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Biomedical subjects

C Vlădescu

Publications and source records attributed to C Vlădescu.

At least 19 recordsLinked to original sources
PubMed1975

Plasma corticosterone secretion in rats after irradiation.

In this material it was confirmed that the irradiated rats present a two-phase corticosterone hypersecretion. The responses are greater to higher doses of irradiation (700 R as compared with 500 R). The postirradiation hyperglycemia is not correlated with the corticosterone hypersecretion, having its peak value a day before.

Adrenal Cortex↗
PubMed1975

Researches regarding the effect of total x-ray irradiation on the collagen metabolism in rats.

1. Hydroxyproline is an amino acid specific of collagen, so that any changes in its urinary concentration is a proof of the metabolical changes of collagen. 2. The basic value of hydroxyproline in rats investigated by us was of 270 +/- 49 mug/24 hours. 3. The total irradiation with 700 r induced a marked increase of urinary hydroxyproline, beginning after 24 hours and with a maximum level after 48 hours.

Animals↗
PubMed1975

Effects of mild hypoxia (2200 m) on catecholamine and corticosterone secretion.

In experiments carried out in male Wistar rats submitted in laboratory to a 2200-m depressurization the urinary noradrenaline and adrenaline elimination, as well as the plasma corticosterone level were investigated. In rats previously submitted 12 days only to the environmental stress the true depressurization (7 days) produced a relatively increased noradrenaline and adrenaline elimination. A similar increased catecholamine output was observed in rats submitted directly to hypoxia. The plasma corticosterone level was unmodified by hypoxia of the same value.

Adrenal Glands↗
PubMed1975

Study on free and total urinary hydroxyproline in old men.

The present study deals with urinary free and total hydroxyproline (HOP) in a group of adults between 63-93 years old, admitted in a sanatorium for geriatries. The average value of the free HOP on the whole group was of 1.28 mg/24 hours (0.52-2.10) and that of the total HOP was of 16.54 mg/24 hours (10.7-27.94). The free HOP does not show differences as compared to the adults; but the total one decreases in old people. The data obtained are discussed and compared with the literature.

Age Factors↗
PubMed1975

The effect of ionizing irradiation on the collagen general metabolism in normal and adrenalectomized rats.

The effect of doses of 100, 250, 500, and 700 R on the urinary excretion of hydroxyproline in normal and adrenalectomized rats was followed over a period of 30 days. Urinary hydroxyproline is decreased by 100 and 250 R doses and increased by those of a 500 and 700 R. The first effect is explained by an increase of the insolubility of collagen as a result of the appearance of additional intermolecular crosslinkages, and the second one by breakage of the mentioned linkages. Adrenalectomized rats, both normal and irradiated, show a more significant decrease in the urinary excretion of hydroxyproline. Results are discussed on the basis of related bibliography, outlining the practical utility of the research.

Adrenal Glands↗