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Biomedical subjects

C Vogtmann

Publications and source records attributed to C Vogtmann.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Effect of pregnancy and perinatal parameters--including mode of delivery--on survival rate of "low birth weight premature infants" (less than 1,500 g)].

A retrospective analysis of 225 very low birth weight infants (less than 1500 g) was made, to assess the influence of the mode of delivery on the survival rate. In 186 preterm deliveries which could not be prevented by therapeutic measures, we included additionally certain gestational and perinatological parameters. Generally, an average survival rate of 72% was found in this study. In addition to the well-known negative influence of birth weight less than 1000 g and gestational age of less than 28 weeks, such parameters as antenatal pre-pathological CTG findings, haemorrhages at the time of hospitalisation, and ineffectuousness of tocolytic drugs, were associated with a reduced survival rate. In contrast, the presence of anamnestic risk factors of preterm delivery and prolongation of gestation by one day and more improved the survival rate. Additional consideration of foetal presentation showed, that abdominal delivery was fundamentally safer in cases with breech and transverse presentation. Whether a higher survival rate can be achieved by vaginal delivery in cases of breech presentation with premature rupture of membranes or a gestational age greater or equal to 28 weeks, remains to be proved. A gestational age of less than 28 weeks or antenatal prepathological cardiotocographic findings will facilitate in future the decision to perform Cesarean section in cases of inevitable premature deliveries with cephalic presentation.

Cesarean Section↗
PubMed1991

[15 years Perinatal Center of the Leipzig University].

Report about experiences with developing a perinatal center step by step an the University of Leipzig, primarily directed to improve the results of premature labour, then expanded by intensive diagnostics and treatment and uniform documentation of all risk pregnancies. Perinatal and neonatal mortality decreases following this management.

Female↗
PubMed1988

[Effects of early therapy with indomethacin on the manifestation of a persistent ductus arteriosus in extremely underweight premature infants].

In a randomized study the effect of an early prophylactic indomethacin treatment on the incidence of the patent ductus arteriosus (PDA) in very low birth weight infants (VLBWI) and their postnatal course were investigated. 19 VLBWI (weight 1221 +/- 158 g, gestational age 28.2 +/- 1.3 weeks) received 0.2 mg/kg indomethacin 3 times p.o. in 12 h intervals beginning on the 3rd day of life. 22 VLBWI with comparable weight (1250 +/- 154 g, gestational age 28.4 +/- 1 weeks), mode of delivery and postnatal adaptation served as controls. PDA was diagnosed clinically and by a decreased ratio of the systolic time intervals preejection period (PEP)/left ventricular ejection time (LVET) less than 0.3. PDA were seen in 7 indomethacin treated VLBWI and in 13 newborns of the control group. A symptomatic PDA developed in 4 infants of the latter group only. The indomethacin group was characterized by an increased ratio PEP/LVET from day 3 to 5 as an evidence for a diminished ductal shunt. Their weight loss was 3% lower and they regained their birth weight 5 days earlier. Otherwise, there were no differences in mortality and morbidity. Despite the proven efficacy of an early indomethacin treatment its use is recommended only for infants with a high risk for a PDA substantiated by a low ratio PEP/LVET less than or equal to 0.24 at the 3rd day of life.

Birth Weight↗
PubMed1987

[Recommendations for the diagnosis and therapy of bacterial infections in premature and newborn infants].

In a survey the authors present the most important facts of diagnostic and therapy of bacterial infections in term and preterm neonates. It is a synthesis of an extensive study of the literature and of own experiences. Besides microbiological diagnostic and antibacterial chemotherapy one can find also suggestions concerning hematological and chemical diagnostic methods as well as of parenteral and oral nutrition and immunotherapy.

Anti-Bacterial Agents↗
PubMed1987

[B streptococcal infections in the neonatal period and infancy].

From January 1975 to March 1985 37 newborns and infants with B streptococcal infections were treated in the Pediatric Hospital of the Karl Marx University in Leipzig. The percentage of B streptococcal infections of all neonatal bacterial infections rose in this time from 6.9% to 15.7%. There were 23 early onset type infections and 14 late infections; 12 of the 37 infants died. Septicemia and meningitis were the most important clinical features. The time of beginning of the clinical symptoms in the postnatal period and the results of serotyping suggest a connatal infection in most cases.

Anti-Bacterial Agents↗
PubMed1983

Red cell creatine in term and preterm, adequate and small for gestational age newborns after normal pregnancy or risk conditions. I. Statistical analysis of creatine in various groups of newborns.

The red cell creatine concentration was determined in 174 newborns (cord blood) and in 50 healthy adults. Normal values for term adequate for gestational age newborns without intrauterine and perinatal risk (n = 53) were established to lie significantly above those for adults. Newborns after risk pregnancies had higher mean creatine concentrations than those born after uneventful gestation. Small for gestational age (SGA) infants proved to have the lowest creatine concentration of all newborn groups. The creatine values of our SGA children suggested that not more than 20% of them had chronic intrauterine hypoxia. It is concluded that red cell creatine at birth may serve to characterize in retrospect erythropoietic dynamics in cases of intrauterine growth retardation and intrauterine risk.

Creatine↗
PubMed1983

Red cell creatine in term and preterm, adequate and small for gestational age newborns after normal pregnancy or risk conditions. II. Mathematical analysis of 12 risk conditions in relation to the creatine level at birth.

Univariate and multivariate analysis of variance and discriminant analysis were performed on newborns with respect to the level of red cell creatine at birth (cord blood) and 12 risk conditions occurring during the last trimester of gestation and birth. 111 of the 174 newborns studied had been at risk. The factor "small for gestational age" (SGA) showed to have a negative coefficient of discriminant function, i.e. it contributes to lower creatine values at birth. Other risks are shown to raise the creatine level. For "adequate for gestational age" (AGA) newborns "Rh-incompatibility", "toxoplasmosis", "premature and/or prolonged rupture of the membranes", "complications of the umbilical cord" and - to a minor degree - "pyelonephritis of the mother", "threatened premature labour", and "toxemia of pregnancy" were shown to be significant risks leading towards high red cell creatine concentrations in cord blood. For the SGA infants "preterm birth", "threatened premature labour", "green amniotic fluid" and "toxemia of pregnancy" were the most important risks relating to high creatine levels of red cells at birth.

Analysis of Variance↗