PubMed Health⌕ Search

Biomedical subjects

C W Blichmann

Publications and source records attributed to C W Blichmann.

8 recordsLinked to original sources
PubMed1998

Bullous erythema multiforme following herpes zoster and varicella-zoster virus infection.

Four cases of herpes zoster-induced bullous erythema multiforme (EM) are reported. Three patients presented with widespread skin lesions 10 to 14 days after an episode of thoracic herpes zoster. In these patients a high increase in varicella-zoster virus (VZV) antibody titer was detected, indicating secondary VZV infection. Histologic examinations of skin biopsy from a patient with widespread lesions (case 4) revealed a mixture of EM, toxic epidermal necrolysis and herpetic virus infection. VZV should be included in the list of infectious agents able to trigger EM and Stevens-Johnson syndrome.

Acyclovir↗
PubMed1989

Effects of single application of a moisturizer: evaporation of emulsion water, skin surface temperature, electrical conductance, electrical capacitance, and skin surface (emulsion) lipids.

Effects of single application of an oil in water emulsion were studied on the forearm skin of 12 healthy volunteers. Five different non-invasive methods were used. Values were followed for 360 min after application of the emulsion, with the contralateral forearm as untreated control. The evaporation of emulsion water from the skin surface immediately rose to high values, but within 15 min returned to the original level. A parallel initial increase in conductance was observed; however, this was followed by a slightly increased level throughout the 360 min study. Electrical capacitance was also slightly increased throughout the study. Skin surface lipids, dominated by emulsion lipids, were increased, with high values for at least 120 min, followed by a gradual decline toward normal. Single application of emulsion is characterized by an initial evaporation phase, with evaporation of emulsion water, which lasts less than 15 min, followed by a lipidization phase, which lasts at least 360 min, dominated by the oil-constituent of the emulsion undergoing epidermal absorption. During the lipidization phase, epidermal hydration parameters are slightly but consistently improved.

Aged↗
PubMed1989

Effects of repeated application of a moisturizer.

Epidermal hydration following repeated application of an oil in water emulsion was studied on the forearm skin of 16 healthy females by non-invasive methods. The lotion was applied twice daily for 7 days, and values were followed 7 days after cessation of treatment. The opposite forearm served as an untreated control. Electrical conductance and capacitance showed similar results, i.e. increased values (p less than 0.001) after 2 days of application, reaching a plateau during further applications. Two days after cessation, values were still increased (p less than 0.001), and the conductance was also increased 7 days after cessation of treatment. The water evaporation and the cutaneous blood flow did not change, i.e. indicating no mild irritant effect. Skin surface lipids did not change, i.e. indicating that no significant amounts of emulsion oil remained on the skin at the time of recording. Probably components of the oil phase of the emulsion are absorbed into the epidermis, which is associated with improved hydration as a later event.

Adult↗
PubMed1988

Assessment of skin moisture. Measurement of electrical conductance, capacitance and transepidermal water loss.

Experiments on skin moisture, i.e. the hydration state of the outer epidermis, were undertaken using three different types of equipment, i.e. the Skicon-100 and Corneometer CM 420 hydrometers and the Servo Med EPI evaporimeter. The studies included 10 healthy volunteers. Water was applied to test sites on the forearm and the palm of the hand, and effects monitored by the three methods. Parallel increases in conductance, capacitance and transepidermal water loss were registered for a duration of about 5 min. The Skicon-100 was more sensitive for measurement of increased hydration, while the Corneometer CM 420 might be more sensitive for measurement of decreased hydration. Inter- and intra-individual variations were minor with all instruments. According to reproducibility studies, the Corneometer CM 420 was more accurate than the Skicon-100. Technical experiments indicated that the Corneometer CM 420 depicts changes of hydration down to a depth of 0.1 mm, while the Skicon-100 measures very superficially. In conclusion, both hydrometers were deemed relevant and valid for assessment of skin moisture. The methods are complementary, and their combined use is recommended.

Adult↗
PubMed1987

Reproducibility and variability of transepidermal water loss measurement. Studies on the Servo Med Evaporimeter.

Recording technique and accuracy of the Servo Med EP1 evaporimeter were studied. The technical accuracy of this equipment was found high with a coefficient of variation of 3.3%. Measurements of transepidermal water loss (TEWL) were performed on the palm of the hand and on the flexor side of the forearm in 10 healthy volunteers. Continuous registrations were undertaken for a three-minute period and repeated immediately thereafter. Values reached a linear state 30 sec after application of the probe. The variation of TEWL in relation to time was determined in the same individuals. Measurements were repeated after 1 hour and 24 hours. In conclusion, though the TEWL as measured by the Servo Med evaporimeter shows a considerable interindividual variation, the intraindividual variation and the variation by time are relatively minor. We recommend that more detailed studies are based on paired observations, with recordings read 30 sec after application of the probe onto the skin.

Adult↗