Childhood leukemia: implications of EEG findings at time of diagnosis.
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Biomedical subjects
Publications and source records attributed to C W Britt.
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"Spindle coma" denotes the association of alteration of consciousness with electroencephalographic (EEG) activity resembling slow-wave sleep. Clinical, EEG, and pathologic data were reviewed for 36 patients with this syndrome, who were divided into two groups, based on the level of consciousness at the time of the initial neurologic evaluation. Fifteen patients were stuporous or semicomatose; none exhibited abnormalities of brainstem motor function, and 14 survived. Twenty-one patients were comatose; 20 had abnormalities of brainstem motor function, and only 4 survived. The outcome of nontraumatic spindle coma is unfavorable when the patient is fully comatose and brainstem motor function is impaired.
Severe rhabdomyolysis and acute renal failure occurred in a patient receiving epsilon-aminocaproic acid. The lack of evidence of vascular involvement in the muscle biopsy specimen suggests that epsilon-aminocaproic acid may have direct myotoxicity. This drug may produce a spectrum of muscle disease from mild myopathy to life-threatening rhabdomyolysis.
A case of spindle coma following head injury is reported in which a primary hemorrhagic rostral midbrain lesion was demonstrated by computerized tomography.
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