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Biomedical subjects

C W Britt

Publications and source records attributed to C W Britt.

7 recordsLinked to original sources

Nontraumatic "spindle coma": clinical, EEG, and prognostic features.

"Spindle coma" denotes the association of alteration of consciousness with electroencephalographic (EEG) activity resembling slow-wave sleep. Clinical, EEG, and pathologic data were reviewed for 36 patients with this syndrome, who were divided into two groups, based on the level of consciousness at the time of the initial neurologic evaluation. Fifteen patients were stuporous or semicomatose; none exhibited abnormalities of brainstem motor function, and 14 survived. Twenty-one patients were comatose; 20 had abnormalities of brainstem motor function, and only 4 survived. The outcome of nontraumatic spindle coma is unfavorable when the patient is fully comatose and brainstem motor function is impaired.

Adolescent↗

Rhabdomyolysis during treatment with epsilon-aminocaproic acid.

Severe rhabdomyolysis and acute renal failure occurred in a patient receiving epsilon-aminocaproic acid. The lack of evidence of vascular involvement in the muscle biopsy specimen suggests that epsilon-aminocaproic acid may have direct myotoxicity. This drug may produce a spectrum of muscle disease from mild myopathy to life-threatening rhabdomyolysis.

Adult↗