate and to quantify the expression of estrogen and progesterone receptors in 180 cases of breast cancer. The methods compared were dextran-coated charcoal (DCC) method, immunochemical analysis (ICA), and immunohistochemistry (IHC). The grades of concordance are so summarized: (1) 77.8% for estrogen receptors (ER) and progesterone receptors (PgR) with DCC and ICA methods (r = 0.53 and r = 0.64, respectively); (2) 83.3% for ER (r = 0.53) and 75.6% for PgR (r = 0.64) with DCC and IHC methods; (3) 87.8% for ER (r = 0.98) and 86.7% for PgR (r = 0.99) with ICA and IHC methods. Nowadays, the technique carried out on tissue sections provides the most reliable information. The IHC method performed on formalin-fixed and paraffin-embedded tissue is preferred in laboratories with a high work load because it is easy and inexpensive and can be automated.

Adsorption↗
PubMed1996

[What posttreatment monitoring in Whipple's disease? A case report].

The authors--which publish an overview about Whipple's disease in this issue, pages 609-611--report the case of a 67-year-old man admitted to the hospital because of migratory arthralgia, low-grade fever, lymphadenopathy, diarrhea, and impaired intestinal absorption. The microscopical examination of the intestinal mucosa showed an infiltration of the lamina propria by foamy PAS-positive macrophages. The patient was treated with antibiotics for 1 year and obtained clinical remission. The authors discuss if it is opportune, in subjects with this disease, to repeat the small-bowel biopsies at the end of the antibiotic treatment in absence of clinical manifestations of relapse or not.

Aged↗
PubMed1993

[Sudden death during a game of soccer in a young adolescent with a myocardial muscle bridge].

The case of a young adolescent who suffered a sudden death while playing soccer is described. At necropsy a long intramyocardial segment of the obtuse marginal branch of the left coronary artery was found, with fresh ischemic damage in the surrounding myocardium. We comment about negativity of the tests the boy had undertaken because of a single syncopal episode he suffered in similar circumstances. Those tests included two 24-hour Holter monitorings, a maximal electrocardiographic stress-test and an electrophysiologic study. In no occasion did he complain of angina pectoris.

Adolescent↗
PubMed1985

Hodgkin's disease developing in a patient with angioimmunoblastic lymphadenopathy with dysproteinemia--a case report.

The case of a woman presenting the clinical and pathologic phenomena of angioimmunoblastic lymphadenopathy (AILD) with dysproteinemia is reported. The patient developed lesions in the lymph nodes, skin, lungs, liver and spleen, and her response to steroid and cyclophosphamide therapy was poor. At autopsy, microscopic findings in the mediastinal and abdominal lymph nodes were consistent with the diagnosis of Hodgkin's disease. Whereas the development of immunoblastic lymphoma is frequent in AILD, Hodgkin's disease is far less common. It is argued that malignant lymphoma in AILD may be the consequence of chronically depressed lymphocyte functions.

Adult↗
PubMed1984

[Lymphangioma of the spleen. Apropos of 2 cases].

On the basis of two observed cases and a review of the literature, the extreme rarity of cystic lymphangioma of the spleen is pointed out. The presumed pathogenesis of the condition is described as are its greater frequency among the young, the possibility of dangerous complications and its non-malignity. The superiority of non-invasive instrumental diagnosis (echotomography and CAT) over traditional techniques is reported. Finally splenectomy is identified as the therapy of choice.

Adolescent↗
PubMedDate not supplied

[Bladder hemangioma. Presentation of a case and review of the literature].

The Authors report a case of hemangioma of the bladder, probable relapse of a similar neoplasia treated with endoscopic diathermy 28 years before, in a 34 year old patient. The clinical presentation, the localization, the subject's age, the therapy and the lesion's histological type recall the main features of this neoplasia. Contrary to all traditional concepts, the diagnosis was made after a biopsy, with no particular problems occurring during the examination. The localization in the bladder dome allowed a good surgical exeresis in a healthy tissue causing a further relapse to be unlikely despite the muscular invasion of the neoplasia.

Adult↗
PubMedDate not supplied

Cytologic diagnosis of primary pulmonary actinomycosis: report of two cases.

Two cases of primary pulmonary actinomycosis had a radiologic and clinical picture of malignancy. The cases were diagnosed by microscopic examination of sputum that had been embedded in paraffin. The sputum samples were sent to the cytology laboratory for screening for neoplastic cells, and colonies of Actinomyces were seen in all samples. The authors emphasize the difficulties that can be encountered by the cytopathologist in identifying classic actinomycotic colonies in debris.

Actinomyces↗
PubMedDate not supplied

[Cytospectrophotometry in the grading of malignant breast tumors].

The nuclear DNA content of neoplastic cell was measured in 30 cases of carcinomas of the human breast. The normal lymphocyte was used as a reference for the DNA value corresponding to a diploid number of chromosomes. Samples from the same cases were embedded in paraffin and stained with haematoxylin and eosin. The nuclear DNA content is compared with the histological malignancy grading following Bloom and Richardson.

Breast Neoplasms↗